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PDIA3P1 protein disulfide isomerase family A member 3 pseudogene 1 [ Homo sapiens (human) ]

Gene ID: 171423, updated on 19-Feb-2024

Summary

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Official Symbol
PDIA3P1provided by HGNC
Official Full Name
protein disulfide isomerase family A member 3 pseudogene 1provided by HGNC
Primary source
HGNC:HGNC:4607
See related
AllianceGenome:HGNC:4607
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERp60; GRP58P; PDIA3P
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Genomic context

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Location:
1q21.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (147177851..147179949)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (147628460..147630558, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (146649430..146651528)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NBPF member 13, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:146633127-146634326 Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1277 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1278 Neighboring gene chromodomain helicase DNA binding protein 1 like Neighboring gene flavin containing dimethylaniline monoxygenase 5 Neighboring gene chaperonin containing TCP1 subunit 8 pseudogene 1 Neighboring gene ribosomal protein L7a pseudogene 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PDIA3P1 promotes Temozolomide resistance in glioblastoma by inhibiting C/EBPβ degradation to facilitate proneural-to-mesenchymal transition. Gao Z, et al. J Exp Clin Cancer Res, 2022 Jul 15. PMID 35836243, Free PMC Article
  2. Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma. Wang S, et al. Cell Death Dis, 2020 Mar 3. PMID 32127518, Free PMC Article
  3. Pseudogene PDIA3P1 promotes cell proliferation, migration and invasion, and suppresses apoptosis in hepatocellular carcinoma by regulating the p53 pathway. Kong Y, et al. Cancer Lett, 2017 Oct 28. PMID 28823960
  4. Structures of the human gene for the protein disulfide isomerase-related polypeptide ERp60 and a processed gene and assignment of these genes to 15q15 and 1q21. Koivunen P, et al. Genomics, 1997 Jun 15. PMID 9205111

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A positive feedback between PDIA3P1 and OCT4 promotes the cancer stem cell properties of esophageal squamous cell carcinoma.
    Title: A positive feedback between PDIA3P1 and OCT4 promotes the cancer stem cell properties of esophageal squamous cell carcinoma.
  2. PDIA3P1 promotes Temozolomide resistance in glioblastoma by inhibiting C/EBPbeta degradation to facilitate proneural-to-mesenchymal transition.
    Title: PDIA3P1 promotes Temozolomide resistance in glioblastoma by inhibiting C/EBPβ degradation to facilitate proneural-to-mesenchymal transition.
  3. Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma.
    Title: Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma.
  4. our data suggest that PDIA3P1 acts as an oncogene in hepatocellular carcinoma and could be a potential prognostic marker and therapeutic target for hepatocellular carcinoma.
    Title: Pseudogene PDIA3P1 promotes cell proliferation, migration and invasion, and suppresses apoptosis in hepatocellular carcinoma by regulating the p53 pathway.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • ER-60 protein processed pseudogene
  • glucose regulated protein, 58kDa pseudogene
  • protein disulfide isomerase family A, member 3 pseudogene
  • protein disulfide isomerase-associated 3 pseudogene

Clone Names

  • FLJ53558

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_002305.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL356378

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    147177851..147179949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    147628460..147630558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_001327.1: Suppressed sequence

    Description
    NG_001327.1: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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