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Klra17 killer cell lectin-like receptor, subfamily A, member 17 [ Mus musculus (house mouse) ]

Gene ID: 170733, updated on 8-Feb-2024

Summary

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Official Symbol
Klra17provided by MGI
Official Full Name
killer cell lectin-like receptor, subfamily A, member 17provided by MGI
Primary source
MGI:MGI:2180674
See related
Ensembl:ENSMUSG00000014543 AllianceGenome:MGI:2180674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly49q; Ly49q1
Summary
Enables MHC class I protein binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Klra17 in Genome Data Viewer
Location:
6 F3; 6 63.44 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129808117..129853635, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129831154..129876672, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57684 Neighboring gene killer cell lectin-like receptor subfamily H, member 1 Neighboring gene STARR-seq mESC enhancer starr_17482 Neighboring gene predicted gene, 23977 Neighboring gene killer cell lectin-like receptor, subfamily A, member 5 Neighboring gene predicted gene, 40404

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The inhibitory NK receptor Ly49Q protects plasmacytoid dendritic cells from pyroptotic cell death. Sasawatari S, et al. Mol Immunol, 2021 Jul. PMID 33932686
  2. The ITIM Domain-Containing NK Receptor Ly49Q Impacts Pulmonary Infection by Mediating Neutrophil Functions. Margraf A, et al. J Immunol, 2018 Jun 15. PMID 29712775
  3. Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation. Hayashi M, et al. Biochem Biophys Res Commun, 2010 Mar 12. PMID 20153723
  4. The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking. Sasawatari S, et al. Immunity, 2010 Feb 26. PMID 20153219
  5. Ly49Q ligand expressed by activated B cells induces plasmacytoid DC maturation. Toma-Hirano M, et al. Eur J Immunol, 2009 May. PMID 19350550

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The inhibitory NK receptor Ly49Q protects plasmacytoid dendritic cells from pyroptotic cell death.
    Title: The inhibitory NK receptor Ly49Q protects plasmacytoid dendritic cells from pyroptotic cell death.
  2. Ly49Q regulates integrin activation and neutrophil recruitment and is required for an adequate immune response in pulmonary infection.
    Title: The ITIM Domain-Containing NK Receptor Ly49Q Impacts Pulmonary Infection by Mediating Neutrophil Functions.
  3. This study provides an example in which an ITIM-bearing receptor Ly49Q functions as a positive regulator of osteoclast differentiation.
    Title: Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation.
  4. crucial for the neutrophil polarization and tissue infiltration during inflammation
    Title: The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.
  5. A novel mechanism by which TLR9 signaling is controlled through the spatiotemporal regulation of membrane trafficking by the immunoreceptor tyrosine-based inhibitory motif-bearing receptor Ly49Q.
    Title: Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q.
  6. Results show that class I MHC recognition by Ly49Q on plasmacytoid dendritic cells is necessary for optimal activation of innate immune responses in vivo.
    Title: Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.
  7. Ly49Q serves a role for the biological functions of certain dendritic cell subsets through recognition of MHC class I or related molecules.
    Title: Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic cells in a cellular maturation- and cytokine stimulation-dependent manner.
  8. These results demonstrate that Ly49Q efficiently binds H-2K(b) ligand.
    Title: Recognition of H-2K(b) by Ly49Q suggests a role for class Ia MHC regulation of plasmacytoid dendritic cell function.
  9. has unique features different from other known Ly49 family members and appears to be involved in regulation of cytoskeletal architecture of macrophages through ITIM-mediated signaling
    Title: Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture.
  10. Different expression levels of inhibitory natural killer (NK) receptor Ly49Q define sequential developmental stages of murine plasmacytoid dendritic cells in bone marrow.
    Title: Development of murine plasmacytoid dendritic cells defined by increased expression of an inhibitory NK receptor, Ly49Q.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class I protein binding IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
killer cell lectin-like receptor, subfamily A, member 17
Names
NK receptor Ly-49Q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381962.1 → NP_001368891.1  killer cell lectin-like receptor, subfamily A, member 17 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AB033769, AC090563
    UniProtKB/TrEMBL
    Q6DUV0, Q8BJS9
    Related
    ENSMUSP00000014687.5, ENSMUST00000014687.11
    Conserved Domains (2) summary
    cd03593
    Location:146 → 261
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:41 → 159
    Ly49; Ly49-like protein, N-terminal region

  2. NM_133203.5 → NP_573466.3  killer cell lectin-like receptor, subfamily A, member 17 isoform 2

    See identical proteins and their annotated locations for NP_573466.3

    Status: VALIDATED

    Source sequence(s)
    AB033769, AK080021
    Consensus CDS
    CCDS39664.1
    UniProtKB/TrEMBL
    Q6DUV0, Q9JMA4
    Related
    ENSMUSP00000114108.3, ENSMUST00000122219.2
    Conserved Domains (2) summary
    cd03593
    Location:145 → 260
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:40 → 158
    Ly49; Ly49-like protein, N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129808117..129853635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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