U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mcm5 minichromosome maintenance complex component 5 [ Mus musculus (house mouse) ]

Gene ID: 17218, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Mcm5provided by MGI
Official Full Name
minichromosome maintenance complex component 5provided by MGI
Primary source
MGI:MGI:103197
See related
Ensembl:ENSMUSG00000005410 AllianceGenome:MGI:103197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdc46; Mcmd5; P1-CDC46
Summary
The protein encoded by this gene is a member of the oligameric minichromosome maintenance protein complex. During DNA replication, the complex loads onto chromatin in early G1 and is converted into an active replicative helicase during S phase. It functions to limit DNA synthesis to once per cell cycle. During embryogenesis, the encoded protein is negatively regulated through expression of paired box protein Pax 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Broad expression in liver E14.5 (RPKM 77.8), liver E14 (RPKM 74.7) and 18 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8 C1; 8 35.59 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (75836096..75855067)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (75109468..75128439)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21925 Neighboring gene STARR-seq mESC enhancer starr_21926 Neighboring gene STARR-positive B cell enhancer ABC_E8248 Neighboring gene dpy-30 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E244 Neighboring gene heme oxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_21928 Neighboring gene RASD family, member 2 Neighboring gene STARR-seq mESC enhancer starr_21930 Neighboring gene STARR-seq mESC enhancer starr_21931 Neighboring gene predicted gene 9644

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sox10 regulates skin melanocyte proliferation by activating the DNA replication licensing factor MCM5. Su Z, et al. J Dermatol Sci, 2017 Mar. PMID 27955842
  2. The structure and function of MCM from archaeal M. Thermoautotrophicum. Fletcher RJ, et al. Nat Struct Biol, 2003 Mar. PMID 12548282
  3. Reduced expression of pax-3 is associated with overexpression of cdc46 in the mouse embryo. Hill AL, et al. Dev Genes Evol, 1998 May. PMID 9601985
  4. Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: physical interaction between P1(MCM3) and CDC46 proteins. Kimura H, et al. Nucleic Acids Res, 1995 Jun 25. PMID 7610039, Free PMC Article
  5. Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity. De Arras L, et al. Genetics, 2014 Jun. PMID 24361939, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SOX10 directly activates MCM5 transcription by binding to conserved SOX10 consensus DNA sequences in the MCM5 promoter.
    Title: Sox10 regulates skin melanocyte proliferation by activating the DNA replication licensing factor MCM5.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in premeiotic DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of CMG complex ISO
Inferred from Sequence Orthology
more info
  
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
DNA replication licensing factor MCM5
Names
CDC46 homolog
mini chromosome maintenance deficient 5
minichromosome maintenance deficient 5, cell division cycle 46
NP_001289469.1
NP_032592.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302540.1 → NP_001289469.1  DNA replication licensing factor MCM5

    See identical proteins and their annotated locations for NP_001289469.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC084823, AK051795, BY576039, CJ075220
    Consensus CDS
    CCDS22424.1
    UniProtKB/Swiss-Prot
    P49718, Q52KC3
    UniProtKB/TrEMBL
    Q8BQ03
    Related
    ENSMUSP00000148648.2, ENSMUST00000212426.2
    Conserved Domains (3) summary
    smart00350
    Location:133 → 649
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:35 → 130
    MCM_N; MCM N-terminal domain
    NF033441
    Location:618 → 730
    BREX_BrxC; BREX system P-loop protein BrxC

  2. NM_008566.3 → NP_032592.2  DNA replication licensing factor MCM5

    See identical proteins and their annotated locations for NP_032592.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC084823, AK033196, CJ075220
    Consensus CDS
    CCDS22424.1
    UniProtKB/Swiss-Prot
    P49718, Q52KC3
    UniProtKB/TrEMBL
    Q8BQ03
    Related
    ENSMUSP00000126135.2, ENSMUST00000164309.3
    Conserved Domains (3) summary
    smart00350
    Location:133 → 649
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:35 → 130
    MCM_N; MCM N-terminal domain
    NF033441
    Location:618 → 730
    BREX_BrxC; BREX system P-loop protein BrxC

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    75836096..75855067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001778410.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49718.2 GenPept UniProtKB/Swiss-Prot:P49718

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous