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Mcm6 minichromosome maintenance complex component 6 [ Mus musculus (house mouse) ]

Gene ID: 17219, updated on 5-Mar-2024

Summary

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Official Symbol
Mcm6provided by MGI
Official Full Name
minichromosome maintenance complex component 6provided by MGI
Primary source
MGI:MGI:1298227
See related
Ensembl:ENSMUSG00000026355 AllianceGenome:MGI:1298227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mcmd6; ASP-l1; D1Wsu22e
Summary
Enables single-stranded DNA binding activity. Contributes to DNA helicase activity. Acts upstream of or within DNA unwinding involved in DNA replication. Located in nucleus. Is expressed in several structures, including brain; eye; future brain; genitourinary system; and limb. Orthologous to human MCM6 (minichromosome maintenance complex component 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 53.6), liver E14.5 (RPKM 45.3) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Mcm6 in Genome Data Viewer
Location:
1 E3; 1 55.8 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (128259312..128287442, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (128331575..128359705, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41949 Neighboring gene UBX domain protein 4 Neighboring gene lactase Neighboring gene STARR-positive B cell enhancer ABC_E7743 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130255918-130256027 Neighboring gene STARR-positive B cell enhancer ABC_E2006 Neighboring gene STARR-positive B cell enhancer ABC_E8774 Neighboring gene STARR-positive B cell enhancer mm9_chr1:130268768-130269068 Neighboring gene aspartyl-tRNA synthetase 1 Neighboring gene STARR-seq mESC enhancer starr_02162 Neighboring gene STARR-seq mESC enhancer starr_02163 Neighboring gene STARR-positive B cell enhancer ABC_E1229 Neighboring gene predicted gene, 23902

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Accumulation and dynamics of proteins of the MCM family during mouse oogenesis and the first embryonic cell cycle. Swiech L, et al. Int J Dev Biol, 2007. PMID 17554680
  2. Structural basis for inhibition of the replication licensing factor Cdt1 by geminin. Lee C, et al. Nature, 2004 Aug 19. PMID 15286659
  3. Mouse MCM proteins: complex formation and transportation to the nucleus. Kimura H, et al. Genes Cells, 1996 Nov. PMID 9077461
  4. Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex. Kundu LR, et al. Nucleic Acids Res, 2010 Sep. PMID 20421204, Free PMC Article
  5. Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity. You Z, et al. J Biol Chem, 2008 Sep 5. PMID 18606811, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells.
    Title: UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells.
  2. DNA binding and helicase activities of Mcm4/6/7 are significantly stimulated by Cdt1
    Title: Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.
  3. Accumulation and dynamics of Mcm6 are described during oogenesis and the first embryonic cell cycle.
    Title: Accumulation and dynamics of proteins of the MCM family during mouse oogenesis and the first embryonic cell cycle.
  4. Substrate preference and helicase actions of mouse MCM4/6/7 helicase complexes.
    Title: DNA binding and helicase actions of mouse MCM4/6/7 helicase.
  5. role of subunits in dna helicase activity
    Title: Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to DNA helicase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to single-stranded 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to single-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables single-stranded DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA unwinding involved in DNA replication IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in premeiotic DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of CMG complex ISO
Inferred from Sequence Orthology
more info
  
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MCM complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
DNA replication licensing factor MCM6
Names
mini chromosome maintenance deficient 6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
NP_001300624.1
NP_032593.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313695.1 → NP_001300624.1  DNA replication licensing factor MCM6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate segment in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK078126, AK145520, BE447550, BY073760, CX202118
    Consensus CDS
    CCDS83586.1
    UniProtKB/TrEMBL
    Q3UC10, Q3ULG5
    Related
    ENSMUSP00000140308.2, ENSMUST00000190495.2
    Conserved Domains (3) summary
    smart00350
    Location:119 → 657
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:29 → 139
    MCM_N; MCM N-terminal domain
    cl21455
    Location:447 → 534
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_008567.2 → NP_032593.1  DNA replication licensing factor MCM6 isoform 1

    See identical proteins and their annotated locations for NP_032593.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK146770, BE447550, BY073760
    Consensus CDS
    CCDS15252.1
    UniProtKB/Swiss-Prot
    P97311, Q80YQ7
    UniProtKB/TrEMBL
    Q3UC10, Q542I2
    Related
    ENSMUSP00000027601.5, ENSMUST00000027601.11
    Conserved Domains (3) summary
    smart00350
    Location:119 → 657
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:29 → 139
    MCM_N; MCM N-terminal domain
    cl21455
    Location:447 → 534
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    128259312..128287442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97311.1 GenPept UniProtKB/Swiss-Prot:P97311

Gene LinkOut

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