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Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) [ Mus musculus (house mouse) ]

Gene ID: 17133, updated on 9-Dec-2024

Summary

Official Symbol
Maffprovided by MGI
Official Full Name
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)provided by MGI
Primary source
MGI:MGI:96910
See related
Ensembl:ENSMUSG00000042622 AllianceGenome:MGI:96910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within in utero embryonic development; regulation of epidermal cell differentiation; and skeletal muscle cell differentiation. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human MAFF (MAF bZIP transcription factor F). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in small intestine adult (RPKM 12.2), duodenum adult (RPKM 12.0) and 23 other tissues See more
Orthologs
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Genomic context

See Maff in Genome Data Viewer
Location:
15 E1; 15 37.7 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79230813..79243278)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79346621..79359078)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group VI Neighboring gene predicted gene, 41358 Neighboring gene STARR-positive B cell enhancer ABC_E7389 Neighboring gene predicted gene 20420 Neighboring gene STARR-positive B cell enhancer ABC_E1913 Neighboring gene STARR-seq mESC enhancer starr_39174 Neighboring gene transmembrane protein 184b Neighboring gene microRNA 1943 Neighboring gene STARR-seq mESC enhancer starr_39180 Neighboring gene STARR-seq mESC enhancer starr_39181 Neighboring gene casein kinase 1, epsilon Neighboring gene predicted gene 16059

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex  
part_of RNA polymerase II transcription regulator complex  
located_in mitochondrion  
located_in mitochondrion  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  

General protein information

Preferred Names
transcription factor MafF
Names
V-maf musculoaponeurotic fibrosarcoma oncogene homolog F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304830.2NP_001291759.1  transcription factor MafF

    See identical proteins and their annotated locations for NP_001291759.1

    Status: VALIDATED

    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS27638.1
    UniProtKB/Swiss-Prot
    O54791
    UniProtKB/TrEMBL
    Q3U0G5, Q3UKW6
    Related
    ENSMUSP00000154850.2, ENSMUST00000229130.2
    Conserved Domains (1) summary
    cd14717
    Location:47115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
  2. NM_001304831.2NP_001291760.2  transcription factor MafF

    Status: VALIDATED

    Source sequence(s)
    AC165278
    UniProtKB/Swiss-Prot
    O54791
    UniProtKB/TrEMBL
    Q3U0G5, Q3UKW6
    Related
    ENSMUSP00000131628.2, ENSMUST00000163691.3
  3. NM_001304832.3NP_001291761.2  transcription factor MafF

    Status: VALIDATED

    Source sequence(s)
    AC165278
    UniProtKB/Swiss-Prot
    O54791
    UniProtKB/TrEMBL
    Q3U0G5, Q3UKW6
  4. NM_010755.5NP_034885.1  transcription factor MafF

    See identical proteins and their annotated locations for NP_034885.1

    Status: VALIDATED

    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS27638.1
    UniProtKB/Swiss-Prot
    O54791
    UniProtKB/TrEMBL
    Q3U0G5, Q3UKW6
    Related
    ENSMUSP00000094076.4, ENSMUST00000096350.11
    Conserved Domains (1) summary
    cd14717
    Location:47115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79230813..79243278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159212.1XP_036015105.1  transcription factor MafF isoform X1

    Conserved Domains (1) summary
    cd14717
    Location:158226
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
  2. XM_036159213.1XP_036015106.1  transcription factor MafF isoform X2

    UniProtKB/Swiss-Prot
    O54791
    UniProtKB/TrEMBL
    Q3U0G5, Q3UKW6
    Conserved Domains (1) summary
    cd14717
    Location:47115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
  3. XM_006520550.5XP_006520613.1  transcription factor MafF isoform X2

    See identical proteins and their annotated locations for XP_006520613.1

    UniProtKB/Swiss-Prot
    O54791
    UniProtKB/TrEMBL
    Q3U0G5, Q3UKW6
    Conserved Domains (1) summary
    cd14717
    Location:47115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
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