Ntng2 netrin G2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ntng2provided by MGI
Official Full Name: netrin G2provided by MGI
Primary source: MGI:MGI:2159341
See related: Ensembl:ENSMUSG00000035513 AllianceGenome:MGI:2159341
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lmnt2; 2610016D08Rik
Summary: The protein encoded by this gene belongs to a subclass of the netrin family called netrin-G proteins. Unlike classic netrins, which act as diffusible chemoattractants, netrin-Gs are glycosylphosphatidylinositol-anchored membrane proteins that interact with specific transmembrane proteins. In mouse, this gene is preferentially expressed in the cerebral cortex, habenular nucleus and superior colliculus. Knockout mutant mice display a lack of behavioral startle in response to acoustic stimuli. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression: Broad expression in adrenal adult (RPKM 73.1), ovary adult (RPKM 25.0) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 19.57 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (29084738..29138111, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (29194726..29248099, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pre-synaptic netrin-G1 and netrin-G2 diversify the complexity of vertebrate behaviors and differentially regulate post-synaptic properties.
Title: Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins.
netrin-G/NGL interactions differentially control synaptic plasticity in distinct circuits via retrograde signaling mechanisms
Title: Netrin-G/NGL complexes encode functional synaptic diversification.
The complementary expression patterns of Ntng1 and Ntng2 are determined by transcriptional cis-regulatory elements widely scattered in these loci.
Title: Identification of transcriptional regulatory elements for Ntng1 and Ntng2 genes in mice.
Mice in which netrin-G2 has been genetically inhibited do not startle to an acoustic stimulus, but otherwise perform normally through a behavioral test battery. There were no inner ear structural abnormalities.
Title: Netrin-G2 and netrin-G2 ligand are both required for normal auditory responsiveness.
Axonal Ntng2 transneuronally determines lamina-specific subdendritic segments.
Title: Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments.
selectively expressed in distinct neuronal subsets that include populations in forebrain, midbrain, hindbrain, spinal cord, and spinal ganglia
Title: Laminets: laminin- and netrin-related genes expressed in distinct neuronal subsets.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489272

PMC154335P1 (e-PCR)
- UniSTS:271305

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic specialization assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic specialization assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron projection arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: netrin-G2

Names: laminet 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305805.1 → NP_001292734.1 netrin-G2 isoform c precursor

See identical proteins and their annotated locations for NP_001292734.1

Status: REVIEWED

Description

Transcript Variant: This variant (c) lacks an in-frame exon in the 3' coding region compared to variant b. It encodes isoform c, which is shorter than isoform b.

Source sequence(s)

AB052338, AL772379, BC141258, BM934422

Consensus CDS

CCDS84499.1

UniProtKB/TrEMBL

J3QNA0

Related

ENSMUSP00000088688.3, ENSMUST00000091153.9

Conserved Domains (4) summary

cd00055
Location:286 → 332

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:444 → 491

Laminin_EGF; Laminin EGF domain

pfam00055
Location:60 → 285

Laminin_N; Laminin N-terminal (Domain VI)

pfam07974
Location:491 → 521

EGF_2; EGF-like domain
NM_133500.2 → NP_598007.1 netrin-G2 isoform a precursor

See identical proteins and their annotated locations for NP_598007.1

Status: REVIEWED

Description

Transcript Variant: This variant (a) lacks two in-frame exons in the 3' coding region compared to variant b. It encodes isoform a, which is shorter than isoform b.

Source sequence(s)

AB052336, AL772379, BC141258, BM934422

Consensus CDS

CCDS15851.1

UniProtKB/TrEMBL

A2AKW8, J3QNA0

Related

ENSMUSP00000099937.2, ENSMUST00000102873.8

Conserved Domains (4) summary

cd00055
Location:286 → 332

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:410 → 457

Laminin_EGF; Laminin EGF domain

pfam00055
Location:60 → 285

Laminin_N; Laminin N-terminal (Domain VI)

pfam07974
Location:457 → 487

EGF_2; EGF-like domain
NM_133501.2 → NP_598008.1 netrin-G2 isoform b precursor

See identical proteins and their annotated locations for NP_598008.1

Status: REVIEWED

Description

Transcript Variant: This variant (b) represents the longest transcript and encodes the longest isoform (b).

Source sequence(s)

AB052337, AL772379, BC141258, BM934422

Consensus CDS

CCDS15852.1

UniProtKB/Swiss-Prot

A2AKX0, Q8R4F1, Q8R4F2, Q8VIP6, Q8VIP7, Q8VIP8

UniProtKB/TrEMBL

J3QNA0

Related

ENSMUSP00000035468.3, ENSMUST00000048455.9

Conserved Domains (4) summary

cd00055
Location:286 → 332

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:469 → 516

Laminin_EGF; Laminin EGF domain

pfam00055
Location:60 → 285

Laminin_N; Laminin N-terminal (Domain VI)

pfam07974
Location:516 → 546

EGF_2; EGF-like domain