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Mmp13 matrix metallopeptidase 13 [ Mus musculus (house mouse) ]

Gene ID: 17386, updated on 13-Apr-2024

Summary

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Official Symbol
Mmp13provided by MGI
Official Full Name
matrix metallopeptidase 13provided by MGI
Primary source
MGI:MGI:1340026
See related
Ensembl:ENSMUSG00000050578 AllianceGenome:MGI:1340026
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clg; Mmp1; MMP-13
Summary
This gene encodes a member of the matrix metalloproteinase family that plays a role in wound healing, skeletal development and bone remodeling. The encoded protein is activated by the removal of an N-terminal activation peptide to generate a zinc-dependent endopeptidase enzyme that can cleave various native collagens, including types I - IV, X and XIV. Mice lacking the encoded protein display profound defects in growth plate cartilage as well as a delay in the endochondral bone development. Lack of the encoded protein also impairs the wound healing process due to reduced keratinocyte migration and vascular density at the wound site. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Jun 2015]
Expression
Biased expression in CNS E18 (RPKM 1.3), limb E14.5 (RPKM 0.9) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Mmp13 in Genome Data Viewer
Location:
9 A1; 9 2.46 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7272514..7283333)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7272514..7283333)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 2 heavy chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E6712 Neighboring gene defective in cullin neddylation 1 domain containing 5 Neighboring gene predicted gene, 31639 Neighboring gene STARR-seq mESC enhancer starr_23207 Neighboring gene STARR-seq mESC enhancer starr_23208 Neighboring gene STARR-seq mESC enhancer starr_23209 Neighboring gene STARR-seq mESC enhancer starr_23210 Neighboring gene matrix metallopeptidase 12 Neighboring gene matrix metallopeptidase 1b (interstitial collagenase)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Role of Matrix Metalloproteinase-13 (MMP13) in TGFβ/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation. Liu M, et al. Cell Physiol Biochem, 2022 Dec 20. PMID 36537139
  2. MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma. Zhang W, et al. Comput Math Methods Med, 2022. PMID 36105241, Free PMC Article
  3. Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency. Ponte F, et al. Sci Rep, 2022 Jun 17. PMID 35715555, Free PMC Article
  4. dsRNA Induced IFNβ-MMP13 Axis Drives Corneal Wound Healing. Lan X, et al. Invest Ophthalmol Vis Sci, 2022 Feb 1. PMID 35129588, Free PMC Article
  5. Selective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic Lesions. Buchler A, et al. Mol Imaging Biol, 2022 Feb. PMID 34231104

See all (406) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Effects of miR-143 on the migration and invasion of osteosarcoma cells by regulating MMP-13 expression].
    Title: [Effects of miR-143 on the migration and invasion of osteosarcoma cells by regulating MMP-13 expression].
  2. MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/beta-catenin signaling via HIF-1alpha upregulation in mouse embryonic fibroblasts.
    Title: MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/β-catenin signaling via HIF-1α upregulation in mouse embryonic fibroblasts.
  3. Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin.
    Title: Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin.
  4. The Expression of MMP1 and MMP7 in Mice Liver after Exposure to Aflatoxin B1 Using Immunohistochemistry Technique.
    Title: The Expression of MMP1 and MMP7 in Mice Liver after Exposure to Aflatoxin B1 Using Immunohistochemistry Technique.
  5. MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy.
    Title: MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy.
  6. Genetic screening of MMP1 as a potential pathogenic gene in chronic obstructive pulmonary disease.
    Title: Genetic screening of MMP1 as a potential pathogenic gene in chronic obstructive pulmonary disease.
  7. The Role of Matrix Metalloproteinase-13 (MMP13) in TGFbeta/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation.
    Title: The Role of Matrix Metalloproteinase-13 (MMP13) in TGFβ/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation.
  8. MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma.
    Title: MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma.
  9. Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency.
    Title: Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency.
  10. STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts.
    Title: STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts.
Submit: New GeneRIF Correction See all GeneRIFs (153)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables collagen binding ISO
Inferred from Sequence Orthology
more info
  
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bone morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within collagen catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in collagen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in collagen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in endochondral ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within growth plate cartilage development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of pancreatic trypsinogen secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular canaliculus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
collagenase 3
Names
collagenase-1
interstitial collagenase
matrix metalloproteinase 13
NP_032633.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008607.2 → NP_032633.1  collagenase 3 preproprotein

    See identical proteins and their annotated locations for NP_032633.1

    Status: REVIEWED

    Source sequence(s)
    AC174457, AK150728, BC125320
    Consensus CDS
    CCDS22803.1
    UniProtKB/Swiss-Prot
    P33435
    UniProtKB/TrEMBL
    Q3U5R7, Q3U9V5
    Related
    ENSMUSP00000015394.9, ENSMUST00000015394.10
    Conserved Domains (4) summary
    cd00094
    Location:282 → 472
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:113 → 268
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:113 → 268
    Peptidase_M10; Matrixin
    pfam01471
    Location:33 → 92
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    7272514..7283333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33435.1 GenPept UniProtKB/Swiss-Prot:P33435

Gene LinkOut

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