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Mfap2 microfibrillar-associated protein 2 [ Mus musculus (house mouse) ]

Gene ID: 17150, updated on 21-Apr-2024

Summary

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Official Symbol
Mfap2provided by MGI
Official Full Name
microfibrillar-associated protein 2provided by MGI
Primary source
MGI:MGI:99559
See related
Ensembl:ENSMUSG00000060572 AllianceGenome:MGI:99559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Magp; Magp1; MAGP-1; MFAP-2
Summary
Enables fibrinogen binding activity and fibronectin binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within platelet formation. Located in microfibril. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; genitourinary system; and lung. Orthologous to human MFAP2 (microfibril associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 107.3), ovary adult (RPKM 71.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 73.31 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140737735..140743284)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141010424..141015976)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11883 Neighboring gene STARR-positive B cell enhancer ABC_E10271 Neighboring gene succinate dehydrogenase complex, subunit B, iron sulfur (Ip) Neighboring gene STARR-positive B cell enhancer ABC_E6248 Neighboring gene ATPase type 13A2 Neighboring gene ciliary rootlet coiled-coil, rootletin Neighboring gene STARR-seq mESC enhancer starr_11885 Neighboring gene STARR-positive B cell enhancer ABC_E4695 Neighboring gene STARR-positive B cell enhancer ABC_E10272 Neighboring gene STARR-positive B cell enhancer ABC_E3532 Neighboring gene NECAP endocytosis associated 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Microfibril-Associated Protein 2 (MFAP2) Potentiates Invasion and Migration of Melanoma by EMT and Wnt/β-Catenin Pathway. Chen Z, et al. Med Sci Monit, 2020 May 28. PMID 32464633, Free PMC Article
  2. Contribution of metabolic disease to bone fragility in MAGP1-deficient mice. Turecamo SE, et al. Matrix Biol, 2018 Apr. PMID 29519758, Free PMC Article
  3. Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice. Walji TA, et al. Front Endocrinol (Lausanne), 2016. PMID 27445989, Free PMC Article
  4. Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling. Craft CS, et al. J Biol Chem, 2010 Jul 30. PMID 20501659, Free PMC Article
  5. Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems. Weinbaum JS, et al. J Biol Chem, 2008 Sep 12. PMID 18625713, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MFAP2 promotes HSCs activation through FBN1/TGF-beta/Smad3 pathway.
    Title: MFAP2 promotes HSCs activation through FBN1/TGF-β/Smad3 pathway.
  2. MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3.
    Title: MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3.
  3. Microfibril-Associated Protein 2 (MFAP2) Potentiates Invasion and Migration of Melanoma by EMT and Wnt/beta-Catenin Pathway.
    Title: Microfibril-Associated Protein 2 (MFAP2) Potentiates Invasion and Migration of Melanoma by EMT and Wnt/β-Catenin Pathway.
  4. Data implicate systemic metabolic dysfunction in the development of bone fragility in germline Mfap2(-/-) mice. Also, MAGP1 protein was detected in the Mfap2(Prx-/-) hematopoietic bone marrow, despite of its absence in osseous bone matrix and its transcript at both sites. This suggests MAGP1 from a secondary site may accumulate in the bone marrow, but not into the bone matrix, during times of regional MAGP1 depletion.
    Title: Contribution of metabolic disease to bone fragility in MAGP1-deficient mice.
  5. Findings indicate that the regulation of TGF-beta by MAGP1 is protective against the effects of metabolic stress, and its absence predisposes individuals to metabolic dysfunction.
    Title: The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-β.
  6. These studies provide support for increased RANKL expression associated with MAGP1 deficiency and provide a link to altered TGF-beta signaling as a possible causative signaling pathway regulating RANKL expression in MAGP1-deficient osteoblasts.
    Title: Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice.
  7. MAGP1 is a regulator of bone remodeling, and its absence results in osteopenia associated with an increase in osteoclast number
    Title: Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling.
  8. microfibril-associated glycoprotein-1 has a role in complex phenotypes in multiple organ systems
    Title: Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems.
  9. These findings show that MAGP1, a component of microfibrils and vascular elastic fibers, plays a role in hemostasis and thrombosis.
    Title: Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury.
  10. Site-directed and random mutagenesis demonstrated that a KLF sequence motif at -256/-270, an E-box at -222/-229, and a GC-box at -117/-125, are critical for the promoter function.
    Title: Regulatory elements of microfibril-associated glycoprotein-1 gene expression in muscle cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables fibrinogen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables fibronectin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryonic eye morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within platelet formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in microfibril IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microfibril IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microfibril ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microfibrillar-associated protein 2
Names
microfibril-associated glycoprotein 1
microfibril-associated glycoprotein 1A
microfibril-associated glycoprotein 1D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161799.3 → NP_001155271.2  microfibrillar-associated protein 2 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL645625
    Consensus CDS
    CCDS18860.2
    UniProtKB/Swiss-Prot
    P55002
    UniProtKB/TrEMBL
    Q99PM0
    Related
    ENSMUSP00000132711.4, ENSMUST00000166376.10
    Conserved Domains (1) summary
    pfam05507
    Location:91 → 151
    MAGP; Microfibril-associated glycoprotein (MAGP)

  2. NM_001369292.2 → NP_001356221.1  microfibrillar-associated protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL645625
    Conserved Domains (1) summary
    pfam05507
    Location:81 → 141
    MAGP; Microfibril-associated glycoprotein (MAGP)

  3. NM_001421243.2 → NP_001408172.2  microfibrillar-associated protein 2 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL645625
    UniProtKB/Swiss-Prot
    P55002

  4. NM_008546.5 → NP_032572.3  microfibrillar-associated protein 2 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL645625
    Consensus CDS
    CCDS18860.2
    UniProtKB/Swiss-Prot
    P55002
    UniProtKB/TrEMBL
    Q99PM0
    Related
    ENSMUSP00000071868.10, ENSMUST00000071977.10
    Conserved Domains (1) summary
    pfam05507
    Location:91 → 151
    MAGP; Microfibril-associated glycoprotein (MAGP)

RNA

  1. NR_161285.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL645625

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    140737735..140743284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538614.5 → XP_006538677.1  microfibrillar-associated protein 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55002.1 GenPept UniProtKB/Swiss-Prot:P55002

Gene LinkOut

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