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Glmn glomulin, FKBP associated protein [ Mus musculus (house mouse) ]

Gene ID: 170823, updated on 5-Mar-2024

Summary

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Official Symbol
Glmnprovided by MGI
Official Full Name
glomulin, FKBP associated proteinprovided by MGI
Primary source
MGI:MGI:2141180
See related
Ensembl:ENSMUSG00000029276 AllianceGenome:MGI:2141180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fap48; Fap68; 9330160J16Rik
Summary
Predicted to enable hepatocyte growth factor receptor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase inhibitor activity. Acts upstream of or within circulatory system development and neural tube closure. Predicted to be part of Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; and Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including arterial system; respiratory system; skeleton; skin; and urinary system. Human ortholog(s) of this gene implicated in arteriovenous malformation and glomus tumor. Orthologous to human GLMN (glomulin, FKBP associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 4.4), CNS E18 (RPKM 3.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Glmn in Genome Data Viewer
Location:
5 F; 5 52.23 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107696828..107745754, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107548962..107597888, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene BTB domain containing 8 Neighboring gene predicted gene, 33885 Neighboring gene LSM12 homolog pseudogene Neighboring gene RIKEN cDNA 1700028K03 gene Neighboring gene STARR-seq mESC enhancer starr_13890 Neighboring gene STARR-positive B cell enhancer ABC_E1683 Neighboring gene RNA polymerase II associated protein 2 Neighboring gene RIKEN cDNA A930041C12 gene Neighboring gene Gfi1 +35 kb enhancer Neighboring gene RIKEN cDNA 4930428O21 gene Neighboring gene +19.5 kb enhancer downstream of Gfi1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. Suzuki S, et al. Proc Natl Acad Sci U S A, 2014 Oct 7. PMID 25246571, Free PMC Article
  2. Glomulin is predominantly expressed in vascular smooth muscle cells in the embryonic and adult mouse. McIntyre BA, et al. Gene Expr Patterns, 2004 May. PMID 15053987
  3. Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation. Suzuki S, et al. EMBO Rep, 2018 Jan. PMID 29191979, Free PMC Article
  4. Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Arai T, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904573, Free PMC Article
  5. Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. Rios JJ, et al. J Bone Miner Res, 2021 Aug. PMID 33905568, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Shigella hijacks the glomulin-cIAP1-cIAP2-inflammasome axis to promote inflammation.
    Title: Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation.
  2. Results indicate a bacterial adaptation that hijacks inflammasome activation via interactions between IpaH7.8 E3 ubiquitin ligase and glomulin (GLMN).
    Title: Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages.
  3. The glomulin expression during murine development (E9.5 days post-coitum until adulthood) by non-radioactive in situ hybridization was studied.
    Title: Glomulin is predominantly expressed in vascular smooth muscle cells in the embryonic and adult mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6885

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hepatocyte growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within circulatory system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epigenetic regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in vasculogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul4A-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of cullin-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glomulin
Names
FAP
FK506-binding protein-associated protein
FKBP-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161738.1 → NP_001155210.1  glomulin isoform a

    See identical proteins and their annotated locations for NP_001155210.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC134411, AK034160
    Consensus CDS
    CCDS19505.1
    UniProtKB/Swiss-Prot
    Q3TFR5, Q8BZM1, Q99LB8
    UniProtKB/TrEMBL
    Q3TMW7
    Related
    ENSMUSP00000080766.3, ENSMUST00000082121.9
    Conserved Domains (1) summary
    pfam08568
    Location:1 → 527
    Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

  2. NM_001161739.1 → NP_001155211.1  glomulin isoform b

    See identical proteins and their annotated locations for NP_001155211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AC117574, AC134411, AK169045
    Consensus CDS
    CCDS51587.1
    UniProtKB/TrEMBL
    Q3T9A5, Q3TMW7
    Related
    ENSMUSP00000098509.4, ENSMUST00000100949.10
    Conserved Domains (1) summary
    pfam08568
    Location:1 → 462
    Kinetochor_Ybp2; uncharacterized protein family, YAP/Alf4/glomulin

  3. NM_133248.2 → NP_573511.2  glomulin isoform a

    See identical proteins and their annotated locations for NP_573511.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC134411, AK169045, BY013339
    Consensus CDS
    CCDS19505.1
    UniProtKB/Swiss-Prot
    Q3TFR5, Q8BZM1, Q99LB8
    UniProtKB/TrEMBL
    Q3TMW7
    Related
    ENSMUSP00000077168.7, ENSMUST00000078021.13
    Conserved Domains (1) summary
    pfam08568
    Location:1 → 527
    Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    107696828..107745754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249410.3 → XP_011247712.1  glomulin isoform X2

    Conserved Domains (1) summary
    pfam08568
    Location:14 → 224
    Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

  2. XM_030254179.1 → XP_030110039.1  glomulin isoform X2

    Conserved Domains (1) summary
    pfam08568
    Location:14 → 224
    Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

  3. XM_006534800.5 → XP_006534863.1  glomulin isoform X1

    See identical proteins and their annotated locations for XP_006534863.1

    UniProtKB/Swiss-Prot
    Q3TFR5, Q8BZM1, Q99LB8
    UniProtKB/TrEMBL
    Q3TMW7
    Conserved Domains (1) summary
    pfam08568
    Location:1 → 527
    Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

  4. XM_017320694.3 → XP_017176183.1  glomulin isoform X2

    Conserved Domains (1) summary
    pfam08568
    Location:14 → 224
    Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin

RNA

  1. XR_001784631.2 RNA Sequence

    Related
    ENSMUST00000124546.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZM1.1 GenPept UniProtKB/Swiss-Prot:Q8BZM1

Gene LinkOut

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