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Mnat1 menage a trois 1 [ Mus musculus (house mouse) ]

Gene ID: 17420, updated on 11-Apr-2024

Summary

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Official Symbol
Mnat1provided by MGI
Official Full Name
menage a trois 1provided by MGI
Primary source
MGI:MGI:106207
See related
Ensembl:ENSMUSG00000021103 AllianceGenome:MGI:106207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P36; MAT1; E130115E11Rik
Summary
Predicted to enable protein N-terminus binding activity. Acts upstream of or within several processes, including adult heart development; response to calcium ion; and ventricular system development. Predicted to be located in nucleoplasm. Predicted to be part of nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system gland. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.1), limb E14.5 (RPKM 4.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Mnat1 in Genome Data Viewer
Location:
12 C3; 12 30.37 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (73158957..73320762)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (73112185..73273988)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene sine oculis-related homeobox 6 Neighboring gene STARR-seq mESC enhancer starr_32458 Neighboring gene microRNA 9718 Neighboring gene STARR-seq mESC enhancer starr_32461 Neighboring gene sine oculis-related homeobox 1 Neighboring gene STARR-seq mESC enhancer starr_32463 Neighboring gene sine oculis-related homeobox 4 Neighboring gene predicted gene, 23910 Neighboring gene STARR-positive B cell enhancer ABC_E4028 Neighboring gene STARR-positive B cell enhancer ABC_E7146 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9148 Neighboring gene STARR-seq mESC enhancer starr_32467 Neighboring gene TRM5 tRNA methyltransferase 5 Neighboring gene solute carrier family 38, member 6 Neighboring gene STARR-seq mESC enhancer starr_32469 Neighboring gene RIKEN cDNA D830013O20 gene Neighboring gene predicted gene, 40442

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover. Helenius K, et al. Nucleic Acids Res, 2011 Jul. PMID 21385826, Free PMC Article
  2. Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1. Rossi DJ, et al. EMBO J, 2001 Jun 1. PMID 11387217, Free PMC Article
  3. Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Fisher RP, et al. Cell, 1995 Oct 6. PMID 7553872
  4. Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells provides evidence that Mat1 is not required for general transcription. Korsisaari N, et al. J Cell Sci, 2002 Nov 15. PMID 12376559
  5. Solution structure of the N-terminal domain of the human TFIIH MAT1 subunit: new insights into the RING finger family. Gervais V, et al. J Biol Chem, 2001 Mar 9. PMID 11056162

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAT1 serves as a promoter in the lung metastasis of osteosarcoma through increasing AKT1 expression.
    Title: MAT1 facilitates the lung metastasis of osteosarcoma through upregulation of AKT1 expression.
  2. Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.
    Title: Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover.
  3. investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
    Title: Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos.
  4. study found that Mat1 and Cdk7 levels are undetectable in adipose tissues in vivo and downregulated during adipogenesis
    Title: Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation.
  5. This study demonstrates a requirement for MAT1 in the operation of PGC-1 coactivators that control cell metabolism.
    Title: Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adult heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to calcium ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CAK-ERCC2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin-dependent protein kinase activating kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH core complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIK complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CDK-activating kinase assembly factor MAT1
Names
CDK7/cyclin-H assembly factor
RING finger protein MAT1
p35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008612.2 → NP_032638.2  CDK-activating kinase assembly factor MAT1

    See identical proteins and their annotated locations for NP_032638.2

    Status: VALIDATED

    Source sequence(s)
    AK155859, AK157721
    Consensus CDS
    CCDS49087.1
    UniProtKB/Swiss-Prot
    P51949, Q14BS9, Q3TZP0, Q9D8A0, Q9D8D2
    Related
    ENSMUSP00000021523.7, ENSMUST00000021523.7
    Conserved Domains (2) summary
    TIGR00570
    Location:1 → 308
    cdk7; CDK-activating kinase assembly factor MAT1
    cl17238
    Location:3 → 50
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    73158957..73320762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244008.4 → XP_011242310.1  CDK-activating kinase assembly factor MAT1 isoform X1

    See identical proteins and their annotated locations for XP_011242310.1

    Conserved Domains (1) summary
    TIGR00570
    Location:1 → 187
    cdk7; CDK-activating kinase assembly factor MAT1

  2. XM_006515526.4 → XP_006515589.1  CDK-activating kinase assembly factor MAT1 isoform X1

    See identical proteins and their annotated locations for XP_006515589.1

    Conserved Domains (1) summary
    TIGR00570
    Location:1 → 187
    cdk7; CDK-activating kinase assembly factor MAT1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51949.2 GenPept UniProtKB/Swiss-Prot:P51949

Gene LinkOut

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