Maoa monoamine oxidase A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Maoaprovided by MGI
Official Full Name: monoamine oxidase Aprovided by MGI
Primary source: MGI:MGI:96915
See related: Ensembl:ENSMUSG00000025037 AllianceGenome:MGI:96915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110061B18Rik
Summary: Enables primary amine oxidase activity. Acts upstream of or within dopamine catabolic process and positive regulation of signal transduction. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Used to study Brunner Syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease; Brunner Syndrome; alcohol use disorder; autism spectrum disorder; and panic disorder. Orthologous to human MAOA (monoamine oxidase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in large intestine adult (RPKM 27.2), colon adult (RPKM 10.2) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.2; X 11.78 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (16485937..16554051)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (16619698..16687812)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of monoamine oxidase A in a prostate cancer model enhances anti-tumor immunity through reduced immune suppression.
Title: Deletion of monoamine oxidase A in a prostate cancer model enhances anti-tumor immunity through reduced immune suppression.
Antidepressant activity of Spathodea campanulata in mice and predictive affinity of spatheosides towards type A monoamine oxidase.
Title: Antidepressant activity of Spathodea campanulata in mice and predictive affinity of spatheosides towards type A monoamine oxidase.
Dual orexin receptor antagonist (DORA-12) treatment affects the overall levels of Net/maoA mRNA expression in the hippocampus.
Title: Dual orexin receptor antagonist (DORA-12) treatment affects the overall levels of Net/maoA mRNA expression in the hippocampus.
MAOA expression and enzyme activity was reduced in hypothalamus and increased in prefrontal cortex of prepubertally stressed hyper-aggressive male mice. Hypomethylation in prefrontal cortex and hypermethylation in hypothalamus of MAOA promoter negatively correlated with the expression pattern. Sirt1 binding to the MAOA promoter was increased in prefrontal cortex and reduced in hypothalamus. In females, MAO was unchanged.
Title: Brain region specific methylation and Sirt1 binding changes in MAOA promoter is associated with sexual dimorphism in early life stress induced aggressive behavior.
MAO inhibition prevented both mast cell degranulation and altered collagen deposition, thereby normalizing diastolic function. These results elucidate the mechanisms underlying MAO-induced damage in diabetic cardiomyopathy and provide novel evidence for the role of MAOs in inflammation and inter-organelle communication.
Title: Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes.
Reactive oxygen species produced by MAO-A lead to the accumulation of p53 in the cytosol where it inhibits parkin, an important regulator of mitophagy, resulting in mitochondrial dysfunction.
Title: Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy.
mice lacking both MAO isoforms, MAOA and MAOB, exhibit smaller prostate mass and develop epithelial atrophy in the ventral and dorsolateral prostates.
Title: Monoamine Oxidase Deficiency Causes Prostate Atrophy and Reduces Prostate Progenitor Cell Activity.
Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate
Title: Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate.
Study provides experimental evidence showing that sleep deprivation induces an increase in monoamine oxidase A levels in certain brain regions, such as the amygdala and hippocampus of mice that might mediate depressive-like behaviors.
Title: Paradoxical sleep deprivation modulates depressive-like behaviors by regulating the MAOA levels in the amygdala and hippocampus.
This study unravels a new link between MAO-dependent H2O2 production and lysosomal dysfunction. Altogether, our findings demonstrate that the MAO-A/H2O2 axis has a negative impact on the elimination and recycling of mitochondria through the autophagy-lysosome pathway, which participates in cardiomyocyte death and heart failure
Title: Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Transgenic (1) 1 citation
Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Maoa (e-PCR), detects polymorphism
- UniSTS:507040

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aliphatic amine oxidase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	ISO Inferred from Sequence Orthology more info
enables monoamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables primary amine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables primary amine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables primary amine oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables primary amine oxidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serotonin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within catecholamine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dopamine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phenylethylamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: amine oxidase [flavin-containing] A

Names: MAO-A; monoamine oxidase type A

NP_776101.3

EC 1.4.3.21

EC 1.4.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173740.3 → NP_776101.3 amine oxidase [flavin-containing] A

See identical proteins and their annotated locations for NP_776101.3

Status: VALIDATED

Source sequence(s)

AK146612, AK164457, BB694072

Consensus CDS

CCDS30033.1

UniProtKB/Swiss-Prot

B1AX52, Q64133, Q8K0Z8

UniProtKB/TrEMBL

Q3U2X5, Q3UJ53

Related

ENSMUSP00000026013.6, ENSMUST00000026013.6

Conserved Domains (2) summary

COG1231
Location:15 → 463

YobN; Monoamine oxidase [Amino acid transport and metabolism]

pfam13450
Location:18 → 84

NAD_binding_8; NAD(P)-binding Rossmann-like domain