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Mmp15 matrix metallopeptidase 15 [ Mus musculus (house mouse) ]

Gene ID: 17388, updated on 12-May-2024

Summary

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Official Symbol
Mmp15provided by MGI
Official Full Name
matrix metallopeptidase 15provided by MGI
Primary source
MGI:MGI:109320
See related
Ensembl:ENSMUSG00000031790 AllianceGenome:MGI:109320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MT2-MMP; MT-MMP 2
Summary
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. A deficiency of the encoded protein in mice is compatible with normal development and postnatal growth. [provided by RefSeq, Feb 2016]
Expression
Broad expression in lung adult (RPKM 64.4), colon adult (RPKM 55.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C5; 8 47.12 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96078924..96100921)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95352296..95374293)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E8259 Neighboring gene zinc finger protein 319 Neighboring gene U6 snRNA biogenesis 1 Neighboring gene VISTA enhancer mm71 Neighboring gene cilia and flagella associated protein 20 Neighboring gene STARR-positive B cell enhancer ABC_E245 Neighboring gene casein kinase 2, alpha prime polypeptide Neighboring gene STARR-seq mESC enhancer starr_22388

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation of a promoter region in mouse cytochrome P450 3A (Cyp3A16) gene and its transcriptional control. Itoh S, et al. Biochim Biophys Acta, 1997 Feb 7. PMID 9048885
  2. Isolation of a mouse MT2-MMP gene from a lung cDNA library and identification of its product. Tanaka M, et al. FEBS Lett, 1997 Feb 3. PMID 9037199
  3. Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1. Ota I, et al. Proc Natl Acad Sci U S A, 2009 Dec 1. PMID 19915148, Free PMC Article
  4. Functional roles of MMP14 and MMP15 in early postnatal mammary gland development. Feinberg TY, et al. Development, 2016 Nov 1. PMID 27633994, Free PMC Article
  5. MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding. Sanz RL, et al. J Neurosci, 2018 Jan 17. PMID 29196321, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
matrix metalloproteinase-15
Names
Membrane type 2-MMP
membrane-type-2 matrix metalloproteinase
NP_032635.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008609.4 → NP_032635.1  matrix metalloproteinase-15 preproprotein

    See identical proteins and their annotated locations for NP_032635.1

    Status: REVIEWED

    Source sequence(s)
    BC047278, BY732226
    Consensus CDS
    CCDS22561.1
    UniProtKB/Swiss-Prot
    O54732
    Related
    ENSMUSP00000034243.6, ENSMUST00000034243.7
    Conserved Domains (5) summary
    cd00094
    Location:363 → 555
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:135 → 300
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:134 → 300
    Peptidase_M10; Matrixin
    pfam01471
    Location:43 → 102
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:632 → 657
    DUF3377; Domain of unknown function (DUF3377)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    96078924..96100921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54732.1 GenPept UniProtKB/Swiss-Prot:O54732

Gene LinkOut

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