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cdc-14 Tyrosine-protein phosphatase cdc-14 [ Caenorhabditis elegans ]

Gene ID: 173945, updated on 5-May-2024

Summary

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Gene symbol
cdc-14
Gene description
Tyrosine-protein phosphatase cdc-14
Primary source
WormBase:WBGene00000383
Locus tag
CELE_C17G10.4
See related
AllianceGenome:WB:WBGene00000383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables phosphoprotein phosphatase activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; mitotic spindle midzone assembly; and regulation of cell cycle process. Located in microtubule cytoskeleton; midbody; and nucleolus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to several human genes including CDC14A (cell division cycle 14A) and CDC14B (cell division cycle 14B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (5589038..5593427, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene LYSozyme Neighboring gene THAP-type domain-containing protein Neighboring gene Cns1/TTC4 wheel domain-containing protein Neighboring gene uS12 prolyl 3-hydroxylase Neighboring gene DUF4440 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell-cycle control in Caenorhabditis elegans: how the worm moves from G1 to S. Koreth J, et al. Oncogene, 2005 Apr 18. PMID 15838512
  2. Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans. Roy SH, et al. Mech Dev, 2011 Sep-Dec. PMID 21723944, Free PMC Article
  3. Cell division: timing the machine. Bowerman B. Nature, 2004 Aug 19. PMID 15318203
  4. Developmental quiescence: Cdc14 moonlighting in G1. Kipreos ET. Nat Cell Biol, 2004 Aug. PMID 15303097
  5. Cell cycle regulation of central spindle assembly. Mishima M, et al. Nature, 2004 Aug 19. PMID 15282614

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans.
    Title: Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans.
  2. cdc-14 control developmental cell-cycle arrest in C. elegans.
    Title: The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polar body extrusion after meiotic divisions IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G1 to G0 transition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of G1 to G0 transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of exit from mitosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in astral microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular non-membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinociliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
located_in spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tyrosine-protein phosphatase cdc-14
NP_001021969.1
  • Confirmed by transcript evidence
NP_001300510.1
  • Confirmed by transcript evidence
NP_001367521.1
  • Confirmed by transcript evidence
NP_001368512.1
  • Confirmed by transcript evidence
NP_001370451.1
  • Confirmed by transcript evidence
NP_001379687.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5589038..5593427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026798.8 → NP_001021969.1  Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021969.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P81299
    Conserved Domains (3) summary
    COG2453
    Location:192 → 347
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:23 → 169
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:229 → 348
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_001393076.1 → NP_001379687.1  Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam05109
    Location:407 → 644
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14499
    Location:180 → 352
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:19 → 171
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  3. NM_001383840.2 → NP_001370451.1  Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam05109
    Location:407 → 644
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14499
    Location:180 → 352
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:19 → 171
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  4. NM_001313581.4 → NP_001300510.1  Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3AQY3, A0A0K3ATW0, P81299, P81300, Q09955, Q09976, Q6DLY2, Q6DLY3, Q6DLY4, Q6DLY5, Q6DLY6, Q8MQD6
    Conserved Domains (3) summary
    COG2453
    Location:192 → 347
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:21 → 170
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl25496
    Location:410 → 656
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  5. NM_001381422.2 → NP_001367521.1  Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam05109
    Location:465 → 648
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14499
    Location:180 → 352
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:19 → 171
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  6. NM_001381423.2 → NP_001368512.1  Tyrosine-protein phosphatase cdc-14 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam05109
    Location:465 → 662
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14499
    Location:180 → 352
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:19 → 171
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P81299.3

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