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Man1a mannosidase 1, alpha [ Mus musculus (house mouse) ]

Gene ID: 17155, updated on 11-Apr-2024

Summary

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Official Symbol
Man1aprovided by MGI
Official Full Name
mannosidase 1, alphaprovided by MGI
Primary source
MGI:MGI:104677
See related
Ensembl:ENSMUSG00000003746 AllianceGenome:MGI:104677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PCR1; Man1a1
Summary
Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing; mannose trimming involved in glycoprotein ERAD pathway; and protein targeting to ER. Located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb mesenchyme; and sensory organ. Orthologous to human MAN1A1 (mannosidase alpha class 1A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 59.2), liver adult (RPKM 19.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B3; 10 27.4 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (53780881..53952712, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (53904785..54076616, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6844 Neighboring gene minichromosome maintenance 9 homologous recombination repair factor Neighboring gene STARR-positive B cell enhancer ABC_E10606 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:53349966-53350075 Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene family with sequence similarity 184, member A Neighboring gene STARR-positive B cell enhancer mm9_chr10:53704763-53705064 Neighboring gene STARR-positive B cell enhancer ABC_E6845 Neighboring gene STARR-positive B cell enhancer mm9_chr10:53735714-53736015 Neighboring gene predicted gene, 53584 Neighboring gene STARR-positive B cell enhancer mm9_chr10:53795485-53795786 Neighboring gene STARR-positive B cell enhancer ABC_E6848 Neighboring gene STARR-positive B cell enhancer ABC_E6849 Neighboring gene predicted gene, 16998 Neighboring gene STARR-seq mESC enhancer starr_26701 Neighboring gene predicted gene, 40651 Neighboring gene STARR-seq mESC enhancer starr_26702 Neighboring gene predicted gene, 26177

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Substrate recognition and catalysis by GH47 α-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway. Xiang Y, et al. Proc Natl Acad Sci U S A, 2016 Dec 6. PMID 27856750, Free PMC Article
  2. Differential expression and function of α-mannosidase I in stimulated naive and memory CD4+ T cells. Gebuhr I, et al. J Immunother, 2011 Jun. PMID 21577142
  3. Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases. Tempel W, et al. J Biol Chem, 2004 Jul 9. PMID 15102839
  4. Lysosomal alpha-mannosidases of mouse tissues: characteristics of the isoenzymes, and cloning and expression of a full-length cDNA. Beccari T, et al. Biochem J, 1997 Oct 1. PMID 9355733, Free PMC Article
  5. Isolation and expression of murine and rabbit cDNAs encoding an alpha 1,2-mannosidase involved in the processing of asparagine-linked oligosaccharides. Lal A, et al. J Biol Chem, 1994 Apr 1. PMID 8144580

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. in the bound substrate complex, hydrophobic stacking interactions between Trp residues and the glycan core anchor the base of the glycan structure to the enzyme cleft
    Title: Substrate recognition and catalysis by GH47 α-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway.
  2. Complex N-glycans generated by enzymes such as a-mannosidase I inhibit the activation of naive T cells.
    Title: Differential expression and function of α-mannosidase I in stimulated naive and memory CD4+ T cells.
  3. Data report the crystallization of murine Golgi mannosidase IA and the structural solution to 1.5-A resolution by molecular replacement
    Title: Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases.
  4. Downregulation of TOAG-1 and alpha-1,2-mannosidase expression occurred in graft infiltrating cells and expression of both genes was also downregulated after T-cell activation in vitro
    Title: Identification of gene markers for the prediction of allograft rejection or permanent acceptance.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mannose trimming involved in glycoprotein ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mannose trimming involved in glycoprotein ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to ER ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
Names
alpha-1,2-mannosidase IA
man(9)-alpha-mannosidase
man9-mannosidase
mannosidase alpha class 1A member 1
mannosyl-oligosaccharide alpha-1,2-mannosidase
processing alpha-1,2-mannosidase IA
NP_032574.1
XP_006512631.1
XP_006512632.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008548.5 → NP_032574.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

    See identical proteins and their annotated locations for NP_032574.1

    Status: VALIDATED

    Source sequence(s)
    AC153816, AC158642, AC164624
    Consensus CDS
    CCDS23848.1
    UniProtKB/Swiss-Prot
    P45700
    UniProtKB/TrEMBL
    A0A1W2P788, Q544T7
    Related
    ENSMUSP00000003843.9, ENSMUST00000003843.16
    Conserved Domains (2) summary
    pfam01532
    Location:204 → 642
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl39091
    Location:87 → 214
    SdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    53780881..53952712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512568.3 → XP_006512631.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1

    UniProtKB/TrEMBL
    A0A1W2P788
    Related
    ENSMUSP00000151568.2, ENSMUST00000220088.2
    Conserved Domains (2) summary
    pfam01532
    Location:295 → 733
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl39091
    Location:178 → 305
    SdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]

  2. XM_006512569.5 → XP_006512632.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X2

    See identical proteins and their annotated locations for XP_006512632.1

    UniProtKB/Swiss-Prot
    P45700
    UniProtKB/TrEMBL
    A0A1W2P788, Q544T7
    Related
    ENSMUSP00000101110.2, ENSMUST00000105470.9
    Conserved Domains (2) summary
    pfam01532
    Location:204 → 642
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl39091
    Location:87 → 214
    SdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]

RNA

  1. XR_001779471.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45700.1 GenPept UniProtKB/Swiss-Prot:P45700

Gene LinkOut

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