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Mdfi MyoD family inhibitor [ Mus musculus (house mouse) ]

Gene ID: 17240, updated on 5-Mar-2024

Summary

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Official Symbol
Mdfiprovided by MGI
Official Full Name
MyoD family inhibitorprovided by MGI
Primary source
MGI:MGI:107687
See related
Ensembl:ENSMUSG00000032717 AllianceGenome:MGI:107687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
I-mf; I-mfa
Summary
Enables DNA-binding transcription factor binding activity. Involved in several processes, including dorsal/ventral axis specification; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Acts upstream of or within embryonic skeletal system morphogenesis and trophoblast giant cell differentiation. Located in nucleus. Is expressed in medulla oblongata basal plate mantle layer; placenta; sensory organ; skeleton; and trophectoderm. Orthologous to human MDFI (MyoD family inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 46.3), ovary adult (RPKM 39.9) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 C; 17 23.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48126253..48145616, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47815328..47834691, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10960 Neighboring gene STARR-positive B cell enhancer ABC_E5617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47876786-47876895 Neighboring gene progastricsin (pepsinogen C) Neighboring gene transcription factor EB Neighboring gene STARR-positive B cell enhancer ABC_E2491 Neighboring gene STARR-positive B cell enhancer ABC_E5618 Neighboring gene STARR-seq mESC enhancer starr_42729 Neighboring gene predicted gene, 25201 Neighboring gene nuclear encoded rRNA 5S 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The inhibitor of MyoD Family A (I-MFA) regulates megakaryocyte lineage commitment and terminal differentiation. Houser JS, et al. Blood Cells Mol Dis, 2023 Sep. PMID 37267696
  2. Inhibitor of myogenic differentiation family isoform a, a new positive regulator of fibronectin production by glomerular mesangial cells. Shotorbani PY, et al. Am J Physiol Renal Physiol, 2020 Mar 1. PMID 31984795, Free PMC Article
  3. A TRPC1 protein-dependent pathway regulates osteoclast formation and function. Ong EC, et al. J Biol Chem, 2013 Aug 2. PMID 23770672, Free PMC Article
  4. Beta-catenin relieves I-mfa-mediated suppression of LEF-1 in mammalian cells. Pan W, et al. J Cell Sci, 2006 Dec 1. PMID 17090604
  5. The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse chromosome 17. Kraut N. Mamm Genome, 1997 Aug. PMID 9250874

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The inhibitor of MyoD Family A (I-MFA) regulates megakaryocyte lineage commitment and terminal differentiation.
    Title: The inhibitor of MyoD Family A (I-MFA) regulates megakaryocyte lineage commitment and terminal differentiation.
  2. These results suggest that I-mfa, increased by high glucose/diabetes through the production of reactive oxygen species, stimulates fibronectin production by mesangial cells.
    Title: Inhibitor of myogenic differentiation family isoform a, a new positive regulator of fibronectin production by glomerular mesangial cells.
  3. I-mfa functions as a molecular switch to suppress the store dependence of TRPC1
    Title: Inhibitor of myogenic family, a novel suppressor of store-operated currents through an interaction with TRPC1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within trophoblast giant cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myoD family inhibitor
Names
myogenic repressor I-mf

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109973.2 → NP_001103443.1  myoD family inhibitor isoform 1

    See identical proteins and their annotated locations for NP_001103443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AA048074, AA049446, AC113536, AI325040, AV360686, BY097762, CX564914, W65565
    Consensus CDS
    CCDS50134.1
    UniProtKB/Swiss-Prot
    P70331
    Related
    ENSMUSP00000069915.7, ENSMUST00000066368.13
    Conserved Domains (1) summary
    pfam15316
    Location:87 → 246
    MDFI; MyoD family inhibitor

  2. NM_001276390.1 → NP_001263319.1  myoD family inhibitor isoform 1

    See identical proteins and their annotated locations for NP_001263319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon structure and differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AA049446, AC113536, AI325040, BQ832230, CX564914, W54345, W65565
    Consensus CDS
    CCDS50134.1
    UniProtKB/Swiss-Prot
    P70331
    Conserved Domains (1) summary
    pfam15316
    Location:87 → 246
    MDFI; MyoD family inhibitor

  3. NM_001276391.1 → NP_001263320.1  myoD family inhibitor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001263320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' exon structure, differs in the 5' UTR, contains an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 2. It encodes isoform 2 which is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA049446, AC113536, AI325040, CX564914, W54345, W65565
    Conserved Domains (1) summary
    pfam15316
    Location:73 → 250
    MDFI; MyoD family inhibitor

  4. NM_010783.3 → NP_034913.2  myoD family inhibitor isoform 1

    See identical proteins and their annotated locations for NP_034913.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate 5' exon structure and differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AA049446, AC113536, AI325040, CX564914, W54345, W65565
    Consensus CDS
    CCDS50134.1
    UniProtKB/Swiss-Prot
    P70331
    Related
    ENSMUSP00000037888.8, ENSMUST00000035375.14
    Conserved Domains (1) summary
    pfam15316
    Location:87 → 246
    MDFI; MyoD family inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48126253..48145616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523742.2 → XP_006523805.2  myoD family inhibitor isoform X1

    See identical proteins and their annotated locations for XP_006523805.2

    Conserved Domains (1) summary
    pfam15316
    Location:73 → 250
    MDFI; MyoD family inhibitor

  2. XM_006523744.5 → XP_006523807.1  myoD family inhibitor isoform X2

    See identical proteins and their annotated locations for XP_006523807.1

    UniProtKB/Swiss-Prot
    P70330, P70331, P70332, Q5XK64, Q99JM9
    Conserved Domains (1) summary
    pfam15316
    Location:68 → 158
    MDFI; MyoD family inhibitor

  3. XM_006523745.5 → XP_006523808.1  myoD family inhibitor isoform X2

    See identical proteins and their annotated locations for XP_006523808.1

    UniProtKB/Swiss-Prot
    P70330, P70331, P70332, Q5XK64, Q99JM9
    Conserved Domains (1) summary
    pfam15316
    Location:68 → 158
    MDFI; MyoD family inhibitor

  4. XM_006523743.5 → XP_006523806.1  myoD family inhibitor isoform X2

    See identical proteins and their annotated locations for XP_006523806.1

    UniProtKB/Swiss-Prot
    P70330, P70331, P70332, Q5XK64, Q99JM9
    Related
    ENSMUST00000140234.2
    Conserved Domains (1) summary
    pfam15316
    Location:68 → 158
    MDFI; MyoD family inhibitor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70331.1 GenPept UniProtKB/Swiss-Prot:P70331

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