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Mc4r melanocortin 4 receptor [ Mus musculus (house mouse) ]

Gene ID: 17202, updated on 31-Dec-2024

Summary

Official Symbol
Mc4rprovided by MGI
Official Full Name
melanocortin 4 receptorprovided by MGI
Primary source
MGI:MGI:99457
See related
Ensembl:ENSMUSG00000047259 AllianceGenome:MGI:99457
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkcp; Mc4-r
Summary
This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased cholesterol levels and insulin resistance. [provided by RefSeq, Dec 2012]
Orthologs
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Genomic context

See Mc4r in Genome Data Viewer
Location:
18 E1; 18 39.72 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (66990776..66993558, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (66857705..66860487, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41762 Neighboring gene predicted gene, 22219 Neighboring gene predicted gene, 30190 Neighboring gene STARR-seq mESC enhancer starr_44866 Neighboring gene STARR-seq mESC enhancer starr_44867 Neighboring gene STARR-seq mESC enhancer starr_44868 Neighboring gene predicted gene, 19784 Neighboring gene STARR-seq mESC enhancer starr_44869 Neighboring gene predicted gene, 57656

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone binding  
enables melanocortin receptor activity PubMed 
enables melanocortin receptor activity  
enables melanocyte-stimulating hormone receptor activity  
enables melanocyte-stimulating hormone receptor activity PubMed 
enables melanocyte-stimulating hormone receptor activity  
enables neuropeptide binding  
enables neuropeptide binding  
enables peptide hormone binding  
enables peptide hormone binding  
enables protein binding PubMed 
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in diet induced thermogenesis  
involved_in diet induced thermogenesis  
involved_in energy reserve metabolic process  
involved_in energy reserve metabolic process  
acts_upstream_of_or_within feeding behavior PubMed 
involved_in feeding behavior  
acts_upstream_of_or_within insulin secretion PubMed 
involved_in negative regulation of feeding behavior  
involved_in negative regulation of feeding behavior  
involved_in positive regulation of bone resorption PubMed 
involved_in positive regulation of bone resorption  
involved_in regulation of eating behavior PubMed 
involved_in regulation of feeding behavior  
involved_in regulation of grooming behavior  
involved_in regulation of grooming behavior  
involved_in regulation of metabolic process  
acts_upstream_of_or_within regulation of metabolic process PubMed 
involved_in response to bisphenol A  
acts_upstream_of_or_within response to food PubMed 
acts_upstream_of_or_within response to insulin PubMed 
involved_in response to melanocyte-stimulating hormone PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in plasma membrane  
located_in plasma membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016977.4NP_058673.2  melanocortin receptor 4

    See identical proteins and their annotated locations for NP_058673.2

    Status: REVIEWED

    Source sequence(s)
    AK136793, BB633776, BY646801
    Consensus CDS
    CCDS29316.1
    UniProtKB/Swiss-Prot
    P56450, Q49NR4, Q9EQM7
    UniProtKB/TrEMBL
    Q49NR1
    Related
    ENSMUSP00000054776.3, ENSMUST00000057942.4
    Conserved Domains (1) summary
    cd15353
    Location:45313
    7tmA_MC4R; melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    66990776..66993558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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