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DLG2 discs large MAGUK scaffold protein 2 [ Homo sapiens (human) ]

Gene ID: 1740, updated on 11-Apr-2024

Summary

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Official Symbol
DLG2provided by HGNC
Official Full Name
discs large MAGUK scaffold protein 2provided by HGNC
Primary source
HGNC:HGNC:2901
See related
Ensembl:ENSG00000150672 MIM:603583; AllianceGenome:HGNC:2901
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSD93; PSD-93; PPP1R58; chapsyn-110
Summary
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
Expression
Biased expression in brain (RPKM 9.7), adrenal (RPKM 2.3) and 5 other tissues See more
Orthologs
mouse all
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Genomic context

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See DLG2 in Genome Data Viewer
Location:
11q14.1
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (83455012..85628373, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (83391509..85565050, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (83166055..85339417, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369420 Neighboring gene CCDC90B antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:83036792-83037292 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:83149453-83149953 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:83152064-83152757 Neighboring gene CYCS pseudogene 28 Neighboring gene uncharacterized LOC107984425 Neighboring gene DLG2 intron CAGE-defined low expression enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:83298443-83299026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:83299027-83299610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5354 Neighboring gene DLG2 antisense RNA 2 Neighboring gene suppressor of cytokine signaling 6 pseudogene Neighboring gene uncharacterized LOC124902729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5355 Neighboring gene lactate dehydrogenase A like 6D, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:83769989-83771188 Neighboring gene NANOG hESC enhancer GRCh37_chr11:83868528-83869174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5357 Neighboring gene uncharacterized LOC105369416 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 72 Neighboring gene NANOG hESC enhancer GRCh37_chr11:84384719-84385229 Neighboring gene uncharacterized LOC124902727 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:84505287-84505788 Neighboring gene ribosomal protein L9 pseudogene 22 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5359 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5360 Neighboring gene REST corepressor 1 pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:85059939-85060760 Neighboring gene DExH-box helicase 9 pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:85181858-85182577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:85183649-85184545 Neighboring gene Sharpr-MPRA regulatory region 9338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:85250835-85251373 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:85248765-85249264 Neighboring gene RNA, U6 small nuclear 1292, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:85317081-85318280 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:85319023-85319982 Neighboring gene MPRA-validated peak1373 silencer Neighboring gene MPRA-validated peak1374 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:85338434-85338942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5367 Neighboring gene transmembrane protein 126B Neighboring gene transmembrane protein 126A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Enhancing DLG2 Implications in Neuropsychiatric Disorders: Analysis of a Cohort of Eight Patients with 11q14.1 Imbalances. Bertini V, et al. Genes (Basel), 2022 May 12. PMID 35627244, Free PMC Article
  2. DLG2 impairs dsDNA break repair and maintains genome integrity in neuroblastoma. Keane S, et al. DNA Repair (Amst), 2022 Apr. PMID 35217496
  3. Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Sanders B, et al. Nat Commun, 2022 Jan 14. PMID 35031607, Free PMC Article
  4. DLG2 Mutations in the Etiology of Pubertal Delay and Idiopathic Hypogonadotropic Hypogonadism. Turan I, et al. Horm Res Paediatr, 2021. PMID 34695822
  5. DLG2 variants in patients with pubertal disorders. Jee YH, et al. Genet Med, 2020 Aug. PMID 32341572, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glioma stem cell-derived exosomes induce the transformation of astrocytes via the miR-3065-5p/DLG2 signaling axis.
    Title: Glioma stem cell-derived exosomes induce the transformation of astrocytes via the miR-3065-5p/DLG2 signaling axis.
  2. DLG2 intragenic exonic deletions reinforce the link to neurodevelopmental disorders and suggest a potential association with congenital anomalies and dysmorphism.
    Title: DLG2 intragenic exonic deletions reinforce the link to neurodevelopmental disorders and suggest a potential association with congenital anomalies and dysmorphism.
  3. Enhancing DLG2 Implications in Neuropsychiatric Disorders: Analysis of a Cohort of Eight Patients with 11q14.1 Imbalances.
    Title: Enhancing DLG2 Implications in Neuropsychiatric Disorders: Analysis of a Cohort of Eight Patients with 11q14.1 Imbalances.
  4. Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.
    Title: Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.
  5. DLG2 impairs dsDNA break repair and maintains genome integrity in neuroblastoma.
    Title: DLG2 impairs dsDNA break repair and maintains genome integrity in neuroblastoma.
  6. DLG2 Mutations in the Etiology of Pubertal Delay and Idiopathic Hypogonadotropic Hypogonadism.
    Title: DLG2 Mutations in the Etiology of Pubertal Delay and Idiopathic Hypogonadotropic Hypogonadism.
  7. Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.
    Title: Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.
  8. Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival.
    Title: Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival.
  9. SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.
    Title: SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.
  10. DLG2 variants in patients with pubertal disorders.
    Title: DLG2 variants in patients with pubertal disorders.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2018-11-28)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2018-11-28)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
EBI GWAS Catalog
A genome-wide association study identifies susceptibility loci for Wilms tumor.
EBI GWAS Catalog
A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.
EBI GWAS Catalog
Genome wide association scan for chronic periodontitis implicates novel locus.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog
Genome-wide association with bone mass and geometry in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data.
EBI GWAS Catalog
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37266, MGC131811, DKFZp781D1854, DKFZp781E0954

