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Il1rl1 interleukin 1 receptor-like 1 [ Mus musculus (house mouse) ]

Gene ID: 17082, updated on 16-Apr-2024

Summary

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Official Symbol
Il1rl1provided by MGI
Official Full Name
interleukin 1 receptor-like 1provided by MGI
Primary source
MGI:MGI:98427
See related
Ensembl:ENSMUSG00000026069 AllianceGenome:MGI:98427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1
Summary
Enables interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of T-helper 1 type immune response; positive regulation of macrophage activation; and regulation of cytokine production. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in external side of plasma membrane and extracellular matrix. Is expressed in several structures, including immune system; musculoskeletal system; salivary gland; skin; and visual system. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 1.3), liver E14 (RPKM 1.3) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Il1rl1 in Genome Data Viewer
Location:
1 B; 1 19.19 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40444105..40504575)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40404864..40465418)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor, type I Neighboring gene STARR-positive B cell enhancer ABC_E5749 Neighboring gene STARR-seq mESC enhancer starr_00738 Neighboring gene interleukin 1 receptor-like 2 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00741 Neighboring gene interleukin 18 receptor 1 Neighboring gene interleukin 18 receptor accessory protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway. Akimoto M, et al. Proc Natl Acad Sci U S A, 2023 May 2. PMID 37094129, Free PMC Article
  2. ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses. Topczewska PM, et al. Front Immunol, 2023. PMID 37063913, Free PMC Article
  3. ST2 and the alteration of cobalt, sodium, potassium and calcium concentration in acute inflammation. Stankovic MS, et al. Exp Mol Pathol, 2022 Oct. PMID 35908617
  4. A rapid and quantitative detection method for plasma soluble growth stimulating gene protein 2 based on time resolved fluorescence immunochromatography. Jing X, et al. Anal Methods, 2022 Jun 9. PMID 35608240
  5. IL-33/ST2 Axis Protects Against Traumatic Brain Injury Through Enhancing the Function of Regulatory T Cells. Xie D, et al. Front Immunol, 2022. PMID 35432343, Free PMC Article

See all (346) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis.
    Title: The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis.
  2. Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.
    Title: Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.
  3. Detrimental impact of the IL-33/ST2 axis in an animal infection model with Cryptococcus neoformans.
    Title: Detrimental impact of the IL-33/ST2 axis in an animal infection model with Cryptococcus neoformans.
  4. The Role of the IL-33/ST2 Axis in CpG-Induced Macrophage Activation Syndrome.
    Title: The Role of the IL-33/ST2 Axis in CpG-Induced Macrophage Activation Syndrome.
  5. THE IL-33/ST2 AXIS PROMOTES ACUTE RESPIRATORY DISTRESS SYNDROME BY NATURAL KILLER T CELLS.
    Title: THE IL-33/ST2 AXIS PROMOTES ACUTE RESPIRATORY DISTRESS SYNDROME BY NATURAL KILLER T CELLS.
  6. Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway.
    Title: Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway.
  7. ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses.
    Title: ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses.
  8. The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis.
    Title: The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis.
  9. A comparative study of IL-33 and its receptor ST2 in a C57BL/6 J mouse model of pulmonary Cryptococcus neoformans infection.
    Title: A comparative study of IL-33 and its receptor ST2 in a C57BL/6 J mouse model of pulmonary Cryptococcus neoformans infection.
  10. Setd2 supports GATA3[+]ST2[+] thymic-derived Treg cells and suppresses intestinal inflammation.
    Title: Setd2 supports GATA3(+)ST2(+) thymic-derived Treg cells and suppresses intestinal inflammation.
Submit: New GeneRIF Correction See all GeneRIFs (154)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (12) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-33 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-33 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables interleukin-33 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interleukin-33-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of T-helper 1 type immune response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type II interferon production IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-5 production IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interleukin-1 receptor-like 1
Names
interleukin-33 receptor alpha chain
lymphocyte antigen 84
NP_001020773.1
NP_001281100.1
NP_001407277.1
NP_001407278.1
NP_001407279.1
NP_001407280.1
NP_034873.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025602.4 → NP_001020773.1  interleukin-1 receptor-like 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001020773.1

    Status: VALIDATED

    Source sequence(s)
    AC167126, AC167168
    Consensus CDS
    CCDS35548.1
    UniProtKB/Swiss-Prot
    P14719, Q05208
    UniProtKB/TrEMBL
    Q3UM53
    Related
    ENSMUSP00000095379.4, ENSMUST00000097772.10
    Conserved Domains (4) summary
    pfam01582
    Location:385 → 540
    TIR; TIR domain
    cd00096
    Location:37 → 42
    Ig; Ig strand B [structural motif]
    cd05757
    Location:124 → 210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:33 → 97
    Ig; Immunoglobulin domain

  2. NM_001294171.2 → NP_001281100.1  interleukin-1 receptor-like 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001281100.1

    Status: VALIDATED

    Source sequence(s)
    AC167126, AC167168
    Consensus CDS
    CCDS56626.1
    UniProtKB/TrEMBL
    Q5D095
    Related
    ENSMUSP00000134351.2, ENSMUST00000174335.8
    Conserved Domains (3) summary
    cd05757
    Location:124 → 210
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:27 → 110
    IG_like; Immunoglobulin like
    cl11960
    Location:27 → 110
    Ig; Immunoglobulin domain

  3. NM_001420348.1 → NP_001407277.1  interleukin-1 receptor-like 1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC167126, AC167168
    UniProtKB/Swiss-Prot
    P14719, Q05208

  4. NM_001420349.1 → NP_001407278.1  interleukin-1 receptor-like 1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC167126, AC167168
    UniProtKB/Swiss-Prot
    P14719, Q05208

  5. NM_001420350.1 → NP_001407279.1  interleukin-1 receptor-like 1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC167126, AC167168
    UniProtKB/Swiss-Prot
    P14719, Q05208

  6. NM_001420351.1 → NP_001407280.1  interleukin-1 receptor-like 1 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC167126, AC167168

  7. NM_010743.4 → NP_034873.2  interleukin-1 receptor-like 1 isoform b precursor

    See identical proteins and their annotated locations for NP_034873.2

    Status: VALIDATED

    Source sequence(s)
    AC167126, AC167168
    Consensus CDS
    CCDS56626.1
    UniProtKB/TrEMBL
    Q5D095
    Related
    ENSMUSP00000133784.2, ENSMUST00000173514.8
    Conserved Domains (3) summary
    cd05757
    Location:124 → 210
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:27 → 110
    IG_like; Immunoglobulin like
    cl11960
    Location:27 → 110
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    40444105..40504575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14719.2 GenPept UniProtKB/Swiss-Prot:P14719

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