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Sgk3 serum/glucocorticoid regulated kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 170755, updated on 5-Mar-2024

Summary

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Official Symbol
Sgk3provided by MGI
Official Full Name
serum/glucocorticoid regulated kinase 3provided by MGI
Primary source
MGI:MGI:2182368
See related
Ensembl:ENSMUSG00000025915 AllianceGenome:MGI:2182368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
fy; fz; Cisk; 2510015P22Rik; A330005P07Rik
Summary
Enables protein serine/threonine kinase activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytoplasmic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to several human genes including C8orf44-SGK3 (C8orf44-SGK3 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 7.0), liver E14 (RPKM 4.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 A2; 1 2.08 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (9868355..9972795)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (9798130..9902570)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene valosin containing protein (p97)/p47 complex interacting protein 1 Neighboring gene RIKEN cDNA 1700034P13 gene Neighboring gene STARR-seq mESC enhancer starr_00169 Neighboring gene STARR-seq mESC enhancer starr_00171 Neighboring gene predicted gene, 39590 Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7715 Neighboring gene predicted pseudogene 6195 Neighboring gene STARR-seq mESC enhancer starr_00172 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene minichromosome maintenance domain containing 2 Neighboring gene small nucleolar RNA, C/D box 87 Neighboring gene small nucleolar RNA host gene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction. Peng LQ, et al. FASEB J, 2018 Feb. PMID 28935820, Free PMC Article
  2. SGK3 Sensitivity of Voltage Gated K+ Channel Kv1.5 (KCNA5). Ahmed M, et al. Cell Physiol Biochem, 2016. PMID 26824455
  3. SGK3 regulates Ca(2+) entry and migration of dendritic cells. Schmid E, et al. Cell Physiol Biochem, 2012. PMID 23171960, Free PMC Article
  4. Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Bhandaru M, et al. Kidney Int, 2011 Jul. PMID 21451460, Free PMC Article
  5. Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3. Zemtsova IM, et al. Am J Physiol Cell Physiol, 2010 Nov. PMID 20686074, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SGK3 promotes vascular calcification via Pit-1 in chronic kidney disease.
    Title: SGK3 promotes vascular calcification via Pit-1 in chronic kidney disease.
  2. MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in Vascular Endothelial Cells.
    Title: MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in Vascular Endothelial Cells.
  3. The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin and ezrin in podocytes was associated with the stability of the PC/ezrin complex.
    Title: The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex.
  4. Study data from human hepatocellular carcinoma (HCC) liver samples, human HCC cells, and Sgk3 knockout mice model suggest that SGK3 plays a role in transducing helical domain mutant PIK3CA signaling during liver tumor development.
    Title: Functional role of SGK3 in PI3K/Pten driven liver tumor development.
  5. Taken together, these data strongly suggest that SGK3 plays a significant role in regulating podocyte function, likely by controlling the expression and activity of GSK3.
    Title: Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction.
  6. SGK1 and SGK3 are expressed in multiple microglial cell lines. SGK1 and SGK3 may play an important role in regulating microglial viability and inflammatory responses.
    Title: Serum- and glucocorticoid-inducible kinases in microglia.
  7. SGK3 is a positive regulator of KCNA5, which is at least partially effective by abrogating the effect of Nedd4-2.
    Title: SGK3 Sensitivity of Voltage Gated K+ Channel Kv1.5 (KCNA5).
  8. SGK3 contributes to the regulation of store-operated calcium entry into and migration of dendritic cells.
    Title: SGK3 regulates Ca(2+) entry and migration of dendritic cells.
  9. SGK3 plays a previously unappreciated role in glucose homeostasis, likely through direct effects within pancreatic beta-cells, to stimulate proliferation and insulin release
    Title: Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.
  10. The study identifies SGK3 as a novel endosomal kinase that acutely regulates Na(+)/H(+) exchanger 3 (NHE3) in a PI3K-dependent mechanism.
    Title: Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Associated conditions

Description Tests
fuzzy
GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in localization EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Sgk3
Names
cytokine-independent survival kinase
NP_001032848.1
NP_573483.1
NP_808215.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037759.1 → NP_001032848.1  serine/threonine-protein kinase Sgk3

    See identical proteins and their annotated locations for NP_001032848.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC102570, AC158928, AK030314
    Consensus CDS
    CCDS14816.1
    UniProtKB/Swiss-Prot
    Q3UAY2, Q9ERE3
    UniProtKB/TrEMBL
    Q3U9B2
    Related
    ENSMUSP00000127462.2, ENSMUST00000171265.8
    Conserved Domains (3) summary
    cd06870
    Location:12 → 120
    PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
    smart00220
    Location:162 → 419
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05604
    Location:165 → 490
    STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

  2. NM_133220.2 → NP_573483.1  serine/threonine-protein kinase Sgk3

    See identical proteins and their annotated locations for NP_573483.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC102570, AC158928, AK031133, BB856423
    Consensus CDS
    CCDS14816.1
    UniProtKB/Swiss-Prot
    Q3UAY2, Q9ERE3
    UniProtKB/TrEMBL
    Q3U9B2
    Related
    ENSMUSP00000126861.2, ENSMUST00000168907.8
    Conserved Domains (3) summary
    cd06870
    Location:12 → 120
    PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
    smart00220
    Location:162 → 419
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05604
    Location:165 → 490
    STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

  3. NM_177547.3 → NP_808215.2  serine/threonine-protein kinase Sgk3

    See identical proteins and their annotated locations for NP_808215.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC102570, AC158928, AK031133, BB856423
    Consensus CDS
    CCDS14816.1
    UniProtKB/Swiss-Prot
    Q3UAY2, Q9ERE3
    UniProtKB/TrEMBL
    Q3U9B2
    Related
    ENSMUSP00000130078.2, ENSMUST00000166384.8
    Conserved Domains (3) summary
    cd06870
    Location:12 → 120
    PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
    smart00220
    Location:162 → 419
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05604
    Location:165 → 490
    STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    9868355..9972795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERE3.1 GenPept UniProtKB/Swiss-Prot:Q9ERE3

Gene LinkOut

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