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Mcm7 minichromosome maintenance complex component 7 [ Mus musculus (house mouse) ]

Gene ID: 17220, updated on 11-Apr-2024

Summary

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Official Symbol
Mcm7provided by MGI
Official Full Name
minichromosome maintenance complex component 7provided by MGI
Primary source
MGI:MGI:1298398
See related
Ensembl:ENSMUSG00000029730 AllianceGenome:MGI:1298398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mcmd7; mCDC47
Summary
Enables single-stranded DNA binding activity. Contributes to DNA helicase activity. Acts upstream of or within DNA unwinding involved in DNA replication; cell population proliferation; and cellular response to xenobiotic stimulus. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 73.1), liver E14.5 (RPKM 66.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 76.97 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138162845..138170675, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138164583..138172111, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 113 Neighboring gene STARR-positive B cell enhancer ABC_E4799 Neighboring gene STARR-positive B cell enhancer ABC_E9656 Neighboring gene COP9 signalosome subunit 6 Neighboring gene microRNA 106b Neighboring gene microRNA 25 Neighboring gene microRNA 93 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138612151-138612338 Neighboring gene STARR-positive B cell enhancer ABC_E1693 Neighboring gene STARR-positive B cell enhancer ABC_E1694 Neighboring gene adaptor-related protein complex AP-4, mu 1 Neighboring gene STARR-seq mESC enhancer starr_14665 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer. McCarthy S, et al. Mol Oncol, 2007 Sep. PMID 18521193, Free PMC Article
  2. Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis. Honeycutt KA, et al. Oncogene, 2006 Jul 6. PMID 16518415
  3. Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. Ortega MA, et al. Biol Reprod, 2012 Sep. PMID 22674395, Free PMC Article
  4. Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer. Brake T, et al. Cancer Res, 2003 Dec 1. PMID 14678972
  5. Sequence of mouse CDC47, a member of the minichromosome maintenance (Mcm) family involved in the DNA replication licensing system. Takizawa N, et al. Gene, 1995 Dec 29. PMID 8566808

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
    Title: Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
  2. cellular DNA replication factor MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by green tea catechins
    Title: Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer.
  3. DNA binding and helicase activities of Mcm4/6/7 are significantly stimulated by Cdt1
    Title: Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.
  4. Accumulation and dynamics of Mcm7 are described during oogenesis and the first embryonic cell cycle.
    Title: Accumulation and dynamics of proteins of the MCM family during mouse oogenesis and the first embryonic cell cycle.
  5. Substrate preference and helicase actions of mouse MCM4/6/7 helicase complexes.
    Title: DNA binding and helicase actions of mouse MCM4/6/7 helicase.
  6. role of subunits in DNA helicases activity
    Title: Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex.
  7. cyclin D1/CDK4 complexes play a direct role in altering an inhibitory RB.MCM7 complex possibly allowing for setting of the origin in preparation for DNA replication
    Title: The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding.
  8. MCM7 may be a highly informative biomarker for cervical cancer.
    Title: Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to DNA helicase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables single-stranded DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA unwinding involved in DNA replication IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in premeiotic DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CMG complex ISO
Inferred from Sequence Orthology
more info
  
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MCM complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
DNA replication licensing factor MCM7
Names
CDC47 homolog
mini chromosome maintenance deficient 7
minichromosome maintenance deficient 7
NP_001343505.1
NP_001343506.1
NP_032594.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356576.1 → NP_001343505.1  DNA replication licensing factor MCM7 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC151719
    UniProtKB/TrEMBL
    Q3V122
    Conserved Domains (1) summary
    smart00350
    Location:38 → 534
    MCM; minichromosome maintenance proteins

  2. NM_001356577.1 → NP_001343506.1  DNA replication licensing factor MCM7 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC151719
    UniProtKB/TrEMBL
    Q3V122
    Conserved Domains (1) summary
    smart00350
    Location:38 → 534
    MCM; minichromosome maintenance proteins

  3. NM_008568.3 → NP_032594.1  DNA replication licensing factor MCM7 isoform a

    See identical proteins and their annotated locations for NP_032594.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC151719, AK133091
    Consensus CDS
    CCDS19793.1
    UniProtKB/Swiss-Prot
    Q61881
    UniProtKB/TrEMBL
    Q3U4T8, Q3UDI8, Q3V122
    Related
    ENSMUSP00000000505.10, ENSMUST00000000505.16
    Conserved Domains (3) summary
    smart00350
    Location:145 → 641
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:12 → 165
    MCM_N; MCM N-terminal domain
    cl21455
    Location:376 → 515
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    138162845..138170675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001784632.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61881.1 GenPept UniProtKB/Swiss-Prot:Q61881

Gene LinkOut

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