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanylate kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables ionotropic glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in GDP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GMP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in anterograde axonal protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to potassium ion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryo development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of epithelial cell apical/basal polarity NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor localization to synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde axonal protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in adherens junction NAS
Non-traceable Author Statement
more info
 PubMed 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in juxtaparanode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
disks large homolog 2
Names
channel-associated protein of synapse-110
channel-associated protein of synapses, 110kDa
discs, large homolog 2, chapsyn-110
postsynaptic density protein PSD-93
protein phosphatase 1, regulatory subunit 58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021375.2 RefSeqGene

    Range
    6192..2178363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142699.3 → NP_001136171.1  disks large homolog 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC023118, AP000639, AP000642, AP000773, AP001791, AP002370, AP002751, AP002797, AP002803, AP002878, AP003026, AP003093, AP003305
    Consensus CDS
    CCDS44690.1
    UniProtKB/TrEMBL
    A0A3B3ITF1
    Related
    ENSP00000365272.2, ENST00000376104.7
    Conserved Domains (7) summary
    cd12032
    Location:639 → 712
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    smart00072
    Location:795 → 962
    GuKc; Guanylate kinase homologues
    cd00992
    Location:524 → 602
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:784 → 962
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:383 → 450
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:120 → 202
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cl02672
    Location:1 → 25
    L27; L27 domain

  2. NM_001142700.2 → NP_001136172.1  disks large homolog 2 isoform 3

    See identical proteins and their annotated locations for NP_001136172.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a distinct 5' UTR and coding region, lacks three coding exons, and includes an alternate coding exon, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK126776, AP003026, BM678399
    Consensus CDS
    CCDS44691.1
    UniProtKB/TrEMBL
    F8VYC1
    Related
    ENSP00000402275.2, ENST00000418306.6
    Conserved Domains (5) summary
    cd12032
    Location:431 → 504
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    smart00072
    Location:569 → 736
    GuKc; Guanylate kinase homologues
    cd00992
    Location:316 → 394
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:558 → 736
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:227 → 290
    PDZ_assoc; PDZ-associated domain of NMDA receptors

  3. NM_001142702.2 → NP_001136174.1  disks large homolog 2 isoform 4

    See identical proteins and their annotated locations for NP_001136174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses a distinct 5' UTR, lacks an in-frame portion of the 5' coding region, and uses an alternate splice pattern in the central coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus and differs at an internal segment, compared to isoform 1.
    Source sequence(s)
    AP000773, AP002370, AP003026
    Consensus CDS
    CCDS44692.1
    UniProtKB/Swiss-Prot
    Q15700
    Related
    ENSP00000393049.2, ENST00000426717.6
    Conserved Domains (2) summary
    pfam00625
    Location:143 → 321
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:16 → 89
    SH3; Src Homology 3 domain superfamily

