Ly75 lymphocyte antigen 75 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ly75provided by MGI
Official Full Name: lymphocyte antigen 75provided by MGI
Primary source: MGI:MGI:106662
See related: Ensembl:ENSMUSG00000026980 AllianceGenome:MGI:106662
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD205; DEC205; DEC-205
Summary: Predicted to enable signaling receptor activity. Predicted to act upstream of or within endocytosis. Located in external side of plasma membrane. Is expressed in thymus and thymus primordium. Orthologous to several human genes including LY75-CD302 (LY75-CD302 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 6.5), placenta adult (RPKM 5.6) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1; 2 34.54 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (60122447..60213617, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (60292103..60383273, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response.
Title: Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response.
LY75 Suppression in Mesenchymal Epithelial Ovarian Cancer Cells Generates a Stable Hybrid EOC Cellular Phenotype, Associated with Enhanced Tumor Initiation, Spreading and Resistance to Treatment in Orthotopic Xenograft Mouse Model.
Title: LY75 Suppression in Mesenchymal Epithelial Ovarian Cancer Cells Generates a Stable Hybrid EOC Cellular Phenotype, Associated with Enhanced Tumor Initiation, Spreading and Resistance to Treatment in Orthotopic Xenograft Mouse Model.
The results showed that Ly75 is a true Pbwg1.5 quantitative trait gene for resistance to obesity. The finding provides a novel insight for obesity biology.
Title: Genetic identification of Ly75 as a novel quantitative trait gene for resistance to obesity in mice.
this study shows that CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in Hepatitis B viral antigens transgenic mice by promoting the interaction of NKT cells with Kupffer cells
Title: CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in HBsAg transgenic mice by promoting the interaction of NKT cells with Kupffer cells.
Antigen targeting to DEC-205 on dendritic cells leads to an IL-10-dependent downregulation of CXCR3 expression on differentiated antigen-specific Th1 cells in vivo. This downregulation interferes with the migration of Th1 cells into the gut and protects mice against severe acute and relapsing intestinal inflammation.
Title: IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites.
DNA vaccines encoding DEC205-targeted antigens induce peripheral tolerance rather than immunity
Title: DNA vaccines encoding DEC205-targeted antigens: immunity or tolerance?
The DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8 T cells independently of PD-1 and PD-L1.
Title: DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8⁺ T cells independently of PD-1 and PD-L1.
Through analysis of both polyclonal and monoclonal transgenic TCR T-cell development in the context of CD205 deficiency, we demonstrate that CD205 does not play an overt role in T cell development or selection.
Title: Normal T cell selection occurs in CD205-deficient thymic microenvironments.
Introduction of a labile dipeptide linker at the N terminus of a T-cell epitope improves proteasome-dependent class I MHC-restricted peptide cross-presentation when delivered by alphaDEC205 in vitro and in vivo.
Title: Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes.
Data indicate that the interaction between the PE-Cy5.5 conjugates and the cells expressing mDEC205 appears distinctive, since none of the PE-Cy5.5 conjugates bind to the cells that express human DEC205 on surface.
Title: PE-Cy5.5 conjugates bind to the cells expressing mouse DEC205/CD205.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224918

NoName (e-PCR)
- UniSTS:234404

U19271 (e-PCR)
- UniSTS:178628

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lymphocyte antigen 75

Names: ly-75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013825.4 → NP_038853.2 lymphocyte antigen 75 precursor

See identical proteins and their annotated locations for NP_038853.2

Status: VALIDATED

Source sequence(s)

AL935326

Consensus CDS

CCDS38126.1

UniProtKB/Swiss-Prot

B2RWW5, Q60767, Q8C7T3, Q91XL8, Q9QUZ6

UniProtKB/TrEMBL

A2AW86

Related

ENSMUSP00000028362.9, ENSMUST00000028362.9

Conserved Domains (5) summary

smart00059
Location:162 → 209

FN2; Fibronectin type 2 domain

cd00037
Location:1407 → 1514

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

smart00034
Location:216 → 341

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00458
Location:38 → 125

RICIN; Ricin-type beta-trefoil

cd00161
Location:40 → 125

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...