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strl-1 START domain-containing protein;Steroidogenic acute regulatory-like protein 1 [ Caenorhabditis elegans ]

Gene ID: 172846, updated on 25-Apr-2024

Summary

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Gene symbol
strl-1
Gene description
START domain-containing protein;Steroidogenic acute regulatory-like protein 1
Primary source
WormBase:WBGene00009940
Locus tag
CELE_F52F12.7
See related
AllianceGenome:WB:WBGene00009940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lipid binding activity. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human STAR (steroidogenic acute regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (9928993..9930885)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene Methyltranfer_dom domain-containing protein Neighboring gene BAR domain-containing protein Neighboring gene MRG domain-containing protein Neighboring gene Dysbindin protein homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BPA interferes with StAR-mediated mitochondrial cholesterol transport to induce germline dysfunctions. Chen Y, et al. Reprod Toxicol, 2019 Dec. PMID 31445225, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in vesicle tethering to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
colocalizes_with endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-endosome membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
START domain-containing protein;Steroidogenic acute regulatory-like protein 1
NP_001251250.1
  • Confirmed by transcript evidence
NP_001251251.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9928993..9930885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001264321.3 → NP_001251250.1  Steroidogenic acute regulatory-like protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251250.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17883
    Conserved Domains (1) summary
    pfam01852
    Location:52 → 255
    START; START domain

  2. NM_001264322.2 → NP_001251251.1  START domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251251.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F5GUI0
    Conserved Domains (1) summary
    pfam01852
    Location:34 → 237
    START; START domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17883.2

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