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Rtkn2 rhotekin 2 [ Mus musculus (house mouse) ]

Gene ID: 170799, updated on 5-Mar-2024

Summary

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Official Symbol
Rtkn2provided by MGI
Official Full Name
rhotekin 2provided by MGI
Primary source
MGI:MGI:2158417
See related
Ensembl:ENSMUSG00000037846 AllianceGenome:MGI:2158417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mbf; Plekhk1; B130039D23Rik
Summary
Acts upstream of or within hemopoiesis and positive regulation of cell population proliferation. Located in plasma membrane. Is expressed in embryo and lung. Orthologous to human RTKN2 (rhotekin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 8.1), CNS E11.5 (RPKM 1.4) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B5.1; 10 35.06 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (67815371..67894259)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (67979566..68058429)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27009 Neighboring gene zinc finger protein 365 Neighboring gene STARR-seq mESC enhancer starr_27010 Neighboring gene RIKEN cDNA 4930521O17 gene Neighboring gene STARR-positive B cell enhancer ABC_E5144 Neighboring gene STARR-seq mESC enhancer starr_27014 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:67544592-67544803 Neighboring gene STARR-seq mESC enhancer starr_27016 Neighboring gene AT-rich interaction domain 5B Neighboring gene STARR-seq mESC enhancer starr_27019 Neighboring gene STARR-seq mESC enhancer starr_27023 Neighboring gene STARR-positive B cell enhancer ABC_E9344 Neighboring gene STARR-seq mESC enhancer starr_27025 Neighboring gene predicted gene, 51770 Neighboring gene STARR-seq mESC enhancer starr_27026 Neighboring gene STARR-positive B cell enhancer ABC_E8342 Neighboring gene STARR-positive B cell enhancer ABC_E3891 Neighboring gene STARR-positive B cell enhancer ABC_E5145 Neighboring gene STARR-seq mESC enhancer starr_27031 Neighboring gene STARR-seq mESC enhancer starr_27032 Neighboring gene STARR-seq mESC enhancer starr_27034 Neighboring gene STARR-positive B cell enhancer ABC_E10619 Neighboring gene STARR-positive B cell enhancer ABC_E8343 Neighboring gene STARR-positive B cell enhancer ABC_E10620 Neighboring gene STARR-seq mESC enhancer starr_27036 Neighboring gene STARR-seq mESC enhancer starr_27037 Neighboring gene RIKEN cDNA 4930545H06 gene Neighboring gene STARR-seq mESC enhancer starr_27038

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic approach and phenotype-based complementation screening for identification of stroma cell-derived proteins involved in cell proliferation. Tulin EE, et al. Exp Cell Res, 2002 Jan 1. PMID 11740862
  2. Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing. Nicod J, et al. Nat Genet, 2016 Aug. PMID 27376238, Free PMC Article
  3. Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo. Little DR, et al. Nat Commun, 2021 May 4. PMID 33947861, Free PMC Article
  4. WNT5a-ROR Signaling Is Essential for Alveologenesis. Li C, et al. Cells, 2020 Feb 7. PMID 32046118, Free PMC Article
  5. CIN85 interacting proteins in B cells-specific role for SHIP-1. Büchse T, et al. Mol Cell Proteomics, 2011 Oct. PMID 21725061, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC189880

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in hemopoiesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hemopoiesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rhotekin-2
Names
PH domain-containing family K member 1
membrane bound factor
pleckstrin homology domain containing, family K member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359318.1 → NP_001346247.1  rhotekin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC160409, AK030986, AK052662, AK087239, AV026520
    Consensus CDS
    CCDS88018.1
    UniProtKB/Swiss-Prot
    Q14B46, Q8BFP3, Q8BFP8, Q8BFQ0
    UniProtKB/TrEMBL
    E9QP76
    Related
    ENSMUSP00000112946.2, ENSMUST00000118160.8
    Conserved Domains (3) summary
    smart00742
    Location:12 → 67
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    cd13249
    Location:282 → 390
    PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
    pfam08174
    Location:94 → 239
    Anillin; Cell division protein anillin

  2. NM_001359319.1 → NP_001346248.1  rhotekin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC160409, AK030986, AK045134, AK052662, AK087239, AV026520
    Consensus CDS
    CCDS88017.1
    UniProtKB/TrEMBL
    E9QP76
    Related
    ENSMUSP00000112419.2, ENSMUST00000117086.2
    Conserved Domains (3) summary
    smart00742
    Location:12 → 67
    Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
    cd13249
    Location:279 → 387
    PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
    pfam08174
    Location:91 → 236
    Anillin; Cell division protein anillin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    67815371..67894259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155654.1 → XP_036011547.1  rhotekin-2 isoform X2

    Conserved Domains (1) summary
    cd13249
    Location:4 → 112
    PH_rhotekin2; Anillin Pleckstrin homology (PH) domain

  2. XM_006513292.5 → XP_006513355.1  rhotekin-2 isoform X1

    Conserved Domains (1) summary
    cd13249
    Location:62 → 170
    PH_rhotekin2; Anillin Pleckstrin homology (PH) domain

RNA

  1. XR_003948599.2 RNA Sequence

  2. XR_004936111.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081346.1: Suppressed sequence

    Description
    NM_001081346.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

  2. NM_133244.2: Suppressed sequence

    Description
    NM_133244.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14B46.2 GenPept UniProtKB/Swiss-Prot:Q14B46

Gene LinkOut

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