Mef2d myocyte enhancer factor 2D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mef2dprovided by MGI
Official Full Name: myocyte enhancer factor 2Dprovided by MGI
Primary source: MGI:MGI:99533
See related: Ensembl:ENSMUSG00000001419 AllianceGenome:MGI:99533
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein dimerization activity. Acts upstream of or within several processes, including osteoblast differentiation; skeletal muscle cell differentiation; and skeletal system development. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; dorsal aorta; early conceptus; embryo mesenchyme; and genitourinary system. Orthologous to human MEF2D (myocyte enhancer factor 2D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 72.5), ovary adult (RPKM 42.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.78 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (88049248..88079398)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (88141941..88172091)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PGC-1alpha and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle.
Title: PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle.
Sevoflurane activates MEF2D-mediated Wnt/beta-catenin signaling pathway via microRNA-374b-5p to affect renal ischemia/reperfusion injury.
Title: Sevoflurane activates MEF2D-mediated Wnt/β-catenin signaling pathway via microRNA-374b-5p to affect renal ischemia/reperfusion injury.
A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.
Title: A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.
A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells.
Title: A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells.
MEF2D upregulation protects neurons from oxygen-glucose deprivation/re-oxygenation-induced injury by enhancing Nrf2 activation.
Title: MEF2D upregulation protects neurons from oxygen-glucose deprivation/re-oxygenation-induced injury by enhancing Nrf2 activation.
Loss of myocyte enhancer factor 2 expression in osteoclasts leads to opposing skeletal phenotypes.
Title: Loss of myocyte enhancer factor 2 expression in osteoclasts leads to opposing skeletal phenotypes.
Loss of Mef2D function enhances TLR induced IL-10 production in macrophages.
Title: Loss of Mef2D function enhances TLR induced IL-10 production in macrophages.
MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity.
Title: MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity.
Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors.
Title: Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors.
PP2A-B55delta as the first protein phosphatase to be involved in myoblast fusion and suggest that reversible phosphorylation of HDAC4 may coordinate differentiation and fusion events during myogenesis.
Title: Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mef2d (e-PCR), detects polymorphism
- UniSTS:238138

RH124803 (e-PCR)
- UniSTS:161625

Mef2d (e-PCR), detects polymorphism
- UniSTS:265605

Mef2d (e-PCR), detects polymorphism
- UniSTS:265606

RH126964 (e-PCR)
- UniSTS:207523

D1S262E (e-PCR)
- UniSTS:147387

NoName (e-PCR)
- UniSTS:234724

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chondrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endochondral ossification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myocyte-specific enhancer factor 2D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310587.2 → NP_001297516.1 myocyte-specific enhancer factor 2D isoform 1

See identical proteins and their annotated locations for NP_001297516.1

Status: VALIDATED

Source sequence(s)

AC137525

Consensus CDS

CCDS79939.1

UniProtKB/Swiss-Prot

E9QKS9, Q63943, Q63944

UniProtKB/TrEMBL

Q3URR2

Related

ENSMUSP00000103184.3, ENSMUST00000107559.3

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:97 → 151

HJURP_C; Holliday junction regulator protein family C-terminal repeat
NM_001310593.2 → NP_001297522.1 myocyte-specific enhancer factor 2D isoform 3

Status: VALIDATED

Source sequence(s)

AC137525

Consensus CDS

CCDS79940.1

UniProtKB/TrEMBL

E9QKT0, Q3URR2

Related

ENSMUSP00000103183.3, ENSMUST00000107558.9

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:96 → 150

HJURP_C; Holliday junction regulator protein family C-terminal repeat
NM_001410077.1 → NP_001397006.1 myocyte-specific enhancer factor 2D isoform 1

Status: VALIDATED

Source sequence(s)

AC137525

UniProtKB/Swiss-Prot

E9QKS9, Q63943, Q63944
NM_001410078.1 → NP_001397007.1 myocyte-specific enhancer factor 2D isoform 1

Status: VALIDATED

Source sequence(s)

AC137525

UniProtKB/Swiss-Prot

E9QKS9, Q63943, Q63944
NM_001410079.1 → NP_001397008.1 myocyte-specific enhancer factor 2D isoform 4

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410080.1 → NP_001397009.1 myocyte-specific enhancer factor 2D isoform 4

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410081.1 → NP_001397010.1 myocyte-specific enhancer factor 2D isoform 4

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410082.1 → NP_001397011.1 myocyte-specific enhancer factor 2D isoform 4

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410083.1 → NP_001397012.1 myocyte-specific enhancer factor 2D isoform 4

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410084.1 → NP_001397013.1 myocyte-specific enhancer factor 2D isoform 5

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410085.1 → NP_001397014.1 myocyte-specific enhancer factor 2D isoform 2

