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Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 [ Mus musculus (house mouse) ]

Gene ID: 17254, updated on 21-Apr-2024

Summary

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Official Symbol
Slc3a2provided by MGI
Official Full Name
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2provided by MGI
Primary source
MGI:MGI:96955
See related
Ensembl:ENSMUSG00000010095 AllianceGenome:MGI:96955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4F2; Cd98; Ly10; Mdu1; 4F2HC; Ly-10; NACAE; Ly-m10; Mgp-2hc
Summary
Predicted to enable amino acid transmembrane transporter activity and double-stranded RNA binding activity. Predicted to be involved in carboxylic acid transport and viral entry into host cell. Predicted to act upstream of or within response to exogenous dsRNA. Located in apical pole of neuron. Is active in synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and spinal cord. Orthologous to human SLC3A2 (solute carrier family 3 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 55.8), genital fat pad adult (RPKM 41.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 5.44 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8684931..8700733, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8706882..8723369, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9830166K06 gene Neighboring gene cholinergic receptor, muscarinic 1, CNS Neighboring gene STARR-positive B cell enhancer ABC_E8737 Neighboring gene STARR-positive B cell enhancer ABC_E9454 Neighboring gene STARR-positive B cell enhancer ABC_E1210 Neighboring gene predicted gene, 25855 Neighboring gene predicted gene, 25894 Neighboring gene small nucleolar RNA host gene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway. Boulter E, et al. Nat Commun, 2018 Nov 19. PMID 30451822, Free PMC Article
  2. Endothelial Cells Require CD98 for Efficient Angiogenesis-Brief Report. Liao Z, et al. Arterioscler Thromb Vasc Biol, 2016 Nov. PMID 27687603, Free PMC Article
  3. Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability. de la Ballina LR, et al. J Biol Chem, 2016 Apr 29. PMID 26945935, Free PMC Article
  4. Impaired CD98 signaling protects against graft-versus-host disease by increasing regulatory T cells. Nishio Y, et al. Transpl Immunol, 2016 Mar. PMID 26836475
  5. CD98 is a potential target for ablating B cell clonal expansion and autoantibody in multiple sclerosis. Cantor JM. J Neuroimmunol, 2014 Sep 15. PMID 25002078, Free PMC Article

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation.
    Title: Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation.
  2. Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE[-/-]mice.
    Title: Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE(-/-)mice.
  3. Screening of ferroptosis-related genes in sepsis-induced liver failure and analysis of immune correlation.
    Title: Screening of ferroptosis-related genes in sepsis-induced liver failure and analysis of immune correlation.
  4. Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's Disease.
    Title: Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's Disease.
  5. SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation.
    Title: SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation.
  6. Galectin-3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling.
    Title: Galectin-3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling.
  7. CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis.
    Title: CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis.
  8. SLC3A2 inhibits ferroptosis in laryngeal carcinoma via mTOR pathway.
    Title: SLC3A2 inhibits ferroptosis in laryngeal carcinoma via mTOR pathway.
  9. Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2.
    Title: Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2.
  10. Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice.
    Title: Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-alanine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-alanine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-leucine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-leucine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables aromatic amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aromatic amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables exogenous protein binding ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid secondary active transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-alanine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-alanine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in L-histidine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-leucine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-leucine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in L-leucine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-leucine transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in methionine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in phenylalanine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylalanine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in proline transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in symbiont entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone transport ISO
Inferred from Sequence Orthology
more info
  
involved_in tryptophan transport ISO
Inferred from Sequence Orthology
more info
  
involved_in tyrosine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in valine transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of amino acid transport complex ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apical pole of neuron IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
amino acid transporter heavy chain SLC3A2
Names
4F2 cell-surface antigen heavy chain
CD98 antigen
CD98 heavy chain
antigen identified by monoclonal antibodies 4F2
solute carrier family 3 member 2
type II transmembrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161413.2 → NP_001154885.1  amino acid transporter heavy chain SLC3A2 isoform a

    See identical proteins and their annotated locations for NP_001154885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (a).
    Source sequence(s)
    AC025794
    Consensus CDS
    CCDS50381.1
    UniProtKB/TrEMBL
    Q3TN39
    Related
    ENSMUSP00000130194.2, ENSMUST00000170157.8
    Conserved Domains (3) summary
    COG0366
    Location:169 → 513
    AmyA; Glycosidase [Carbohydrate transport and metabolism]
    pfam16028
    Location:85 → 156
    SLC3A2_N; Solute carrier family 3 member 2 N-terminus
    cl07893
    Location:139 → 468
    AmyAc_family; Alpha amylase catalytic domain family

  2. NM_001410771.1 → NP_001397700.1  amino acid transporter heavy chain SLC3A2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC025794
    UniProtKB/Swiss-Prot
    G3UWA6, P10852, Q54AH5

  3. NM_008577.5 → NP_032603.3  amino acid transporter heavy chain SLC3A2 isoform b

    See identical proteins and their annotated locations for NP_032603.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' coding region and 5' UTR, compared to variant 1. This results in a shorter and distinct N-terminus in isoform b, compared to isoform a.
    Source sequence(s)
    AC025794
    Consensus CDS
    CCDS29540.1
    UniProtKB/Swiss-Prot
    G3UWA6, P10852, Q54AH5
    UniProtKB/TrEMBL
    Q3TN39
    Related
    ENSMUSP00000010239.5, ENSMUST00000010239.6
    Conserved Domains (2) summary
    pfam16028
    Location:45 → 118
    SLC3A2_N; Solute carrier family 3 member 2 N-terminus
    cl38930
    Location:100 → 429
    AmyAc_family; Alpha amylase catalytic domain family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8684931..8700733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318078.3 → XP_017173567.1  amino acid transporter heavy chain SLC3A2 isoform X1

    UniProtKB/Swiss-Prot
    G3UWA6, P10852, Q54AH5
    UniProtKB/TrEMBL
    Q3TN39
    Conserved Domains (2) summary
    pfam16028
    Location:45 → 118
    SLC3A2_N; Solute carrier family 3 member 2 N-terminus
    cl38930
    Location:100 → 429
    AmyAc_family; Alpha amylase catalytic domain family

  2. XM_006526733.4 → XP_006526796.1  amino acid transporter heavy chain SLC3A2 isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPK4
    Related
    ENSMUSP00000146016.2, ENSMUST00000206598.2
    Conserved Domains (2) summary
    TIGR02403
    Location:179 → 297
    trehalose_treC; alpha,alpha-phosphotrehalase
    cl38930
    Location:1 → 206
    AmyAc_family; Alpha amylase catalytic domain family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10852.1 GenPept UniProtKB/Swiss-Prot:P10852

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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