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Abcc1 ATP-binding cassette, sub-family C member 1 [ Mus musculus (house mouse) ]

Gene ID: 17250, updated on 9-Dec-2024

Summary

Official Symbol
Abcc1provided by MGI
Official Full Name
ATP-binding cassette, sub-family C member 1provided by MGI
Primary source
MGI:MGI:102676
See related
Ensembl:ENSMUSG00000023088 AllianceGenome:MGI:102676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRP; Mrp1; Mdrap; Abcc1a; Abcc1b
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 11.9), genital fat pad adult (RPKM 10.8) and 27 other tissues See more
Orthologs
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Genomic context

See Abcc1 in Genome Data Viewer
Location:
16 A1; 16 9.75 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (14179317..14292743)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (14361453..14474878)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 11, smooth muscle Neighboring gene STARR-seq mESC enhancer starr_40179 Neighboring gene centrosomal protein 20 Neighboring gene STARR-seq mESC enhancer starr_40180 Neighboring gene STARR-seq mESC enhancer starr_40183 Neighboring gene predicted gene, 23116 Neighboring gene RIKEN cDNA A630010A05 gene Neighboring gene STARR-seq mESC enhancer starr_40186 Neighboring gene STARR-seq mESC enhancer starr_40188 Neighboring gene predicted gene, 57629

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type glutathione S-conjugate transporter activity PubMed 
enables ABC-type transporter activity  
enables ABC-type transporter activity  
enables ABC-type vitamin B12 transporter activity PubMed 
enables ABC-type vitamin B12 transporter activity  
enables ABC-type xenobiotic transporter activity  
enables ABC-type xenobiotic transporter activity  
enables ABC-type xenobiotic transporter activity  
enables ATP binding  
enables ATP hydrolysis activity  
enables ATPase-coupled lipid transmembrane transporter activity  
enables ATPase-coupled lipid transmembrane transporter activity  
enables amide transmembrane transporter activity  
enables carboxylic acid transmembrane transporter activity  
enables efflux transmembrane transporter activity PubMed 
enables efflux transmembrane transporter activity  
enables glutathione transmembrane transporter activity  
enables glutathione transmembrane transporter activity PubMed 
enables glutathione transmembrane transporter activity  
enables long-chain fatty acid transmembrane transporter activity  
enables long-chain fatty acid transmembrane transporter activity  
enables xenobiotic transmembrane transporter activity PubMed 
enables xenobiotic transmembrane transporter activity  
enables xenobiotic transmembrane transporter activity  
Items 1 - 25 of 43
Process Evidence Code Pubs
involved_in astrocyte differentiation  
involved_in astrocyte differentiation  
involved_in carboxylic acid transmembrane transport  
involved_in cell chemotaxis  
involved_in cell chemotaxis  
involved_in cellular response to amyloid-beta PubMed 
involved_in cobalamin transport PubMed 
involved_in cyclic nucleotide transport PubMed 
involved_in cyclic nucleotide transport  
involved_in export across plasma membrane PubMed 
involved_in export across plasma membrane  
involved_in glial cell differentiation  
involved_in glutathione transmembrane transport  
involved_in glutathione transmembrane transport  
involved_in glutathione transmembrane transport  
involved_in leukotriene transport PubMed 
involved_in long-chain fatty acid import across plasma membrane  
involved_in long-chain fatty acid import across plasma membrane  
involved_in phospholipid efflux  
involved_in phospholipid efflux  
involved_in phospholipid translocation  
involved_in phospholipid translocation  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell migration  
involved_in positive regulation of inflammatory response PubMed 
involved_in regulation of cellular response to drug  
involved_in regulation of cellular response to drug  
involved_in response to oxidative stress  
involved_in response to oxidative stress  
involved_in response to xenobiotic stimulus PubMed 
involved_in response to xenobiotic stimulus  
involved_in sphingolipid translocation  
involved_in sphingolipid translocation  
involved_in transepithelial transport  
involved_in transepithelial transport  
involved_in transmembrane transport  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane  
involved_in xenobiotic transport  
involved_in xenobiotic transport PubMed 
involved_in xenobiotic transport  
involved_in xenobiotic transport across blood-brain barrier  
involved_in xenobiotic transport across blood-brain barrier  
Items 1 - 25 of 43
Component Evidence Code Pubs
located_in apical plasma membrane  
located_in apical plasma membrane  
is_active_in basal plasma membrane PubMed 
located_in basal plasma membrane  
is_active_in basolateral plasma membrane  
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
located_in lateral plasma membrane  
located_in lateral plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  

General protein information

Preferred Names
multidrug resistance-associated protein 1
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1a
ATP-binding cassette, sub-family C (CFTR/MRP), member 1b
LTC4 transporter
glutathione-S-conjugate-translocating ATPase ABCC1
leukotriene C(4) transporter
multiple drug resistance-associated protein
NP_001412107.1
NP_032602.1
XP_017172377.1
XP_036015706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425178.1NP_001412107.1  multidrug resistance-associated protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154265
  2. NM_008576.4NP_032602.1  multidrug resistance-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_032602.1

    Status: VALIDATED

    Source sequence(s)
    AC154265
    Consensus CDS
    CCDS37264.1
    UniProtKB/Swiss-Prot
    O35379
    UniProtKB/TrEMBL
    A5D6P3
    Related
    ENSMUSP00000097743.4, ENSMUST00000100167.10
    Conserved Domains (1) summary
    TIGR00957
    Location:71527
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RNA

  1. NR_189144.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154265

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    14179317..14292743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316888.2XP_017172377.1  multidrug resistance-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    Q3UDM1
    Related
    ENSMUSP00000116714.2, ENSMUST00000130671.8
    Conserved Domains (1) summary
    TIGR00957
    Location:7773
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  2. XM_036159813.1XP_036015706.1  multidrug resistance-associated protein 1 isoform X3

    UniProtKB/TrEMBL
    Q8C7V6
    Conserved Domains (1) summary
    TIGR00957
    Location:1787
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
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