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ZNF525 zinc finger protein 525 [ Homo sapiens (human) ]

Gene ID: 170958, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF525provided by HGNC
Official Full Name
zinc finger protein 525provided by HGNC
Primary source
HGNC:HGNC:29423
See related
Ensembl:ENSG00000203326 AllianceGenome:HGNC:29423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.8), prostate (RPKM 2.5) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF525 in Genome Data Viewer
Location:
19q13.42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53365705..53386590)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56445220..56466092)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53868958..53889843)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 6, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53836118-53836982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15065 Neighboring gene zinc finger protein 845 Neighboring gene putative zinc finger protein 137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53872557-53873058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53873059-53873558 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:53877455-53878025 Neighboring gene ZNF765-ZNF761 readthrough Neighboring gene ribosomal protein L39 pseudogene 35 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11009 Neighboring gene zinc finger protein 765 Neighboring gene putative zinc finger protein 137 Neighboring gene ribosomal protein L39 pseudogene 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. Nagase T, et al. DNA Res, 2001 Dec 31. PMID 11853319
  2. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett EJ, et al. Cell, 2010 Dec 10. PMID 21145461, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough ZNF765-ZNF761

Readthrough gene: ZNF765-ZNF761, Included gene: ZNF765, Included gene: ZNF761

Homology

Clone Names

  • KIAA1979

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 525

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348156.2 → NP_001335085.1  zinc finger protein 525 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010467, AC125388, AK097037, BQ028675, BX952742, DA790976
    Consensus CDS
    CCDS86802.1
    UniProtKB/Swiss-Prot
    J3KR51, Q8N782, Q8TF23
    Related
    ENSP00000417696.1, ENST00000474037.6
    Conserved Domains (3) summary
    COG5048
    Location:130 → 393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273 → 293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  2. NM_001348157.2 → NP_001335086.1  zinc finger protein 525 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an alternate exon in the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC010467, AC125388, BQ028675, DA790976, DB221179
    Consensus CDS
    CCDS86803.1
    UniProtKB/TrEMBL
    J3KR62
    Related
    ENSP00000419136.1, ENST00000467003.1
    Conserved Domains (5) summary
    COG5048
    Location:94 → 357
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:231 → 282
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:237 → 257
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:277 → 302
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:1 → 12
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

RNA

  1. NR_145445.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010467, AC125388, AK097037, BQ028675, BX952742, DA790976

  2. NR_145446.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5'exon, alternate internal exon, and uses an alternate splice site in the 3' exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC010467, AC125388, AK097037, BQ028675

  3. NR_145447.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 3' exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC125388, AK097037, BQ028675, DA790976
    Related
    ENST00000475179.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    53365705..53386590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    56445220..56466092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N782.3 GenPept UniProtKB/Swiss-Prot:Q8N782

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials
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