Mmp10 matrix metallopeptidase 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mmp10provided by MGI
Official Full Name: matrix metallopeptidase 10provided by MGI
Primary source: MGI:MGI:97007
See related: Ensembl:ENSMUSG00000047562 AllianceGenome:MGI:97007
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SL-2; MMP-10
Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. The lack of encoded protein in mice promotes experimental lung cancer formation, exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]
Expression: Biased expression in large intestine adult (RPKM 4.9), duodenum adult (RPKM 2.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A1; 9 2.46 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (7502343..7510243)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (7502342..7510242)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Matrix metalloproteinase-10 deficiency has protective effects against peritoneal inflammation and fibrosis via transcription factor NFkappaBeta pathway inhibition.
Title: Matrix metalloproteinase-10 deficiency has protective effects against peritoneal inflammation and fibrosis via transcription factor NFκΒ pathway inhibition.
MMP10 alleviates non-alcoholic steatohepatitis by regulating macrophage M2 polarization.
Title: MMP10 alleviates non-alcoholic steatohepatitis by regulating macrophage M2 polarization.
Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue cancer.
Title: Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue cancer.
Expression of matrix metalloproteinase-3 and -10 is up-regulated in the periodontal tissues of aged mice.
Title: Expression of matrix metalloproteinase-3 and -10 is up-regulated in the periodontal tissues of aged mice.
Elevated MMP10/13 mediated barrier disruption and NF-kappaB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family knockout mice.
Title: Elevated MMP10/13 mediated barrier disruption and NF-κB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family knockout mice.
Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice.
Title: Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice.
Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria.
Title: Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria.
Our results suggest that MMP-10 facilitates H. pylori persistence and promotes gastritis.
Title: Helicobacter pylori-induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis.
MMP10 plays a role in atherosclerosis, favoring inflammation, development and complication of the plaque
Title: Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification.
These results indicate that MMP10 serves a beneficial role in response to acute infection by moderating the proinflammatory response of resident and infiltrating macrophages.
Title: Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

AV377895 (e-PCR)
- UniSTS:159851

NoName (e-PCR)
- UniSTS:491415

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: stromelysin-2

Names: matrix metalloproteinase 10; transin-2

NP_062344.1

EC 3.4.24.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019471.3 → NP_062344.1 stromelysin-2 preproprotein

See identical proteins and their annotated locations for NP_062344.1

Status: REVIEWED

Source sequence(s)

AK020292

Consensus CDS

CCDS22807.1

UniProtKB/Swiss-Prot

O55123

UniProtKB/TrEMBL

A1L3D0

Related

ENSMUSP00000034488.3, ENSMUST00000034488.4

Conserved Domains (4) summary

cd00094
Location:286 → 476

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:108 → 264

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:108 → 264

Peptidase_M10; Matrixin

pfam01471
Location:28 → 87

PG_binding_1; Putative peptidoglycan binding domain