  4. NM_001206769.2 → NP_001193698.1  disks large homolog 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. Isoform 5 has a distinct N-terminus and is compared to isoform 1.
    Source sequence(s)
    AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
    Consensus CDS
    CCDS55782.1
    UniProtKB/TrEMBL
    B7Z264
    Related
    ENSP00000280241.8, ENST00000280241.12
    Conserved Domains (6) summary
    cd12032
    Location:573 → 646
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    smart00072
    Location:729 → 896
    GuKc; Guanylate kinase homologues
    cd00992
    Location:458 → 536
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:718 → 896
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:317 → 384
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:45 → 136
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  5. NM_001300983.1 → NP_001287912.1  disks large homolog 2 isoform 6

    See identical proteins and their annotated locations for NP_001287912.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (6) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK295094, AP003026
    Consensus CDS
    CCDS73357.1
    UniProtKB/TrEMBL
    B7Z264, B7Z2T4
    Related
    ENSP00000435849.1, ENST00000532653.5
    Conserved Domains (6) summary
    cd12032
    Location:534 → 607
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    smart00072
    Location:672 → 839
    GuKc; Guanylate kinase homologues
    cd00992
    Location:419 → 497
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:661 → 839
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:278 → 345
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:14 → 97
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  6. NM_001351274.2 → NP_001338203.1  disks large homolog 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000642, AP000773, AP001791, AP002370, AP002751, AP002797, AP002803, AP002878, AP003026, AP003093, AP003305
    Consensus CDS
    CCDS91566.1
    UniProtKB/TrEMBL
    A0A3B3ITF1, A0A994J819
    Related
    ENSP00000516284.1, ENST00000706226.1
    Conserved Domains (6) summary
    cd12032
    Location:651 → 724
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00992
    Location:536 → 614
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:778 → 956
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:4 → 62
    L27_1; L27_1
    pfam10600
    Location:395 → 462
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:132 → 214
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  7. NM_001351275.2 → NP_001338204.1  disks large homolog 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000642, AP000773, AP001791, AP002370, AP002751, AP002797, AP002803, AP002878, AP003026, AP003093, AP003305
    Consensus CDS
    CCDS91565.1
    UniProtKB/TrEMBL
    A0A3B3ITF1, A0A994J7P1
    Related
    ENSP00000516288.1, ENST00000706233.1
    Conserved Domains (6) summary
    cd12032
    Location:650 → 723
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00992
    Location:535 → 613
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:777 → 955
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:4 → 62
    L27_1; L27_1
    pfam10600
    Location:394 → 461
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:132 → 213
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  8. NM_001351276.2 → NP_001338205.1  disks large homolog 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000773, AP001791, AP001825, AP002370, AP002751, AP002797, AP003026, AP003305
    UniProtKB/TrEMBL
    B7Z264
    Conserved Domains (5) summary
    cd12032
    Location:553 → 626
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00992
    Location:438 → 516
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:680 → 858
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:297 → 364
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:34 → 116
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  9. NM_001364.3 → NP_001355.2  disks large homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001355.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a distinct 5' UTR and coding region, compared to variant 1. The resulting isoform (2), also known as alpha, has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB209252, AP003026, BM678399, CR749820, DA778233
    Consensus CDS
    CCDS41696.1
    UniProtKB/Swiss-Prot
    B7WNY8, F8W9V6, Q15700, Q59G57, Q5H9Q4, Q68CQ8, Q6ZTA8
    UniProtKB/TrEMBL
    B7Z264
    Related
    ENSP00000381355.2, ENST00000398309.6
    Conserved Domains (6) summary
    cd12032
    Location:534 → 607
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    smart00072
    Location:690 → 857
    GuKc; Guanylate kinase homologues
    cd00992
    Location:419 → 497
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:679 → 857
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:278 → 345
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:14 → 97
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  10. NM_001377966.1 → NP_001364895.1  disks large homolog 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
    UniProtKB/TrEMBL
    B7Z264
    Conserved Domains (5) summary
    cd12032
    Location:573 → 646
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00992
    Location:458 → 536
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:718 → 890
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:317 → 384
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:45 → 136
