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gpdh-1 Glycerol-3-phosphate dehydrogenase [NAD(+)] [ Caenorhabditis elegans ]

Gene ID: 173272, updated on 11-Apr-2024

Summary

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Gene symbol
gpdh-1
Gene description
Glycerol-3-phosphate dehydrogenase [NAD(+)]
Primary source
WormBase:WBGene00009824
Locus tag
CELE_F47G4.3
See related
AllianceGenome:WB:WBGene00009824
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glycerol-3-phosphate dehydrogenase (quinone) activity and glycerol-3-phosphate dehydrogenase [NAD+] activity. Predicted to be involved in NADH oxidation and glycerol-3-phosphate metabolic process. Predicted to be part of glycerol-3-phosphate dehydrogenase complex. Predicted to be active in cytosol. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (14075837..14078211)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein zer-1 homolog Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans. Chandler-Brown D, et al. Front Genet, 2015. PMID 26579191, Free PMC Article
  2. Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress. Lamitina ST, et al. Am J Physiol Cell Physiol, 2004 Apr. PMID 14644776
  3. The JNK-like MAPK KGB-1 of Caenorhabditis elegans promotes reproduction, lifespan, and gene expressions for protein biosynthesis and germline homeostasis but interferes with hyperosmotic stress tolerance. Gerke P, et al. Cell Physiol Biochem, 2014. PMID 25500773
  4. Circadian stress tolerance in adult Caenorhabditis elegans. Simonetta SH, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2008 Sep. PMID 18648821
  5. FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores. Possik E, et al. PLoS Genet, 2015 Oct. PMID 26439621, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intestinal GPDH-1 regulates high glucose diet induced lifespan extension in aged worms.
    Title: Intestinal GPDH-1 regulates high glucose diet induced lifespan extension in aged worms.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase (quinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADH oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycerol-3-phosphate dehydrogenase (FAD) complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glycerol-3-phosphate dehydrogenase [NAD(+)]
NP_493454.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14075837..14078211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061053.8 → NP_493454.1  Glycerol-3-phosphate dehydrogenase [NAD(+)] [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493454.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XTS4
    Conserved Domains (3) summary
    TIGR03376
    Location:23 → 367
    glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
    pfam01210
    Location:23 → 199
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
    pfam07479
    Location:223 → 356
    NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
Nucleotide Protein
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