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Galnt10 polypeptide N-acetylgalactosaminyltransferase 10 [ Mus musculus (house mouse) ]

Gene ID: 171212, updated on 11-Apr-2024

Summary

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Official Symbol
Galnt10provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 10provided by MGI
Primary source
MGI:MGI:1890480
See related
Ensembl:ENSMUSG00000020520 AllianceGenome:MGI:1890480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Galnt9; GalNAc-T9; ppGaNTase; GalNAc-T10; C330012K04Rik
Summary
Enables polypeptide N-acetylgalactosaminyltransferase activity. Acts upstream of or within protein O-linked glycosylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; eye; integumental system; and limb. Orthologous to human GALNT10 (polypeptide N-acetylgalactosaminyltransferase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 25.4), large intestine adult (RPKM 14.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 35.27 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (57536268..57678327)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (57645442..57787514)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 114, member A2 Neighboring gene STARR-positive B cell enhancer ABC_E1825 Neighboring gene microfibrillar-associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_29572 Neighboring gene predicted gene, 51895 Neighboring gene RIKEN cDNA 4933424L21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:57458544-57458653 Neighboring gene predicted gene, 51896 Neighboring gene predicted gene, 46282 Neighboring gene STARR-seq mESC enhancer starr_29577 Neighboring gene predicted gene, 24582 Neighboring gene RIKEN cDNA 2010001A14 gene Neighboring gene STARR-positive B cell enhancer ABC_E5228 Neighboring gene predicted gene, 53707

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase mRNA exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain. Nelson PA, et al. Brain Res Gene Expr Patterns, 2002 Jan. PMID 15018805
  2. Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9. Ten Hagen KG, et al. J Biol Chem, 2001 May 18. PMID 11278534
  3. Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development. Kingsley PD, et al. Glycobiology, 2000 Dec. PMID 11159923
  4. Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function. Vincentz JW, et al. Circ Res, 2019 Aug 30. PMID 31366290, Free PMC Article
  5. Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans. Yoshida CA, et al. J Biol Chem, 2014 Sep 19. PMID 25107907, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GALNT10 exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain
    Title: A new UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase mRNA exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in O-glycan processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 10
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10
polypeptide GalNAc transferase 10
pp-GaNTase 10
protein-UDP acetylgalactosaminyltransferase 10
NP_598950.2
XP_006532454.1
XP_030101480.1
XP_030101481.1
XP_030101482.1
XP_036012265.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134189.2 → NP_598950.2  polypeptide N-acetylgalactosaminyltransferase 10

    See identical proteins and their annotated locations for NP_598950.2

    Status: VALIDATED

    Source sequence(s)
    AK033515, BB626609, BC060617
    Consensus CDS
    CCDS24719.1
    UniProtKB/Swiss-Prot
    Q6KAQ2, Q6P9S7, Q8BZU8, Q91YJ6
    UniProtKB/TrEMBL
    Q3TXV9, Q5SQF9
    Related
    ENSMUSP00000065096.8, ENSMUST00000066987.14
    Conserved Domains (4) summary
    cd02510
    Location:148 → 443
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:144 → 443
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:461 → 589
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:459 → 587
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    57536268..57678327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156372.1 → XP_036012265.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X2

    Conserved Domains (2) summary
    cd02510
    Location:1 → 244
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:260 → 388
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. XM_030245621.2 → XP_030101481.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X1

    UniProtKB/TrEMBL
    Q3TXV9
    Conserved Domains (2) summary
    cd02510
    Location:51 → 346
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:362 → 490
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  3. XM_030245620.2 → XP_030101480.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X1

    UniProtKB/TrEMBL
    Q3TXV9
    Conserved Domains (2) summary
    cd02510
    Location:51 → 346
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:362 → 490
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  4. XM_030245622.2 → XP_030101482.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X2

    Conserved Domains (2) summary
    cd02510
    Location:1 → 244
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:260 → 388
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  5. XM_006532391.4 → XP_006532454.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X1

    See identical proteins and their annotated locations for XP_006532454.1

    UniProtKB/TrEMBL
    Q3TXV9
    Conserved Domains (2) summary
    cd02510
    Location:51 → 346
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:362 → 490
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9S7.1 GenPept UniProtKB/Swiss-Prot:Q6P9S7

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