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Glcci1 glucocorticoid induced transcript 1 [ Mus musculus (house mouse) ]

Gene ID: 170772, updated on 5-Mar-2024

Summary

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Official Symbol
Glcci1provided by MGI
Official Full Name
glucocorticoid induced transcript 1provided by MGI
Primary source
MGI:MGI:2179717
See related
Ensembl:ENSMUSG00000029638 AllianceGenome:MGI:2179717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gig18; Tssn1; Fam117c; 2310047L21Rik; A130036A18Rik
Summary
Located in cytoplasm. Is expressed in several structures, including apical ectodermal ridge; axial skeleton; central nervous system; paraxial mesenchyme; and sensory organ. Orthologous to human GLCCI1 (glucocorticoid induced 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 64.9), testis adult (RPKM 19.8) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A1; 6 4.38 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (8509600..8597549)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (8509600..8597549)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A430035B10 gene Neighboring gene STARR-positive B cell enhancer ABC_E126 Neighboring gene predicted gene, 26075 Neighboring gene predicted gene, 52941 Neighboring gene F-box protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E11313 Neighboring gene predicted gene, 35621 Neighboring gene STARR-positive B cell enhancer ABC_E8826 Neighboring gene STARR-seq mESC enhancer starr_15122 Neighboring gene islet cell autoantigen 1 Neighboring gene STARR-positive B cell enhancer ABC_E8827 Neighboring gene STARR-positive B cell enhancer ABC_E9660 Neighboring gene STARR-seq mESC enhancer starr_15123 Neighboring gene predicted gene, 53310 Neighboring gene predicted gene, 53311

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of GLCCI1 in mouse spermatogenesis. Takada M, et al. FASEB J, 2023 Jan. PMID 36468710
  2. GLCCI1 reduces collagen deposition and airway hyper-responsiveness in a mouse asthma model through binding with WD repeat domain 45B. Xun Q, et al. J Cell Mol Med, 2021 Jul. PMID 34050597, Free PMC Article
  3. Glucocorticoid induced transcript 1 represses airway remodeling of asthmatic mouse via inhibiting IL-13/periostin/TGF-β1 signaling. Xun Q, et al. Int Immunopharmacol, 2021 Aug. PMID 33895479
  4. Transcriptional control of steroid-regulated apoptosis in murine thymoma cells. Chapman MS, et al. Mol Endocrinol, 1996 Aug. PMID 8843413
  5. Isolation of differentially expressed sequence tags from steroid-responsive cells using mRNA differential display. Chapman MS, et al. Mol Cell Endocrinol, 1995 Feb 27. PMID 7758820

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GLCCI1 reduces collagen deposition and airway hyper-responsiveness in a mouse asthma model through binding with WD repeat domain 45B.
    Title: GLCCI1 reduces collagen deposition and airway hyper-responsiveness in a mouse asthma model through binding with WD repeat domain 45B.
  2. Glucocorticoid induced transcript 1 represses airway remodeling of asthmatic mouse via inhibiting IL-13/periostin/TGF-beta1 signaling.
    Title: Glucocorticoid induced transcript 1 represses airway remodeling of asthmatic mouse via inhibiting IL-13/periostin/TGF-β1 signaling.
  3. These findings suggest that Glcci1 is a new marker of a subpopulation of lateral ganglionic eminence ventricular zone progenitor cells in the Gsx2 lineage.
    Title: Characterization of Glcci1 expression in a subpopulation of lateral ganglionic eminence progenitors in the mouse telencephalon.
  4. Glcci1 promotes the normal development and maintenance of podocyte structure and function.
    Title: Glcci1 deficiency leads to proteinuria.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glucocorticoid-induced transcript 1 protein
Names
glucocorticoid-induced gene 18 protein
testhymin
thymocyte/spermatocyte selection protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286728.1 → NP_001273657.1  glucocorticoid-induced transcript 1 protein isoform 2

    See identical proteins and their annotated locations for NP_001273657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 5' terminal exon, initiates translation at a downstream start codon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK029524, AK037672, AV355078, AY098636, CA561411
    Consensus CDS
    CCDS71724.1
    UniProtKB/TrEMBL
    A0A0R4J1Z9
    Related
    ENSMUSP00000125079.2, ENSMUST00000162567.8
    Conserved Domains (1) summary
    pfam15388
    Location:1 → 281
    FAM117; Protein Family FAM117

  2. NM_001286729.1 → NP_001273658.1  glucocorticoid-induced transcript 1 protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK029524, AK037672, AV355078, AY098636
    Consensus CDS
    CCDS71725.1
    UniProtKB/Swiss-Prot
    Q8K3I9
    Related
    ENSMUSP00000124167.2, ENSMUST00000161217.8
    Conserved Domains (1) summary
    pfam15388
    Location:1 → 280
    FAM117; Protein Family FAM117

  3. NM_133236.3 → NP_573499.2  glucocorticoid-induced transcript 1 protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC156290, AK037672, AV355078, AY098636, BG081330, CN720421, DV652660
    Consensus CDS
    CCDS19910.2
    UniProtKB/Swiss-Prot
    Q80YT1, Q8CEA5, Q8K3I9, Q925C1
    UniProtKB/TrEMBL
    E9QKK4
    Related
    ENSMUSP00000069444.9, ENSMUST00000064285.15
    Conserved Domains (1) summary
    pfam15388
    Location:159 → 468
    FAM117; Protein Family FAM117

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    8509600..8597549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3I9.1 GenPept UniProtKB/Swiss-Prot:Q8K3I9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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