Status: VALIDATED

Source sequence(s)

AC137525

UniProtKB/TrEMBL

Q921S6
NM_001410086.1 → NP_001397015.1 myocyte-specific enhancer factor 2D isoform 3

Status: VALIDATED

Source sequence(s)

AC137525

UniProtKB/TrEMBL

E9Q5E0

Related

ENSMUSP00000113638.2, ENSMUST00000119251.8
NM_001410087.1 → NP_001397016.1 myocyte-specific enhancer factor 2D isoform 3

Status: VALIDATED

Source sequence(s)

AC137525

UniProtKB/TrEMBL

E9Q5E0
NM_001410088.1 → NP_001397017.1 myocyte-specific enhancer factor 2D isoform 6

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410089.1 → NP_001397018.1 myocyte-specific enhancer factor 2D isoform 7

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410090.1 → NP_001397019.1 myocyte-specific enhancer factor 2D isoform 8

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410091.1 → NP_001397020.1 myocyte-specific enhancer factor 2D isoform 9

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410092.1 → NP_001397021.1 myocyte-specific enhancer factor 2D isoform 9

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410093.1 → NP_001397022.1 myocyte-specific enhancer factor 2D isoform 10

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410094.1 → NP_001397023.1 myocyte-specific enhancer factor 2D isoform 11

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410095.1 → NP_001397024.1 myocyte-specific enhancer factor 2D isoform 12

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410096.1 → NP_001397025.1 myocyte-specific enhancer factor 2D isoform 12

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410097.1 → NP_001397026.1 myocyte-specific enhancer factor 2D isoform 12

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410098.1 → NP_001397027.1 myocyte-specific enhancer factor 2D isoform 13

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410099.1 → NP_001397028.1 myocyte-specific enhancer factor 2D isoform 13

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410100.1 → NP_001397029.1 myocyte-specific enhancer factor 2D isoform 13

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410101.1 → NP_001397030.1 myocyte-specific enhancer factor 2D isoform 14

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410102.1 → NP_001397031.1 myocyte-specific enhancer factor 2D isoform 14

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410103.1 → NP_001397032.1 myocyte-specific enhancer factor 2D isoform 15

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410104.1 → NP_001397033.1 myocyte-specific enhancer factor 2D isoform 15

Status: VALIDATED

Source sequence(s)

AC137525
NM_001410105.1 → NP_001397034.1 myocyte-specific enhancer factor 2D isoform 16

Status: VALIDATED

Source sequence(s)

AC137525
NM_133665.5 → NP_598426.1 myocyte-specific enhancer factor 2D isoform 2

See identical proteins and their annotated locations for NP_598426.1

Status: VALIDATED

Source sequence(s)

AC137525

Consensus CDS

CCDS38479.1

UniProtKB/TrEMBL

Q3URR2, Q921S6

Related

ENSMUSP00000001455.7, ENSMUST00000001455.13

Conserved Domains (3) summary

COG5068
Location:1 → 346

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:97 → 151

HJURP_C; Holliday junction regulator protein family C-terminal repeat

RNA

NR_176939.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC137525
NR_176940.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC137525
NR_176941.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC137525

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

88049248..88079398

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319472.2 → XP_017174961.1 myocyte-specific enhancer factor 2D isoform X1

UniProtKB/Swiss-Prot

E9QKS9, Q63943, Q63944

UniProtKB/TrEMBL

Q3URR2

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:97 → 151

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_011240034.3 → XP_011238336.1 myocyte-specific enhancer factor 2D isoform X7

Conserved Domains (3) summary

PHA03247
Location:126 → 257

PHA03247; large tegument protein UL36; Provisional

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:97 → 151

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_011240032.3 → XP_011238334.1 myocyte-specific enhancer factor 2D isoform X3

See identical proteins and their annotated locations for XP_011238334.1

UniProtKB/TrEMBL

Q3URR2, Q921S6

Conserved Domains (3) summary

COG5068
Location:1 → 346

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:97 → 151

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_030252450.2 → XP_030108310.1 myocyte-specific enhancer factor 2D isoform X1

UniProtKB/Swiss-Prot

E9QKS9, Q63943, Q63944

UniProtKB/TrEMBL

Q3URR2

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:97 → 151

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_006501090.4 → XP_006501153.1 myocyte-specific enhancer factor 2D isoform X2

UniProtKB/TrEMBL

Q3URR2

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:96 → 150

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_017319473.2 → XP_017174962.1 myocyte-specific enhancer factor 2D isoform X4

UniProtKB/TrEMBL

E9QKT0, Q3URR2

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:96 → 150

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_011240033.3 → XP_011238335.1 myocyte-specific enhancer factor 2D isoform X5

UniProtKB/TrEMBL

Q3URR2

Conserved Domains (2) summary

COG5068
Location:1 → 156

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...