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prp-31 U4/U6 small nuclear ribonucleoprotein Prp31 [ Caenorhabditis elegans ]

Gene ID: 172146, updated on 11-Apr-2024

Summary

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Gene symbol
prp-31
Gene description
U4/U6 small nuclear ribonucleoprotein Prp31
Primary source
WormBase:WBGene00022458
Locus tag
CELE_Y110A7A.8
See related
AllianceGenome:WB:WBGene00022458
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of U4 snRNP; precatalytic spliceosome; and spliceosomal tri-snRNP complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 11. Orthologous to human PRPF31 (pre-mRNA processing factor 31). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (5127828..5129611)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Elongator complex protein 1 Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Cell division cycle protein 27 homolog Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene 6-phosphofructo-2-kinase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
  2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  3. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal tri-snRNP complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U4 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
U4/U6 small nuclear ribonucleoprotein Prp31
NP_491527.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5127828..5129611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059126.6 → NP_491527.1  U4/U6 small nuclear ribonucleoprotein Prp31 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491527.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N592
    Conserved Domains (2) summary
    pfam01798
    Location:111 → 338
    Nop; snoRNA binding domain, fibrillarin
    pfam09785
    Location:346 → 475
    Prp31_C; Prp31 C terminal domain
Nucleotide Protein
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