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  11. NM_001377967.1 → NP_001364896.1  disks large homolog 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
    Consensus CDS
    CCDS91558.1
    UniProtKB/TrEMBL
    A0A994J822, B7Z264
    Related
    ENSP00000516291.1, ENST00000706243.1
    Conserved Domains (5) summary
    cd12032
    Location:573 → 646
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00992
    Location:458 → 536
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:700 → 878
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:317 → 384
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:45 → 136
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  12. NM_001377968.1 → NP_001364897.1  disks large homolog 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000773, AP000857, AP001791, AP002370, AP002751, AP002797, AP003026, AP003305
    Consensus CDS
    CCDS91563.1
    UniProtKB/TrEMBL
    B7Z264, E9PN83
    Related
    ENSP00000432894.1, ENST00000524982.5
    Conserved Domains (5) summary
    cd12032
    Location:534 → 607
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00992
    Location:419 → 497
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:675 → 853
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:278 → 345
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:14 → 97
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  13. NM_001377970.1 → NP_001364899.1  disks large homolog 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
    Consensus CDS
    CCDS91557.1
    UniProtKB/TrEMBL
    A0A994J5T6, B7Z264
    Related
    ENSP00000516282.1, ENST00000706204.1
    Conserved Domains (5) summary
    cd12032
    Location:521 → 594
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00992
    Location:406 → 484
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:666 → 844
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:317 → 380
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:45 → 136
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  14. NM_001377971.1 → NP_001364900.1  disks large homolog 2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
    UniProtKB/TrEMBL
    B7Z264
    Conserved Domains (5) summary
    cd12032
    Location:521 → 594
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00992
    Location:406 → 484
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:648 → 826
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:317 → 380
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:45 → 136
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  15. NM_001377972.1 → NP_001364901.1  disks large homolog 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
    UniProtKB/TrEMBL
    F8VYC1
    Related
    ENSP00000381353.4, ENST00000330014.11
    Conserved Domains (5) summary
    cd12032
    Location:501 → 574
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00992
    Location:386 → 464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:628 → 806
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:245 → 312
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:36 → 64
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  16. NM_001377973.1 → NP_001364902.1  disks large homolog 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000773, AP001791, AP002370, AP002751, AP002797, AP003026, AP003305
    Consensus CDS
    CCDS91559.1
    UniProtKB/TrEMBL
    A0A5F9ZH92, B7Z264
    Related
    ENSP00000500169.2, ENST00000527466.2
    Conserved Domains (5) summary
    cd12032
    Location:492 → 565
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00992
    Location:377 → 455
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:619 → 797
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:236 → 303
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:24 → 55
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  17. NM_001377974.1 → NP_001364903.1  disks large homolog 2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
    UniProtKB/TrEMBL
    F8VYC1
    Conserved Domains (5) summary
    cd12032
    Location:449 → 522
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00992
    Location:334 → 412
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:576 → 754
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:245 → 308
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:36 → 64
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  18. NM_001377975.1 → NP_001364904.1  disks large homolog 2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000773, AP002370, AP002751, AP002797, AP003305
    Consensus CDS
    CCDS91556.1
    UniProtKB/TrEMBL
    A0A994J570, A0A994J7N9
    Related
    ENSP00000516287.1, ENST00000706232.1
    Conserved Domains (3) summary
    cd00992
    Location:386 → 464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam10600
    Location:245 → 312
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:36 → 64
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  19. NM_001377976.1 → NP_001364905.1  disks large homolog 2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AP000773, AP002370, AP003026
    Conserved Domains (2) summary
    pfam00625
    Location:172 → 350
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:45 → 118
    SH3; Src Homology 3 domain superfamily

  20. NM_001377977.1 → NP_001364906.1  disks large homolog 2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AP000773, AP002370, AP003026
    Conserved Domains (2) summary
    pfam00625
    Location:170 → 348
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:43 → 116
    SH3; Src Homology 3 domain superfamily

