UBE2L5 ubiquitin conjugating enzyme E2 L5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: UBE2L5provided by HGNC
Official Full Name: ubiquitin conjugating enzyme E2 L5provided by HGNC
Primary source: HGNC:HGNC:13477
See related: Ensembl:ENSG00000236444 AllianceGenome:HGNC:13477
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: UBCH7N2; UBE2L5P
Summary: Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in protein K11-linked ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 13q12.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (30422493..30429758)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (29644906..29652176)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (30996630..31003895)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

ECD15824 (e-PCR)
- UniSTS:296839

ECD17907 (e-PCR)
- UniSTS:298919

REN2026 (e-PCR)
- UniSTS:326826

REN2027 (e-PCR)
- UniSTS:326827

REN2028 (e-PCR)
- UniSTS:326828

REN2029 (e-PCR)
- UniSTS:326829

REN2030 (e-PCR)
- UniSTS:326830

REN2031 (e-PCR)
- UniSTS:326831

REN2032 (e-PCR)
- UniSTS:326832

REN2033 (e-PCR)
- UniSTS:326833

REN2034 (e-PCR)
- UniSTS:326834

REN2035 (e-PCR)
- UniSTS:326835

REN2036 (e-PCR)
- UniSTS:326836

REN2037 (e-PCR)
- UniSTS:326837

REN2038 (e-PCR)
- UniSTS:326838

ECD12546 (e-PCR)
- UniSTS:293579

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein K11-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 L5

Names: ubiquitin-protein ligase L5

NP_001342176.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355247.2 → NP_001342176.1 ubiquitin-conjugating enzyme E2 L5

Status: VALIDATED

Source sequence(s)

AL161893

Consensus CDS

CCDS86346.1

UniProtKB/Swiss-Prot

A0A1B0GUS4

UniProtKB/TrEMBL

A8K4W8

Related

ENSP00000490225.1, ENST00000635918.2

Conserved Domains (1) summary

smart00212
Location:6 → 149

UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues