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Smco4 single-pass membrane protein with coiled-coil domains 4 [ Mus musculus (house mouse) ]

Gene ID: 170748, updated on 5-Mar-2024

Summary

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Official Symbol
Smco4provided by MGI
Official Full Name
single-pass membrane protein with coiled-coil domains 4provided by MGI
Primary source
MGI:MGI:3039636
See related
Ensembl:ENSMUSG00000058173 AllianceGenome:MGI:3039636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fn5
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SMCO4 (single-pass membrane protein with coiled-coil domains 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 6.3), lung adult (RPKM 4.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A2; 9 4.95 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15379736..15456556)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15468440..15545260)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene predicted gene, 39294 Neighboring gene spermatogenesis associated 2 pseudogene Neighboring gene predicted gene, 35176 Neighboring gene STARR-positive B cell enhancer ABC_E2281 Neighboring gene predicted gene, 51703 Neighboring gene STARR-seq mESC enhancer starr_23385 Neighboring gene predicted gene, 46152 Neighboring gene deuterosome assembly protein 1 Neighboring gene STARR-seq mESC enhancer starr_23386 Neighboring gene RIKEN cDNA 4930540M03 gene Neighboring gene predicted gene, 39295

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts. Kehrer-Sawatzki H, et al. Gene, 2000 Jun 13. PMID 10863097
  2. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
single-pass membrane and coiled-coil domain-containing protein 4
Names
UPF0443 protein C11orf75 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359604.1 → NP_001346533.1  single-pass membrane and coiled-coil domain-containing protein 4

    Status: VALIDATED

    Source sequence(s)
    AC155249, AC155259
    Consensus CDS
    CCDS22838.1
    UniProtKB/Swiss-Prot
    Q8VD32, Q9JIS3
    Related
    ENSMUSP00000150121.2, ENSMUST00000215907.2
    Conserved Domains (1) summary
    pfam15012
    Location:1 → 55
    DUF4519; Domain of unknown function (DUF4519)

  2. NM_133214.2 → NP_573477.2  single-pass membrane and coiled-coil domain-containing protein 4

    See identical proteins and their annotated locations for NP_573477.2

    Status: VALIDATED

    Source sequence(s)
    AF197136, CO800370
    Consensus CDS
    CCDS22838.1
    UniProtKB/Swiss-Prot
    Q8VD32, Q9JIS3
    Related
    ENSMUSP00000044228.4, ENSMUST00000045620.10
    Conserved Domains (1) summary
    pfam15012
    Location:1 → 55
    DUF4519; Domain of unknown function (DUF4519)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    15379736..15456556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510043.2 → XP_006510106.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X1

    Conserved Domains (1) summary
    pfam15012
    Location:107 → 161
    DUF4519; Domain of unknown function (DUF4519)

  2. XM_036154632.1 → XP_036010525.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q8VD32, Q9JIS3
    Conserved Domains (1) summary
    pfam15012
    Location:1 → 55
    DUF4519; Domain of unknown function (DUF4519)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIS3.2 GenPept UniProtKB/Swiss-Prot:Q9JIS3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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