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Tmed1 transmembrane p24 trafficking protein 1 [ Mus musculus (house mouse) ]

Gene ID: 17083, updated on 5-Mar-2024

Summary

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Official Symbol
Tmed1provided by MGI
Official Full Name
transmembrane p24 trafficking protein 1provided by MGI
Primary source
MGI:MGI:106201
See related
Ensembl:ENSMUSG00000032180 AllianceGenome:MGI:106201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
St2l; Ly84l; Il1rl1l
Summary
Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to act upstream of or within protein transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human TMED1 (transmembrane p24 trafficking protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 31.6), limb E14.5 (RPKM 24.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmed1 in Genome Data Viewer
Location:
9 A3; 9 7.81 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21418676..21421530, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21507380..21510234, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dynamin 2 Neighboring gene predicted gene, 46104 Neighboring gene predicted gene, 57796 Neighboring gene microRNA 199a-1 Neighboring gene STARR-positive B cell enhancer ABC_E8279 Neighboring gene cDNA sequence AB124611 Neighboring gene STARR-positive B cell enhancer ABC_E11402 Neighboring gene STARR-positive B cell enhancer mm9_chr9:21350851-21351152 Neighboring gene coactivator-associated arginine methyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_23505 Neighboring gene predicted gene, 39303

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning of a putative ligand for the T1/ST2 receptor. Gayle MA, et al. J Biol Chem, 1996 Mar 8. PMID 8621446
  2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cargo receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane emp24 domain-containing protein 1
Names
interleukin 1 receptor-like 1 ligand
lymphocyte antigen 84 ligand
p24 family protein gamma-1
p24gamma1
putative T1/ST2 receptor-binding protein
transmembrane emp24 domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324510.1 → NP_001311439.1  transmembrane emp24 domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK133513, CB203970
    UniProtKB/Swiss-Prot
    Q3V009

  2. NM_010744.4 → NP_034874.2  transmembrane emp24 domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034874.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK133513, BC138498
    Consensus CDS
    CCDS22904.1
    UniProtKB/Swiss-Prot
    Q3TUX8, Q3V009, Q61073, Q91YK3
    UniProtKB/TrEMBL
    B2RRM5
    Related
    ENSMUSP00000034698.8, ENSMUST00000034698.9
    Conserved Domains (1) summary
    pfam01105
    Location:33 → 219
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RNA

  1. NR_136911.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK133513, AK160525, BC138498
    Related
    ENSMUST00000214285.2

  2. NR_136912.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA087804, AK133513, BC138498
    Related
    ENSMUST00000213316.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21418676..21421530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V009.1 GenPept UniProtKB/Swiss-Prot:Q3V009

Gene LinkOut

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