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Mknk1 MAP kinase-interacting serine/threonine kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 17346, updated on 5-Mar-2024

Summary

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Official Symbol
Mknk1provided by MGI
Official Full Name
MAP kinase-interacting serine/threonine kinase 1provided by MGI
Primary source
MGI:MGI:894316
See related
Ensembl:ENSMUSG00000028708 AllianceGenome:MGI:894316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mnk1; 2410048M24Rik
Summary
This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Expression
Ubiquitous expression in thymus adult (RPKM 21.1), lung adult (RPKM 18.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D1; 4 53.06 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115695140..115736453)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115837943..115879256)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene MOB kinase activator 3C Neighboring gene STARR-seq mESC enhancer starr_11125 Neighboring gene STARR-positive B cell enhancer ABC_E1650 Neighboring gene STARR-positive B cell enhancer ABC_E6199 Neighboring gene kinocilin Neighboring gene transmembrane protein 275

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosis. Manne BK, et al. Blood, 2022 Dec 8. PMID 35930749, Free PMC Article
  2. Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice. Cendrowski J, et al. Gut, 2015 Jun. PMID 25037190
  3. Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1. Allard EK, et al. Neurobiol Dis, 2013 Oct. PMID 23742760
  4. Mnk Kinases in Cytokine Signaling and Regulation of Cytokine Responses. Joshi S, et al. Biomol Concepts, 2012 Apr. PMID 23710261, Free PMC Article
  5. Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity. Sandeman LY, et al. Mol Metab, 2020 Dec. PMID 32712434, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-370-3p Regulates Adipogenesis through Targeting Mknk1.
    Title: miR-370-3p Regulates Adipogenesis through Targeting Mknk1.
  2. Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity.
    Title: Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity.
  3. phosphorylation pattern of eIF4E responds faithfully to Rapamycin inhibition, the prolonged exposure to Rapamycin rescues the loss of eIF4E phosphorylation through Mnk1 activation.
    Title: Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1.
  4. MNK1 participates in mediating high-fat diet-induced insulin resistance. Our findings reveal distinct roles for the MNKs in a novel area of disease biology
    Title: MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.
  5. data suggest a physiological role for MNK1a-Ser(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.
    Title: AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a-dependent Phosphorylation of Eukaryotic Translation Initiation Factor 4E.
  6. Mnk1 is a novel pancreatic acinar cell-specific stress response kinase that regulates digestive enzyme abundance and eIF4E phosphorylation.
    Title: Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice.
  7. Long-term potentiation (LTP) consolidation in the dentate gyrus of live rodents requires sustained (hours) BDNF-TrkB signaling and from TrkB to MAP-kinase-interacting kinase.
    Title: Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK.
  8. Data suggest that Mnk1 and Mnk2 regulate cell migration/wound healing, expression of vimentin, stability of vimentin protein, and binding of eIF4E (eukaryotic translation initiation factor 4E) and Cyfip1 (cytoplasmic FMR1 interacting protein 1).
    Title: The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.
  9. Mnk1/2 has a minimal role in T cell development and activation but may regulate non-T cell lineages to control Th1 and Th17 differentiation in vivo.
    Title: Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
  10. oncogenic role for Mnk1/2 in tumor development
    Title: Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to salt stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MAP kinase-interacting serine/threonine-protein kinase 1
Names
MAPK signal-integrating kinase 1
NP_001272416.1
NP_001272417.1
NP_001342103.1
NP_001356167.1
NP_067436.1
XP_006502885.1
XP_006502888.1
XP_030109148.1
XP_036019677.1
XP_036019678.1
XP_036019679.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285487.1 → NP_001272416.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform a

    See identical proteins and their annotated locations for NP_001272416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK141298, AL627085, BB841753, BQ551007, BY209061, CN538557, CO425179
    UniProtKB/TrEMBL
    Q3TDV2, Q3U1I8
    Related
    ENSMUST00000144235.8
    Conserved Domains (1) summary
    cd14174
    Location:40 → 328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

  2. NM_001285488.1 → NP_001272417.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform b

    See identical proteins and their annotated locations for NP_001272417.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AK141298, AL627085, BQ551007, BY209061, CN538557, CO425179
    Consensus CDS
    CCDS18498.1
    UniProtKB/TrEMBL
    A2A8W8, Q3TDV2
    Related
    ENSMUSP00000102123.4, ENSMUST00000106513.10
    Conserved Domains (2) summary
    smart00220
    Location:41 → 321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14174
    Location:34 → 322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

  3. NM_001355174.1 → NP_001342103.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AK141298, BP762163, BQ551007, BY209061, CN538557, CO425179
    Conserved Domains (1) summary
    cd14174
    Location:34 → 322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

  4. NM_001369238.1 → NP_001356167.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL627085
    UniProtKB/TrEMBL
    Q3TDV2
    Conserved Domains (1) summary
    cl21453
    Location:34 → 290
    PKc_like; Protein Kinases, catalytic domain

  5. NM_021461.5 → NP_067436.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform b

    See identical proteins and their annotated locations for NP_067436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AK141298, BQ551007, BY209061, CN538557, CO425179
    Consensus CDS
    CCDS18498.1
    UniProtKB/TrEMBL
    A2A8W8, Q3TDV2
    Related
    ENSMUSP00000019677.6, ENSMUST00000019677.12
    Conserved Domains (2) summary
    smart00220
    Location:41 → 321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14174
    Location:34 → 322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115695140..115736453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163785.1 → XP_036019678.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

    Conserved Domains (1) summary
    cd14174
    Location:34 → 322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

  2. XM_006502822.4 → XP_006502885.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006502885.1

    UniProtKB/TrEMBL
    Q3TDV2, Q3U1I8
    Conserved Domains (1) summary
    cd14174
    Location:40 → 328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

  3. XM_006502825.4 → XP_006502888.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

    Conserved Domains (1) summary
    cd14174
    Location:40 → 328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

  4. XM_036163784.1 → XP_036019677.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

    UniProtKB/TrEMBL
    Q3TDV2
    Conserved Domains (1) summary
    cd14174
    Location:38 → 326
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

  5. XM_036163786.1 → XP_036019679.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:31 → 235
    PKc_like; Protein Kinases, catalytic domain

  6. XM_030253288.2 → XP_030109148.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

    Conserved Domains (1) summary
    cd14174
    Location:38 → 326
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08605.2 GenPept UniProtKB/Swiss-Prot:O08605

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