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Magea3 MAGE family member A3 [ Mus musculus (house mouse) ]

Gene ID: 17139, updated on 8-Feb-2024

Summary

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Official Symbol
Magea3provided by MGI
Official Full Name
MAGE family member A3provided by MGI
Primary source
MGI:MGI:1333832
See related
Ensembl:ENSMUSG00000094196 AllianceGenome:MGI:1333832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mage-a3
Summary
Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in testis. Orthologous to human MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 1.0) See more
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Genomic context

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Location:
X F3; X 72.38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (153731176..153742027, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (154948180..154959031, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene claudin 34B1 Neighboring gene MAGE family member A6 Neighboring gene transmembrane and tetratricopeptide repeat containing 3 pseudogene Neighboring gene predicted gene, 25257

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new family of mouse genes homologous to the human MAGE genes. De Plaen E, et al. Genomics, 1999 Jan 15. PMID 9933564
  2. An overview of the MAGE gene family with the identification of all human members of the family. Chomez P, et al. Cancer Res, 2001 Jul 15. PMID 11454705
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables caspase binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
melanoma antigen family A, 3
Names
melanoma antigen, family A, 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020017.2 → NP_064401.2  melanoma antigen family A, 3

    See identical proteins and their annotated locations for NP_064401.2

    Status: VALIDATED

    Source sequence(s)
    BC119064
    Consensus CDS
    CCDS30489.1
    UniProtKB/TrEMBL
    O89007, Q6T340
    Related
    ENSMUSP00000078793.5, ENSMUST00000079867.6
    Conserved Domains (2) summary
    pfam01454
    Location:134 → 271
    MAGE; MAGE family
    pfam12440
    Location:44 → 78
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    153731176..153742027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528721.1 → XP_006528784.1  melanoma antigen family A, 3 isoform X1

    See identical proteins and their annotated locations for XP_006528784.1

    UniProtKB/TrEMBL
    O89007, Q6T340
    Conserved Domains (2) summary
    pfam01454
    Location:134 → 271
    MAGE; MAGE family
    pfam12440
    Location:44 → 78
    MAGE_N; Melanoma associated antigen family N terminal

  2. XM_006528723.1 → XP_006528786.1  melanoma antigen family A, 3 isoform X1

    See identical proteins and their annotated locations for XP_006528786.1

    UniProtKB/TrEMBL
    O89007, Q6T340
    Conserved Domains (2) summary
    pfam01454
    Location:134 → 271
    MAGE; MAGE family
    pfam12440
    Location:44 → 78
    MAGE_N; Melanoma associated antigen family N terminal

  3. XM_006528722.1 → XP_006528785.1  melanoma antigen family A, 3 isoform X1

    See identical proteins and their annotated locations for XP_006528785.1

    UniProtKB/TrEMBL
    O89007, Q6T340
    Conserved Domains (2) summary
    pfam01454
    Location:134 → 271
    MAGE; MAGE family
    pfam12440
    Location:44 → 78
    MAGE_N; Melanoma associated antigen family N terminal

  4. XM_006528724.1 → XP_006528787.1  melanoma antigen family A, 3 isoform X1

    See identical proteins and their annotated locations for XP_006528787.1

    UniProtKB/TrEMBL
    O89007, Q6T340
    Conserved Domains (2) summary
    pfam01454
    Location:134 → 271
    MAGE; MAGE family
    pfam12440
    Location:44 → 78
    MAGE_N; Melanoma associated antigen family N terminal
Nucleotide Protein Strain
Heading Accession and Version

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