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Tmem37 transmembrane protein 37 [ Mus musculus (house mouse) ]

Gene ID: 170706, updated on 16-Apr-2024

Summary

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Official Symbol
Tmem37provided by MGI
Official Full Name
transmembrane protein 37provided by MGI
Primary source
MGI:MGI:2157899
See related
Ensembl:ENSMUSG00000050777 AllianceGenome:MGI:2157899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pr; Pr1
Summary
Predicted to enable calcium channel activity and voltage-gated ion channel activity. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in early tubule and renal interstitium. Orthologous to human TMEM37 (transmembrane protein 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 185.4), kidney adult (RPKM 89.5) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem37 in Genome Data Viewer
Location:
1 E2.3; 1 52.6 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (119995106..120001799, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (120067377..120074069, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene secretin receptor Neighboring gene predicted gene, 33764 Neighboring gene STARR-seq mESC enhancer starr_02045 Neighboring gene predicted gene, 41936 Neighboring gene predicted gene, 41937 Neighboring gene STARR-positive B cell enhancer ABC_E10029 Neighboring gene predicted gene, 41938

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A family of gamma-like calcium channel subunits. Klugbauer N, et al. FEBS Lett, 2000 Mar 24. PMID 10734232
  2. Calcium channel gamma subunits provide insights into the evolution of this gene family. Chu PJ, et al. Gene, 2001 Dec 12. PMID 11738816
  3. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
voltage-dependent calcium channel gamma-like subunit
Names
neuronal voltage-gated calcium channel gamma-like subunit
protein distantly related to to the gamma subunit family
voltage-dependent calcium channel gamma subunit-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019432.3 → NP_062305.1  voltage-dependent calcium channel gamma-like subunit

    See identical proteins and their annotated locations for NP_062305.1

    Status: VALIDATED

    Source sequence(s)
    AC165443
    Consensus CDS
    CCDS15229.1
    UniProtKB/Swiss-Prot
    Q543K0, Q9JJV3
    Related
    ENSMUSP00000050862.8, ENSMUST00000056089.8
    Conserved Domains (1) summary
    pfam15108
    Location:8 → 189
    TMEM37; Voltage-dependent calcium channel gamma-like subunit protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    119995106..120001799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_878316.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJV3.1 GenPept UniProtKB/Swiss-Prot:Q9JJV3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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