  21. NM_001377978.1 → NP_001364907.1  disks large homolog 2 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AP000773, AP002370, AP003026
    Conserved Domains (2) summary
    pfam00625
    Location:161 → 339
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:16 → 89
    SH3; Src Homology 3 domain superfamily

  22. NM_001377979.1 → NP_001364908.1  disks large homolog 2 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AP000773, AP002370, AP003026
    Consensus CDS
    CCDS91555.1
    UniProtKB/TrEMBL
    B5MCC5, B7Z640
    Related
    ENSP00000385113.3, ENST00000404783.7
    Conserved Domains (2) summary
    pfam00625
    Location:157 → 335
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:16 → 89
    SH3; Src Homology 3 domain superfamily

  23. NM_001377980.1 → NP_001364909.1  disks large homolog 2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AP000773, AP002370, AP003026
    Conserved Domains (2) summary
    pfam00625
    Location:143 → 315
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:16 → 89
    SH3; Src Homology 3 domain superfamily

  24. NM_001377981.1 → NP_001364910.1  disks large homolog 2 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AP000773, AP002370, AP003026
    Conserved Domains (2) summary
    pfam00625
    Location:126 → 304
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:16 → 89
    SH3; Src Homology 3 domain superfamily

  25. NM_001377982.1 → NP_001364911.1  disks large homolog 2 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AP000773, AP002370, AP003026
    Conserved Domains (1) summary
    pfam00625
    Location:84 → 262
    Guanylate_kin; Guanylate kinase

  26. NM_001377983.1 → NP_001364912.1  disks large homolog 2 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP002797, AP003305
    Conserved Domains (2) summary
    cd00992
    Location:137 → 221
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam10608
    Location:45 → 136
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RNA

  1. NR_165353.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
    Related
    ENST00000706203.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    83455012..85628373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017256.3 → XP_016872745.1  disks large homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A3B3ITF1

  2. XM_047426494.1 → XP_047282450.1  disks large homolog 2 isoform X1

  3. XM_017017257.3 → XP_016872746.1  disks large homolog 2 isoform X4

    UniProtKB/TrEMBL
    A0A3B3ITF1

  4. XM_047426498.1 → XP_047282454.1  disks large homolog 2 isoform X8

  5. XM_047426496.1 → XP_047282452.1  disks large homolog 2 isoform X5

  6. XM_047426495.1 → XP_047282451.1  disks large homolog 2 isoform X3

  7. XM_047426499.1 → XP_047282455.1  disks large homolog 2 isoform X9

  8. XM_047426497.1 → XP_047282453.1  disks large homolog 2 isoform X6

  9. XM_017017255.3 → XP_016872744.1  disks large homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A3B3ITF1

  10. XM_017017258.2 → XP_016872747.1  disks large homolog 2 isoform X7

    UniProtKB/TrEMBL
    A0A3B3ITF1

  11. XM_017017285.2 → XP_016872774.1  disks large homolog 2 isoform X31

    UniProtKB/TrEMBL
    B7Z264

  12. XM_017017276.2 → XP_016872765.1  disks large homolog 2 isoform X22

    UniProtKB/TrEMBL
    B7Z264

  13. XM_017017269.2 → XP_016872758.1  disks large homolog 2 isoform X18

    UniProtKB/TrEMBL
    B7Z264

  14. XM_017017280.3 → XP_016872769.1  disks large homolog 2 isoform X29

    UniProtKB/TrEMBL
    B7Z264

  15. XM_017017279.2 → XP_016872768.1  disks large homolog 2 isoform X27

    UniProtKB/TrEMBL
    B7Z264, E9PIJ9
    Related
    ENSP00000435809.2, ENST00000527088.2

