U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Blnk B cell linker [ Mus musculus (house mouse) ]

Gene ID: 17060, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Blnkprovided by MGI
Official Full Name
B cell linkerprovided by MGI
Primary source
MGI:MGI:96878
See related
Ensembl:ENSMUSG00000061132 AllianceGenome:MGI:96878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bca; BASH; Ly57; Ly-57; Lyw-57; SLP-65
Summary
Predicted to enable SH2 domain binding activity; enzyme binding activity; and signaling adaptor activity. Involved in positive regulation of gene expression. Located in cytoplasm. Is expressed in several structures, including genitourinary system; gut; immune system; lung; and olfactory epithelium. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 4. Orthologous to human BLNK (B cell linker). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 24.5), colon adult (RPKM 14.5) and 14 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Blnk in Genome Data Viewer
Location:
19 C3; 19 34.26 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (40917371..40982664, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (40928927..40994221, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E030044B06 gene Neighboring gene STARR-seq mESC enhancer starr_46136 Neighboring gene predicted gene, 57494 Neighboring gene STARR-seq mESC enhancer starr_46138 Neighboring gene zinc finger protein 518A Neighboring gene microRNA 8092 Neighboring gene STARR-seq mESC enhancer starr_46139 Neighboring gene STARR-positive B cell enhancer ABC_E4279 Neighboring gene RIKEN cDNA C330026H20 gene Neighboring gene STARR-positive B cell enhancer mm9_chr19:41090421-41090722 Neighboring gene ribosomal protein S10 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. B cells promote tumor immunity against B16F10 melanoma. Kobayashi T, et al. Am J Pathol, 2014 Nov. PMID 25173132
  2. B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells. Jin G, et al. J Allergy Clin Immunol, 2013 Jun. PMID 23534976
  3. Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling. van Loo PF, et al. Immunity, 2007 Sep. PMID 17869135
  4. Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor. Meixlsperger S, et al. Immunity, 2007 Mar. PMID 17331747
  5. Association of the pre-B cell receptor (BCR) expression level with the quality of pre-BII cell differentiation reveals hierarchical pre-BCR function. Wang H, et al. Mol Immunol, 2007 Mar. PMID 17007932

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of Blnk and Foxo1 in tumor suppression in BCRABL1transformed proB cells.
    Title: Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells.
  2. The pre-B-cell receptor (pre-BCR) signaling molecules BLNK, BTK and BANK1 were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR signaling pathway.
    Title: ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.
  3. Authors demonstrate leukemogenicity of PAX5-PML by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk) is repressed by PAX5-PML in leukemia cells; enforced expression of Blnk increases survival despite introduction of PAX5-PML.
    Title: B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia.
  4. B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells.
    Title: B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells.
  5. Tumor suppressor BLNK is a target of transcriptional activation by PU.1 and Spi-B in the B cell lineage.
    Title: Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.
  6. a novel negative feedback regulation of BCR signaling by HPK1-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK
    Title: Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK).
  7. CMTM7 functions to link sIgM and BLNK in the plasma membrane.
    Title: Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor.
  8. Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 are both required for the onset and progression phases of B-cell antigen receptor signal transduction.
    Title: The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.
  9. malignant transformation of Btk/Slp65 double-deficient pre-B cells is independent of deregulated V(D)J recombination activity.
    Title: Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.
  10. Swip-1 provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent BCR-induced calcium flux.
    Title: Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
B-cell linker protein
Names
B-cell adapter containing a SH2 domain protein
B-cell adapter containing a Src homology 2 domain protein
cytoplasmic adapter protein
lymphocyte antigen 57
src homology 2 domain-containing leukocyte protein of 65 kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365054.1 → NP_001351983.1  B-cell linker protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117253, AC121873, AC126608
    Consensus CDS
    CCDS89391.1
    UniProtKB/TrEMBL
    D3YWR2
    Related
    ENSMUSP00000112473.2, ENSMUST00000117695.8
    Conserved Domains (2) summary
    cd09929
    Location:332 → 452
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    cl26464
    Location:99 → 327
    Atrophin-1; Atrophin-1 family

  2. NM_008528.5 → NP_032554.2  B-cell linker protein isoform 1

    See identical proteins and their annotated locations for NP_032554.2

    Status: VALIDATED

    Source sequence(s)
    AC117253, AC121873, AC126608
    Consensus CDS
    CCDS37983.1
    UniProtKB/Swiss-Prot
    O88504, Q9QUN3
    Related
    ENSMUSP00000057844.7, ENSMUST00000054769.7
    Conserved Domains (1) summary
    cd09929
    Location:335 → 455
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    40917371..40982664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QUN3.1 GenPept UniProtKB/Swiss-Prot:Q9QUN3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous