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Fut10 fucosyltransferase 10 [ Mus musculus (house mouse) ]

Gene ID: 171167, updated on 5-Mar-2024

Summary

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Official Symbol
Fut10provided by MGI
Official Full Name
fucosyltransferase 10provided by MGI
Primary source
MGI:MGI:2384748
See related
Ensembl:ENSMUSG00000046152 AllianceGenome:MGI:2384748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
fuc-TX; fut10A
Summary
Enables alpha-(1->3)-fucosyltransferase activity. Acts upstream of or within cerebral cortex radially oriented cell migration and neuronal stem cell population maintenance. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Is expressed in central nervous system and retina. Orthologous to human FUT10 (fucosyltransferase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 2.1), limb E14.5 (RPKM 2.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Fut10 in Genome Data Viewer
Location:
8 A3; 8 18.1 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (31677342..31757310)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (31187313..31265284)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E557 Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene TELO2 interacting protein 2 Neighboring gene MAK16 homolog Neighboring gene SUMO-conjugating enzyme UBC9 pseudogene Neighboring gene eukaryotic translation initiation factor 3, subunit H pseudogene Neighboring gene RIKEN cDNA 7420700N18 gene Neighboring gene discs, large homolog-associated protein 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9. Zhu M, et al. Aging (Albany NY), 2021 Jul 13. PMID 34257163, Free PMC Article
  2. The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations. Kumar A, et al. J Biol Chem, 2013 Oct 4. PMID 23986452, Free PMC Article
  3. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). Mollicone R, et al. J Biol Chem, 2009 Feb 13. PMID 19088067
  4. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. Roos C, et al. J Biol Chem, 2002 Feb 1. PMID 11698403
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9.
    Title: CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9.
  2. Fut10 is involved in a unique alpha1,3-fucosyltransferase activity with stringent substrate specificity.
    Title: The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC40819

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-(1->3)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-(1->3)-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-glycan fucosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebral cortex radially oriented cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuronal stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-(1,3)-fucosyltransferase 10
Names
fucosyltransferase X
galactoside 3-L-fucosyltransferase 10
NP_001012535.1
NP_001273351.1
NP_001273353.1
NP_001273354.1
NP_598922.1
XP_030099189.1
XP_036009676.1
XP_036009677.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012517.6 → NP_001012535.1  alpha-(1,3)-fucosyltransferase 10 isoform a

    See identical proteins and their annotated locations for NP_001012535.1

    Status: VALIDATED

    Source sequence(s)
    AC115775
    Consensus CDS
    CCDS22223.1
    UniProtKB/Swiss-Prot
    Q5F2L2, Q8C457, Q8K0S3, Q8R247
    Related
    ENSMUSP00000069816.6, ENSMUST00000066173.12
    Conserved Domains (2) summary
    pfam00852
    Location:219 → 354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:82 → 177
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  2. NM_001286422.2 → NP_001273351.1  alpha-(1,3)-fucosyltransferase 10 isoform a

    See identical proteins and their annotated locations for NP_001273351.1

    Status: VALIDATED

    Source sequence(s)
    AC115775
    Consensus CDS
    CCDS22223.1
    UniProtKB/Swiss-Prot
    Q5F2L2, Q8C457, Q8K0S3, Q8R247
    Related
    ENSMUSP00000125265.2, ENSMUST00000161502.2
    Conserved Domains (2) summary
    pfam00852
    Location:219 → 354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:82 → 177
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  3. NM_001286424.2 → NP_001273353.1  alpha-(1,3)-fucosyltransferase 10 isoform b

    See identical proteins and their annotated locations for NP_001273353.1

    Status: VALIDATED

    Source sequence(s)
    AC115775
    Consensus CDS
    CCDS52536.1
    UniProtKB/Swiss-Prot
    Q5F2L2
    Conserved Domains (2) summary
    pfam00852
    Location:219 → 354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:82 → 177
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  4. NM_001286425.2 → NP_001273354.1  alpha-(1,3)-fucosyltransferase 10 isoform c

    See identical proteins and their annotated locations for NP_001273354.1

    Status: VALIDATED

    Source sequence(s)
    AC115775
    Consensus CDS
    CCDS72111.1
    UniProtKB/Swiss-Prot
    Q5F2L2
    Related
    ENSMUSP00000106156.3, ENSMUST00000110527.9

  5. NM_134161.4 → NP_598922.1  alpha-(1,3)-fucosyltransferase 10 isoform b

    See identical proteins and their annotated locations for NP_598922.1

    Status: VALIDATED

    Source sequence(s)
    AC115775
    Consensus CDS
    CCDS52536.1
    UniProtKB/Swiss-Prot
    Q5F2L2
    Related
    ENSMUSP00000124437.2, ENSMUST00000161788.8
    Conserved Domains (2) summary
    pfam00852
    Location:219 → 354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:82 → 177
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    31677342..31757310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153783.1 → XP_036009676.1  alpha-(1,3)-fucosyltransferase 10 isoform X2

    Conserved Domains (1) summary
    pfam00852
    Location:1 → 120
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

  2. XM_030243329.2 → XP_030099189.1  alpha-(1,3)-fucosyltransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    Q5F2L2, Q8C457, Q8K0S3, Q8R247
    Conserved Domains (2) summary
    pfam00852
    Location:219 → 354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:82 → 177
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

  3. XM_036153784.1 → XP_036009677.1  alpha-(1,3)-fucosyltransferase 10 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5F2L2.1 GenPept UniProtKB/Swiss-Prot:Q5F2L2

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