  16. XM_017017270.2 → XP_016872759.1  disks large homolog 2 isoform X19

    UniProtKB/TrEMBL
    B7Z264

  17. XM_011544782.3 → XP_011543084.1  disks large homolog 2 isoform X14

    UniProtKB/TrEMBL
    A0A3B3ITF1
    Conserved Domains (6) summary
    cd12032
    Location:555 → 628
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    smart00072
    Location:711 → 878
    GuKc; Guanylate kinase homologues
    cd00992
    Location:440 → 518
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:700 → 878
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:299 → 366
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:36 → 118
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  18. XM_017017263.2 → XP_016872752.1  disks large homolog 2 isoform X11

    UniProtKB/TrEMBL
    A0A3B3ITF1

  19. XM_017017268.2 → XP_016872757.1  disks large homolog 2 isoform X17

    UniProtKB/TrEMBL
    B7Z264

  20. XM_017017267.2 → XP_016872756.1  disks large homolog 2 isoform X16

    UniProtKB/TrEMBL
    B7Z264
    Conserved Domains (6) summary
    cd12032
    Location:534 → 607
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    smart00072
    Location:704 → 871
    GuKc; Guanylate kinase homologues
    cd00992
    Location:419 → 497
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:693 → 871
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:278 → 345
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:14 → 97
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  21. XM_017017265.3 → XP_016872754.1  disks large homolog 2 isoform X13

    UniProtKB/TrEMBL
    B7Z264
    Conserved Domains (3) summary
    cd12032
    Location:553 → 626
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    smart00072
    Location:723 → 890
    GuKc; Guanylate kinase homologues
    cd00992
    Location:438 → 516
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  22. XM_017017281.3 → XP_016872770.1  disks large homolog 2 isoform X28

    UniProtKB/TrEMBL
    A0A994J587, B7Z264
    Related
    ENSP00000516312.1, ENST00000706266.1

  23. XM_047426502.1 → XP_047282458.1  disks large homolog 2 isoform X24

  24. XM_017017271.3 → XP_016872760.1  disks large homolog 2 isoform X20

    UniProtKB/TrEMBL
    A0A994J7Q5, B7Z264
    Related
    ENSP00000516313.1, ENST00000706267.1

  25. XM_047426500.1 → XP_047282456.1  disks large homolog 2 isoform X15

    UniProtKB/TrEMBL
    A0A3B3ISW2
    Related
    ENSP00000497475.1, ENST00000648622.1

  26. XM_017017264.3 → XP_016872753.1  disks large homolog 2 isoform X12

    UniProtKB/TrEMBL
    B7Z264

  27. XM_047426505.1 → XP_047282461.1  disks large homolog 2 isoform X32

  28. XM_047426503.1 → XP_047282459.1  disks large homolog 2 isoform X26

  29. XM_017017277.2 → XP_016872766.1  disks large homolog 2 isoform X23

    UniProtKB/TrEMBL
    B7Z264

  30. XM_017017273.3 → XP_016872762.1  disks large homolog 2 isoform X21

    UniProtKB/TrEMBL
    B7Z264

  31. XM_017017262.2 → XP_016872751.1  disks large homolog 2 isoform X10

    UniProtKB/TrEMBL
    B7Z264

  32. XM_005273810.5 → XP_005273867.1  disks large homolog 2 isoform X25

    UniProtKB/TrEMBL
    E9PIW2
    Related
    ENSP00000433848.1, ENST00000531015.5
    Conserved Domains (6) summary
    cd12032
    Location:501 → 574
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    smart00072
    Location:657 → 824
    GuKc; Guanylate kinase homologues
    cd00992
    Location:386 → 464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:646 → 824
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:245 → 312
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:36 → 64
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  33. XM_017017284.2 → XP_016872773.1  disks large homolog 2 isoform X30

    UniProtKB/TrEMBL
    B7Z264

  34. XM_017017287.2 → XP_016872776.1  disks large homolog 2 isoform X34

  35. XM_017017289.2 → XP_016872778.1  disks large homolog 2 isoform X35

    Conserved Domains (2) summary
    pfam00625
    Location:202 → 380
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:43 → 116
    SH3; Src Homology 3 domain superfamily

  36. XM_017017290.2 → XP_016872779.1  disks large homolog 2 isoform X36

    Conserved Domains (2) summary
    pfam00625
    Location:175 → 353
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:16 → 89
    SH3; Src Homology 3 domain superfamily

