Abcb1a ATP binding cassette subfamily B member 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcb1aprovided by RGD
Official Full Name: ATP binding cassette subfamily B member 1Aprovided by RGD
Primary source: RGD:619951
See related: Ensembl:ENSRNOG00000008012 AllianceGenome:RGD:619951
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Abcb1; Mdr1a
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including cellular response to lipid; response to alkaloid; and response to amino acid. Located in apical plasma membrane and brush border membrane. Biomarker of several diseases, including end stage renal disease; epilepsy (multiple); human immunodeficiency virus infectious disease; non-alcoholic fatty liver disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 100.7), Kidney (RPKM 76.4) and 9 other tissues See more
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Genomic context

Location:: 4q12

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (26312403..26488456, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (25357467..25529941, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (22339829..22517642, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver.
Title: Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver.
Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.
Title: Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.
Effect of MicroRNA145 on the multidrug resistance gene of ulcerative colitis in rats.
Title: Effect of MicroRNA145 on the multidrug resistance gene of ulcerative colitis in rats.
Galactosemia caused the osmotic stress in lenses; it also markedly leads to the upregulations of aldose reductase, P-glycoprotein, and Clcn3 in lens epithelial cells, together resulting in obvious osmotic expansion in vitro and in vivo.
Title: Upregulations of Clcn3 and P-Gp Provoked by Lens Osmotic Expansion in Rat Galactosemic Cataract.
Abcb1a is critical in maintaining blood-testis barrier integrity, while Abcb1b is crucial for junction reassembly at the blood-testis barrier.
Title: Abcb1a and Abcb1b genes function differentially in blood-testis barrier dynamics in the rat.
The placenta and maternal/fetal intestine, brain, kidneys and liver were sampled and analysed for Abcb1a, Abcb1b and Abcg2 expression.
Title: Long-term administration of tenofovir or emtricitabine to pregnant rats; effect on Abcb1a, Abcb1b and Abcg2 expression in the placenta and in maternal and fetal organs.
Study demonstrates that P-GP expression and function may be altered in cerebral cortex, hippocampus, liver and kidney of rats under the vitamin A deficiency condition.
Title: The Alterations in the Expression and Function of P-Glycoprotein in Vitamin A-Deficient Rats as well as the Effect of Drug Disposition in Vivo.
The data indicate that Pgp and Bcrp do not play significant roles in drug distribution into peripheral nerve tissues in rats, while working in concert to regulate brain penetration.
Title: Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats.
Both relative liver and kidney weights were higher in Mdr1a (and Mrp2)knockout animals.
Title: Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics.
Report drug metabolizing phenotype of Mdr1a knockout rats.
Title: Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type xenobiotic transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables carboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ceramide floppase activity	ISO Inferred from Sequence Orthology more info
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables floppase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine floppase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine flippase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in carboxylic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic salinity response	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to alkaloid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to antibiotic	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to borneol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to external biotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mycotoxin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in ceramide translocation	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in daunorubicin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of blood-retinal barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in hormone transport	IDA Inferred from Direct Assay more info	PubMed
involved_in intestinal absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in maintenance of blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sensory perception of pain	IEP Inferred from Expression Pattern more info	PubMed
involved_in phospholipid translocation	ISO Inferred from Sequence Orthology more info
involved_in placenta development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of establishment of Sertoli cell barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of response to drug	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of response to drug	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to bicellular tight junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chloride transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of intestinal absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to antineoplastic agent	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to codeine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cyclosporin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucagon	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glycoside	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mycotoxin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to quercetin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to thyroxine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in terpenoid transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport across blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intercellular canaliculus	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP binding cassette subfamily B member 1A

Names: ATP binding cassette subfamily B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1A; ATP-binding cassette, subfamily B (MDR/TAP), member 1A; multiple drug resistant 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133401.2 → NP_596892.1 ATP binding cassette subfamily B member 1A

See identical proteins and their annotated locations for NP_596892.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A0G2KA64, A0A9K3Y745, Q6PSM0, Q9JK64

Related

ENSRNOP00000075278.2, ENSRNOT00000082359.2

Conserved Domains (3) summary

cd03249
Location:385 → 621

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:51 → 1259

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:54 → 335

ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

26312403..26488456 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235994.5 → XP_006236056.1 ATP binding cassette subfamily B member 1A isoform X1

See identical proteins and their annotated locations for XP_006236056.1

UniProtKB/TrEMBL

A0A0G2KA64, A0A9K3Y745, Q6PSM0, Q9JK64

Conserved Domains (3) summary

cd03249
Location:385 → 621

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:51 → 1259

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:54 → 335

ABC_membrane; ABC transporter transmembrane region
XM_063285445.1 → XP_063141515.1 ATP binding cassette subfamily B member 1A isoform X2