Pilrb1 paired immunoglobin-like type 2 receptor beta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pilrb1provided by MGI
Official Full Name: paired immunoglobin-like type 2 receptor beta 1provided by MGI
Primary source: MGI:MGI:2450532
See related: Ensembl:ENSMUSG00000066684 AllianceGenome:MGI:2450532
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fdact; Pilrb; FDFACT
Summary: Enables MHC class I protein binding activity. Involved in negative regulation of osteoclast differentiation. Acts upstream of or within myeloid dendritic cell activation. Located in plasma membrane. Orthologous to human PILRA (paired immunoglobin like type 2 receptor alpha) and PILRB (paired immunoglobin like type 2 receptor beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 5.4), liver E18 (RPKM 2.8) and 15 other tissues See more
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Genomic context

Location:: 5 G2; 5 76.82 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137850403..137856687, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137852141..137858425, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upon neutrophil arrest, binding of PILR-beta1 to CD99 ceases, shifting the signaling balance towards inhibitory PILR-alpha. This enables integrin deactivation and supports cell diapedesis in venules of the mouse cremaster muscle.
Title: Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α.
Data show that PILRbeta is important for regulating aberrant inflammatory responses through IL-27 production.
Title: The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production.
Activation of PILRa or deletion of PILRb helps to control acute Staphylococcus aureus-mediated pneumonia and attenuate the inflammatory response.
Title: Modulation of paired immunoglobulin-like type 2 receptor signaling alters the host response to Staphylococcus aureus-induced pneumonia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1) 1 citation

General gene information

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Markers

34.MMHAP64FRD10.seq (e-PCR)
- UniSTS:124103

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class I protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables MHC class I protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within myeloid dendritic cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: paired immunoglobulin-like type 2 receptor beta

Names: activating receptor PILR-beta; cell surface receptor FDFACT; immunoglobulin-like cell surface receptor FDFACT, activating counterpart

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133209.2 → NP_573472.2 paired immunoglobulin-like type 2 receptor beta precursor

See identical proteins and their annotated locations for NP_573472.2

Status: VALIDATED

Source sequence(s)

AJ400847, BY235581

Consensus CDS

CCDS51675.1

UniProtKB/Swiss-Prot

Q2YFS2

UniProtKB/TrEMBL

B7ZWH4

Related

ENSMUSP00000106606.3, ENSMUST00000110978.7

Conserved Domains (1) summary

cl11960
Location:40 → 136

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

137850403..137856687 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240934.3 → XP_011239236.1 paired immunoglobulin-like type 2 receptor beta isoform X2

Conserved Domains (1) summary

cl11960
Location:21 → 69

Ig; Immunoglobulin domain
XM_011240933.3 → XP_011239235.1 paired immunoglobulin-like type 2 receptor beta isoform X1

Conserved Domains (1) summary

cl11960
Location:122 → 218

Ig; Immunoglobulin domain