  37. XM_047426506.1 → XP_047282462.1  disks large homolog 2 isoform X33

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    83391509..85565050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367893.1 → XP_054223868.1  disks large homolog 2 isoform X2

  2. XM_054367891.1 → XP_054223866.1  disks large homolog 2 isoform X1

  3. XM_054367895.1 → XP_054223870.1  disks large homolog 2 isoform X4

  4. XM_054367899.1 → XP_054223874.1  disks large homolog 2 isoform X8

  5. XM_054367896.1 → XP_054223871.1  disks large homolog 2 isoform X5

  6. XM_054367894.1 → XP_054223869.1  disks large homolog 2 isoform X3

  7. XM_054367900.1 → XP_054223875.1  disks large homolog 2 isoform X9

  8. XM_054367897.1 → XP_054223872.1  disks large homolog 2 isoform X6

  9. XM_054367892.1 → XP_054223867.1  disks large homolog 2 isoform X2

  10. XM_054367898.1 → XP_054223873.1  disks large homolog 2 isoform X7

  11. XM_054367920.1 → XP_054223895.1  disks large homolog 2 isoform X29

  12. XM_054367918.1 → XP_054223893.1  disks large homolog 2 isoform X27

    UniProtKB/TrEMBL
    E9PIJ9

  13. XM_054367902.1 → XP_054223877.1  disks large homolog 2 isoform X11

  14. XM_054367922.1 → XP_054223897.1  disks large homolog 2 isoform X31

  15. XM_054367909.1 → XP_054223884.1  disks large homolog 2 isoform X18

  16. XM_054367910.1 → XP_054223885.1  disks large homolog 2 isoform X19

  17. XM_054367905.1 → XP_054223880.1  disks large homolog 2 isoform X14

  18. XM_054367913.1 → XP_054223888.1  disks large homolog 2 isoform X22

  19. XM_054367908.1 → XP_054223883.1  disks large homolog 2 isoform X17

  20. XM_054367907.1 → XP_054223882.1  disks large homolog 2 isoform X16

  21. XM_054367904.1 → XP_054223879.1  disks large homolog 2 isoform X13

  22. XM_054367919.1 → XP_054223894.1  disks large homolog 2 isoform X28

    UniProtKB/TrEMBL
    A0A994J587

  23. XM_054367915.1 → XP_054223890.1  disks large homolog 2 isoform X24

  24. XM_054367911.1 → XP_054223886.1  disks large homolog 2 isoform X20

    UniProtKB/TrEMBL
    A0A994J7Q5

  25. XM_054367906.1 → XP_054223881.1  disks large homolog 2 isoform X15

    UniProtKB/TrEMBL
    A0A3B3ISW2

  26. XM_054367903.1 → XP_054223878.1  disks large homolog 2 isoform X12

  27. XM_054367923.1 → XP_054223898.1  disks large homolog 2 isoform X32

  28. XM_054367917.1 → XP_054223892.1  disks large homolog 2 isoform X26

  29. XM_054367914.1 → XP_054223889.1  disks large homolog 2 isoform X23

  30. XM_054367912.1 → XP_054223887.1  disks large homolog 2 isoform X21

  31. XM_054367901.1 → XP_054223876.1  disks large homolog 2 isoform X10

  32. XM_054367916.1 → XP_054223891.1  disks large homolog 2 isoform X25

  33. XM_054367921.1 → XP_054223896.1  disks large homolog 2 isoform X30

  34. XM_054367924.1 → XP_054223899.1  disks large homolog 2 isoform X37

  35. XM_054367926.1 → XP_054223901.1  disks large homolog 2 isoform X34

  36. XM_054367927.1 → XP_054223902.1  disks large homolog 2 isoform X35

  37. XM_054367925.1 → XP_054223900.1  disks large homolog 2 isoform X33

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175892.3: Suppressed sequence

    Description
    NM_175892.3: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15700.3 GenPept UniProtKB/Swiss-Prot:Q15700

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