hsp-70 Heat shock protein 70 [Caenorhabditis elegans] - Gene

Summary

Gene symbol: hsp-70
Gene description: Heat shock protein 70
Primary source: WormBase:WBGene00002026
Locus tag: CELE_C12C8.1
See related: AllianceGenome:WB:WBGene00002026
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Involved in determination of adult lifespan and response to heat. Part of chaperonin-containing T-complex. Is expressed in anal depressor muscle; mu_int_L; and mu_int_R. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; systemic lupus erythematosus; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1B (heat shock protein family A (Hsp70) member 1B); and HSPA6 (heat shock protein family A (Hsp70) member 6). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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The HSP110/HSP70 disaggregation system generates spreading-competent toxic alpha-synuclein species.
Title: The HSP110/HSP70 disaggregation system generates spreading-competent toxic α-synuclein species.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	HEP more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chaperonin-containing T-complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_492485.1

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The following sections contain reference sequences that belong to a specific genome build. Explain