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Snx18 sorting nexin 18 [ Mus musculus (house mouse) ]

Gene ID: 170625, updated on 11-Apr-2024

Summary

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Official Symbol
Snx18provided by MGI
Official Full Name
sorting nexin 18provided by MGI
Primary source
MGI:MGI:2137642
See related
Ensembl:ENSMUSG00000042364 AllianceGenome:MGI:2137642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Snag1
Summary
Enables phosphatidylinositol binding activity. Predicted to be involved in several processes, including cytoskeleton-dependent cytokinesis; endosomal transport; and positive regulation of GTPase activity. Predicted to act upstream of or within cell division. Located in growth cone and neuronal cell body. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and immune system. Orthologous to human SNX18 (sorting nexin 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 28.8), bladder adult (RPKM 12.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 D2.2; 13 64.0 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (113728715..113755100, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (113592179..113618564, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921509O07 gene Neighboring gene predicted gene, 31191 Neighboring gene predicted gene, 34471 Neighboring gene STARR-seq mESC enhancer starr_35712 Neighboring gene predicted gene, 53817 Neighboring gene predicted gene, 34528 Neighboring gene STARR-seq mESC enhancer starr_35713 Neighboring gene STARR-seq mESC enhancer starr_35714 Neighboring gene STARR-seq mESC enhancer starr_35715 Neighboring gene STARR-seq mESC enhancer starr_35719 Neighboring gene STARR-seq mESC enhancer starr_35720 Neighboring gene STARR-positive B cell enhancer mm9_chr13:114408812-114409113 Neighboring gene STARR-positive B cell enhancer mm9_chr13:114429053-114429354 Neighboring gene predicted gene, 34586 Neighboring gene STARR-seq mESC enhancer starr_35726 Neighboring gene heat shock protein 3 Neighboring gene predicted gene, 53818 Neighboring gene STARR-seq mESC enhancer starr_35729 Neighboring gene STARR-seq mESC enhancer starr_35731

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells. Thornhill PB, et al. FEBS Lett, 2007 Sep 18. PMID 17761170
  2. Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons. Nakazawa S, et al. J Histochem Cytochem, 2011 Feb. PMID 21339182, Free PMC Article
  3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNX18 may play an active role in axonal elongation
    Title: Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cleavage furrow formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cleavage furrow formation ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sorting nexin-18
Names
sorting nexin associated golgi protein 1
sorting nexin-associated Golgi protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130796.4 → NP_570614.2  sorting nexin-18

    See identical proteins and their annotated locations for NP_570614.2

    Status: VALIDATED

    Source sequence(s)
    BC063089, BC137801, BP763454
    Consensus CDS
    CCDS36784.1
    UniProtKB/Swiss-Prot
    Q91ZR2
    UniProtKB/TrEMBL
    Q8C788
    Related
    ENSMUSP00000104864.4, ENSMUST00000109241.5
    Conserved Domains (3) summary
    cd07286
    Location:267 → 394
    PX_SNX18; The phosphoinositide binding Phox Homology domain of Sorting Nexin 18
    cd07670
    Location:406 → 612
    BAR_SNX18; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 18
    cd11897
    Location:4 → 58
    SH3_SNX18; Src Homology 3 domain of Sorting nexin 18

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    113728715..113755100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZR2.1 GenPept UniProtKB/Swiss-Prot:Q91ZR2

Gene LinkOut

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