Klrb1a killer cell lectin-like receptor subfamily B member 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klrb1aprovided by MGI
Official Full Name: killer cell lectin-like receptor subfamily B member 1Aprovided by MGI
Primary source: MGI:MGI:107540
See related: Ensembl:ENSMUSG00000030361 AllianceGenome:MGI:107540
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly55a; NKRP12; Nkrp1a; ly-55A; NKR-P1A; Nkrp1-a; NKR-P1.7
Summary: Predicted to enable carbohydrate binding activity. Located in plasma membrane. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 10.5), mammary gland adult (RPKM 0.9) and 1 other tissue See more
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Genomic context

Location:: 6 F3; 6 63.06 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (128586190..128599897, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (128609227..128622934, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nkrp1 isoforms c1, c2 and f were expressed prevalently as homodimers, whereas the Nkrp1a displays larger proportion of monomers on the cell surface.
Title: Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells.
Solution structure of the lymphocyte receptor Nkrp1a reveals a distinct conformation of the long loop region as compared to in the crystal structure.
Title: Solution structure of the lymphocyte receptor Nkrp1a reveals a distinct conformation of the long loop region as compared to in the crystal structure.
structure of the H107R variant of the extracellular domain of the mouse natural killer cell receptor NKR-P1A has been determined by X-ray diffraction at 2.3 A resolution from a merohedrally twinned crystal
Title: Structure of the H107R variant of the extracellular domain of mouse NKR-P1A at 2.3 Å resolution.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491342

Ly55a (e-PCR), detects polymorphism
- UniSTS:143803

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: killer cell lectin-like receptor subfamily B member 1A

Names: CD161 antigen-like family member A; NKR-P1 2; lymphocyte antigen 55 complex, locus A; lymphocyte antigen 55A; natural killer cell receptor protein NKR-P1A; natural killer cell receptor-P1; natural killer cell surface protein P1-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159902.1 → NP_001153374.1 killer cell lectin-like receptor subfamily B member 1A isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC132352, BC120707, BC145045, M77676, M77753

Consensus CDS

CCDS51918.1

UniProtKB/TrEMBL

B7ZN67, E9Q0W1

Related

ENSMUSP00000132390.3, ENSMUST00000171306.5

Conserved Domains (1) summary

cd03593
Location:67 → 185

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_010737.3 → NP_034867.3 killer cell lectin-like receptor subfamily B member 1A isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC132352, BC120707, M77676, M77753

Consensus CDS

CCDS20574.2

UniProtKB/TrEMBL

A0A1U9W180, G5E882

Related

ENSMUSP00000032512.9, ENSMUST00000032512.15

Conserved Domains (2) summary

cd03593
Location:100 → 218

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

PHA03097
Location:47 → 221

PHA03097; C-type lectin-like protein; Provisional