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Mlf1 myeloid leukemia factor 1 [ Mus musculus (house mouse) ]

Gene ID: 17349, updated on 5-Mar-2024

Summary

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Official Symbol
Mlf1provided by MGI
Official Full Name
myeloid leukemia factor 1provided by MGI
Primary source
MGI:MGI:1341819
See related
Ensembl:ENSMUSG00000048416 AllianceGenome:MGI:1341819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HLS7
Summary
Enables DNA binding activity. Involved in myeloid progenitor cell differentiation and transcription, DNA-templated. Located in several cellular components, including ciliary basal body; ciliary base; and non-motile cilium. Is expressed in several structures, including brain; gonad; immune system; lung; and nasal cavity respiratory epithelium. Orthologous to human MLF1 (myeloid leukemia factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 137.0) and heart adult (RPKM 22.3) See more
Orthologs
human all
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Genomic context

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See Mlf1 in Genome Data Viewer
Location:
3 E1; 3 30.91 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (67281430..67307333)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (67374097..67400000)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07883 Neighboring gene arginine/serine-rich coiled-coil 1 Neighboring gene predicted gene, 54201 Neighboring gene predicted gene, 22295 Neighboring gene STARR-seq mESC enhancer starr_07884 Neighboring gene STARR-positive B cell enhancer ABC_E6060 Neighboring gene STARR-positive B cell enhancer mm9_chr3:67177807-67178108 Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene retinoic acid receptor responder (tazarotene induced) 1 Neighboring gene latexin Neighboring gene predicted gene, 40067

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice. Li ZF, et al. J Neurol Sci, 2008 Jan 15. PMID 17854834
  2. HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1. Williams JH, et al. EMBO J, 1999 Oct 15. PMID 10523300, Free PMC Article
  3. MLF1 is a proapoptotic antagonist of HOP complex-mediated survival. Sun Y, et al. Biochim Biophys Acta Mol Cell Res, 2017 Apr. PMID 28137643
  4. Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3. Sun Y, et al. J Physiol Biochem, 2015 Dec. PMID 26563351
  5. Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation. Yoneda-Kato N, et al. Mol Cell Biol, 2008 Jan. PMID 17967869, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data indicate that MLF1 serves as a proapoptotic antagonist that interacts with the HAX1/HtrA2-OMI/PARL (HOP) mitochondrial complex to modulate cell survival.
    Title: MLF1 is a proapoptotic antagonist of HOP complex-mediated survival.
  2. Ectopically expressed MLF1 could be responsible for the pathological apoptosis in early myelodysplastic syndrome (MDS) patients.
    Title: Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3.
  3. shuttling of MLF1 is critical for the regulation of cell proliferation and a disturbance in the shuttling balance increases the cell's susceptibility to oncogenic transformation
    Title: Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation.
  4. Mlf1 translocates between nucleus and cytoplasm, associates with a novel hnRNP, and influences gene expression
    Title: Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in myeloid progenitor cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_negative_effect regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ciliary base IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myeloid leukemia factor 1
Names
hematopoietic lineage switch 7
myelodysplasia-myeloid leukemia factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039543.2 → NP_001034632.1  myeloid leukemia factor 1 isoform a

    See identical proteins and their annotated locations for NP_001034632.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK133448, BC027526
    Consensus CDS
    CCDS17395.1
    UniProtKB/TrEMBL
    Q8JZS2
    Related
    ENSMUSP00000058596.9, ENSMUST00000061322.10
    Conserved Domains (1) summary
    pfam10248
    Location:27 → 217
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

  2. NM_010801.3 → NP_034931.2  myeloid leukemia factor 1 isoform b

    See identical proteins and their annotated locations for NP_034931.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AK133448, BC027526
    Consensus CDS
    CCDS17396.1
    UniProtKB/Swiss-Prot
    O70217, Q9QWV4
    UniProtKB/TrEMBL
    Q3V042
    Related
    ENSMUSP00000077072.6, ENSMUST00000077916.12
    Conserved Domains (1) summary
    pfam10248
    Location:27 → 202
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    67281430..67307333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QWV4.1 GenPept UniProtKB/Swiss-Prot:Q9QWV4

Gene LinkOut

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