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Mgat1 mannoside acetylglucosaminyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 17308, updated on 21-Apr-2024

Summary

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Official Symbol
Mgat1provided by MGI
Official Full Name
mannoside acetylglucosaminyltransferase 1provided by MGI
Primary source
MGI:MGI:96973
See related
Ensembl:ENSMUSG00000020346 AllianceGenome:MGI:96973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mgat-1
Summary
Enables acetylglucosaminyltransferase activity. Acts upstream of or within UDP-N-acetylglucosamine catabolic process and in utero embryonic development. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including decidua; early conceptus; embryo ectoderm; embryo endoderm; and retina outer nuclear layer. Orthologous to human MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 29.2), spleen adult (RPKM 26.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.2; 11 29.27 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49135018..49153854)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49244191..49263027)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 62 Neighboring gene predicted gene, 18583 Neighboring gene STARR-positive B cell enhancer ABC_E6976 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49057557-49057744 Neighboring gene predicted gene, 51893 Neighboring gene STARR-positive B cell enhancer ABC_E195 Neighboring gene STARR-positive B cell enhancer ABC_E8994 Neighboring gene olfactory receptor family 2 subfamily Y member 1G Neighboring gene STARR-seq mESC enhancer starr_29373 Neighboring gene olfactory receptor family 2 subfamily Y member 1F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transgenic Rescue of Spermatogenesis in Males With Mgat1 Deleted in Germ Cells. Biswas B, et al. Front Cell Dev Biol, 2020. PMID 32300591, Free PMC Article
  2. Hepatic monoacylglycerol acyltransferase 1 is induced by prolonged food deprivation to modulate the hepatic fasting response. Lutkewitte AJ, et al. J Lipid Res, 2019 Mar. PMID 30610082, Free PMC Article
  3. Reduced myocyte complex N-glycosylation causes dilated cardiomyopathy. Ednie AR, et al. FASEB J, 2019 Jan. PMID 30138037, Free PMC Article
  4. MGAT1 and Complex N-Glycans Regulate ERK Signaling During Spermatogenesis. Biswas B, et al. Sci Rep, 2018 Jan 31. PMID 29386567, Free PMC Article
  5. Monoacylglycerol O-acyltransferase 1 (MGAT1) localizes to the ER and lipid droplets promoting triacylglycerol synthesis. Lee YJ, et al. BMB Rep, 2017 Jul. PMID 28347400, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mogat1 is a fasting-induced PPARalpha target gene that may feed forward to regulate liver PPARalpha activity during food deprivation
    Title: Hepatic monoacylglycerol acyltransferase 1 is induced by prolonged food deprivation to modulate the hepatic fasting response.
  2. Mgat1KO provides a model for investigating the relationship between systemic reductions in glycosylation and cardiac disease, showing that clinically relevant changes in cardiomyocyte hybrid/complex N-glycosylation are sufficient to cause DCM and early death
    Title: Reduced myocyte complex N-glycosylation causes dilated cardiomyopathy.
  3. MGAT1 activity may play a role in regulating basal adipocyte FFA retention
    Title: Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.
  4. MGAT1 is required to regulate ERK1/2 signaling during spermatogenesis, potentially via different mechanisms.
    Title: MGAT1 and Complex N-Glycans Regulate ERK Signaling During Spermatogenesis.
  5. The MGAT1 interacts with DGAT2, which serves to synergistically increase the TAG biosynthesis and LD expansion, leading to enhancement of lipid accumulation in the liver and fat.
    Title: Monoacylglycerol O-acyltransferase 1 (MGAT1) localizes to the ER and lipid droplets promoting triacylglycerol synthesis.
  6. this study shows that loss of O-GlcNAc transferase blocks T cell progenitor renewal, malignant transformation and peripheral T cell clonal expansion
    Title: Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy.
  7. Inhibition of hepatic Mogat1 improves hepatic metabolic abnormalities without attenuating liver inflammation and injury.
    Title: Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice.
  8. Data from transgenic mice suggest that a lack of complex N- and O-glycans impairs early embryo development and viability in vivo leading to delayed implantation and embryo loss; Mgat1 and C1galt1 are required for embryo development and implantation.
    Title: Embryos generated from oocytes lacking complex N- and O-glycans have compromised development and implantation.
  9. analysis of suppression of cancer progression by MGAT1 shRNA knockdown
    Title: Suppression of cancer progression by MGAT1 shRNA knockdown.
