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Maz MYC-associated zinc finger protein (purine-binding transcription factor) [ Mus musculus (house mouse) ]

Gene ID: 17188, updated on 3-Apr-2024

Summary

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Official Symbol
Mazprovided by MGI
Official Full Name
MYC-associated zinc finger protein (purine-binding transcription factor)provided by MGI
Primary source
MGI:MGI:1338823
See related
Ensembl:ENSMUSG00000030678 AllianceGenome:MGI:1338823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MAZI; PUR1; Pur-1; SAF-1; SAF-2
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; hemolymphoid system; limb; nervous system; and retina. Orthologous to human MAZ (MYC associated zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 242.4), adrenal adult (RPKM 140.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 69.28 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126621306..126626177, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127021450..127027188, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2850 Neighboring gene PAXIP1 associated glutamate rich protein 1A Neighboring gene proline-rich transmembrane protein 2 Neighboring gene predicted gene, 53372 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134167876-134168063 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134170996-134171192 Neighboring gene STARR-seq mESC enhancer starr_20164 Neighboring gene kinesin family member 22 Neighboring gene STARR-positive B cell enhancer ABC_E9708 Neighboring gene zymogen granule protein 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural organization and expression of the mouse gene for Pur-1, a highly conserved homolog of the human MAZ gene. Song J, et al. Eur J Biochem, 1999 Feb. PMID 10092852
  2. CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters. Ortabozkoyun H, et al. Nat Genet, 2022 Feb. PMID 35145304, Free PMC Article
  3. Regulation of neural stem cell differentiation by transcription factors HNF4-1 and MAZ-1. Wang J, et al. Mol Neurobiol, 2013 Feb. PMID 22944911
  4. Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes. Himeda CL, et al. Mol Cell Biol, 2008 Oct. PMID 18710939, Free PMC Article
  5. Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heterologous cells. Kennedy GC, et al. Proc Natl Acad Sci U S A, 1992 Dec 1. PMID 1454839, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters.
    Title: CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters.
  2. The transcription factor Maz is essential for normal eye development.
    Title: The transcription factor Maz is essential for normal eye development.
  3. myc-associated zinc finger (MAZ) protein was essential for HIF2alpha activation of the Cav1 promoter.
    Title: Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation.
  4. HNF4-1 and MAZ-1 regulate the expression of Rho-GDIgamma and contribute to the differentiation of neural stem cells.
    Title: Regulation of neural stem cell differentiation by transcription factors HNF4-1 and MAZ-1.
  5. These data support a transcription mechanism for murine KRAS that involves MAZ, PARP-1 and duplex-quadruplex conformational changes in the promoter G-rich nuclease hypersensitive element.
    Title: The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element.
  6. These findings are consistent with a previously unrecognized role for MAZ in muscle gene regulation.
    Title: Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes.
  7. SAF-1 induces VEGF transcription by directly binding to its promoter; markedly higher levels of SAF-1 interaction with the VEGF promoter was detected in the cartilage tissues of arthritic mice as well as human osteoarthritic patients.
    Title: Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in termination of RNA polymerase II transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myc-associated zinc finger protein
Names
purine-binding transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372521.1 → NP_001359450.1  myc-associated zinc finger protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122863
    UniProtKB/Swiss-Prot
    P56671, Q9R1W0
    UniProtKB/TrEMBL
    A0A0U1RNL1
    Related
    ENSMUSP00000145610.2, ENSMUST00000206254.2
    Conserved Domains (3) summary
    COG5048
    Location:254 → 302
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:280 → 337
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:258 → 278
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001372522.1 → NP_001359451.1  myc-associated zinc finger protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122863
    Consensus CDS
    CCDS90332.1
    UniProtKB/Swiss-Prot
    P56671, Q9R1W0
    UniProtKB/TrEMBL
    A0A0U1RNL9
    Conserved Domains (2) summary
    COG5189
    Location:303 → 360
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001372523.1 → NP_001359452.1  myc-associated zinc finger protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122863
    Consensus CDS
    CCDS90332.1
    UniProtKB/Swiss-Prot
    P56671, Q9R1W0
    UniProtKB/TrEMBL
    A0A0U1RNL9
    Related
    ENSMUSP00000145619.2, ENSMUST00000205568.2
    Conserved Domains (2) summary
    COG5189
    Location:303 → 360
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001412678.1 → NP_001399607.1  myc-associated zinc finger protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122863

  5. NM_001412679.1 → NP_001399608.1  myc-associated zinc finger protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122863

  6. NM_001412680.1 → NP_001399609.1  myc-associated zinc finger protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122863

  7. NM_001412681.1 → NP_001399610.1  myc-associated zinc finger protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122863

  8. NM_010772.2 → NP_034902.1  myc-associated zinc finger protein isoform 1

    See identical proteins and their annotated locations for NP_034902.1

    Status: VALIDATED

    Source sequence(s)
    AC122863
    Consensus CDS
    CCDS40137.1
    UniProtKB/Swiss-Prot
    P56671, Q9R1W0
    UniProtKB/TrEMBL
    F8VPK3
    Related
    ENSMUSP00000032916.5, ENSMUST00000032916.6
    Conserved Domains (2) summary
    COG5189
    Location:303 → 360
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_164184.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122863

  2. NR_182025.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122863

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126621306..126626177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A47236 GenPept UniProt:A47236
P56671.1 GenPept UniProtKB/Swiss-Prot:P56671

Gene LinkOut

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