  10. the MGAT1 pathway induced by hepatic PPARgamma is critically important in the development of hepatic steatosis during diet-induced obesity
    Title: Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within UDP-N-acetylglucosamine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Names
GNT-I
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
glcNAc-T I
NP_001103618.1
NP_001103619.1
NP_001103620.1
NP_034924.3
XP_006532461.1
XP_006532462.1
XP_006532463.1
XP_017169803.1
XP_030101489.1
XP_030101490.1
XP_036012268.1
XP_036012269.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110148.1 → NP_001103618.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_001103618.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AI118268, AK040121, AL606829, BY088342
    Consensus CDS
    CCDS24602.1
    UniProtKB/Swiss-Prot
    P27808
    UniProtKB/TrEMBL
    Q544F0, Q8CIC9
    Related
    ENSMUSP00000126303.2, ENSMUST00000167400.8
    Conserved Domains (1) summary
    cl11394
    Location:12 → 446
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. NM_001110149.1 → NP_001103619.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_001103619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same isoform.
    Source sequence(s)
    AI118268, AK040121
    Consensus CDS
    CCDS24602.1
    UniProtKB/Swiss-Prot
    P27808
    UniProtKB/TrEMBL
    Q544F0, Q8CIC9
    Related
    ENSMUSP00000104817.2, ENSMUST00000109194.2
    Conserved Domains (1) summary
    cl11394
    Location:12 → 446
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  3. NM_001110150.1 → NP_001103620.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_001103620.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants encode the same isoform.
    Source sequence(s)
    AI118268, AK004760
    Consensus CDS
    CCDS24602.1
    UniProtKB/Swiss-Prot
    P27808
    UniProtKB/TrEMBL
    Q544F0, Q8CIC9
    Related
    ENSMUSP00000098851.5, ENSMUST00000101293.11
    Conserved Domains (1) summary
    cl11394
    Location:12 → 446
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  4. NM_010794.3 → NP_034924.3  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_034924.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants encode the same isoform.
    Source sequence(s)
    AI118268, AK040121, AL606829, BY088342
    Consensus CDS
    CCDS24602.1
    UniProtKB/Swiss-Prot
    P27808
    UniProtKB/TrEMBL
    Q544F0, Q8CIC9
    Related
    ENSMUSP00000080484.7, ENSMUST00000081794.7
    Conserved Domains (1) summary
    cl11394
    Location:12 → 446
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    49135018..49153854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314314.1 → XP_017169803.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P27808
    UniProtKB/TrEMBL
    Q544F0, Q8CIC9
    Conserved Domains (1) summary
    cl11394
    Location:12 → 446
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. XM_030245629.1 → XP_030101489.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P27808
    UniProtKB/TrEMBL
    Q544F0, Q8CIC9
    Conserved Domains (1) summary
    cl11394
    Location:12 → 446
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  3. XM_036156375.1 → XP_036012268.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P27808
    UniProtKB/TrEMBL
    Q544F0, Q8CIC9
    Conserved Domains (1) summary
    cl11394
    Location:12 → 446
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  4. XM_006532398.5 → XP_006532461.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006532461.1

    UniProtKB/Swiss-Prot
    P27808
    UniProtKB/TrEMBL
    Q544F0, Q8CIC9
    Conserved Domains (1) summary
    cl11394
    Location:12 → 446
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  5. XM_030245630.2 → XP_030101490.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P27808
    UniProtKB/TrEMBL
    Q544F0, Q8CIC9
    Conserved Domains (1) summary
    cl11394
    Location:12 → 446
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  6. XM_006532400.5 → XP_006532463.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006532463.1

    UniProtKB/Swiss-Prot
    P27808
    UniProtKB/TrEMBL
    Q544F0, Q8CIC9
    Conserved Domains (1) summary
    cl11394
    Location:12 → 446
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  7. XM_036156376.1 → XP_036012269.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P27808
    UniProtKB/TrEMBL
    Q544F0, Q8CIC9
    Conserved Domains (1) summary
    cl11394
    Location:12 → 446
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  8. XM_006532399.3 → XP_006532462.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006532462.1

    UniProtKB/Swiss-Prot
    P27808
    UniProtKB/TrEMBL
    Q544F0, Q8CIC9
    Conserved Domains (1) summary
    cl11394
    Location:12 → 446
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27808.1 GenPept UniProtKB/Swiss-Prot:P27808

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