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Stard6 StAR related lipid transfer domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 170461, updated on 5-Mar-2024

Summary

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Official Symbol
Stard6provided by MGI
Official Full Name
StAR related lipid transfer domain containing 6provided by MGI
Primary source
MGI:MGI:2156774
See related
Ensembl:ENSMUSG00000079608 AllianceGenome:MGI:2156774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700011K09Rik; 4833424I06Rik; 4933429L05Rik
Summary
Predicted to enable cholesterol binding activity. Predicted to act upstream of or within lipid transport. Orthologous to human STARD6 (StAR related lipid transfer domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 26.3) and frontal lobe adult (RPKM 0.4) See more
Orthologs
human all
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Genomic context

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Location:
18 E2; 18 44.44 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (70605525..70638325)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (70472454..70505254)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44960 Neighboring gene dynactin associated protein like 1 Neighboring gene STARR-seq mESC enhancer starr_44961 Neighboring gene STARR-seq mESC enhancer starr_44962 Neighboring gene predicted gene, 31620 Neighboring gene RIKEN cDNA 4930503L19 gene Neighboring gene STARR-positive B cell enhancer ABC_E11002 Neighboring gene STARR-positive B cell enhancer ABC_E1519 Neighboring gene STARR-positive B cell enhancer ABC_E8725 Neighboring gene microRNA 6357 Neighboring gene polymerase (DNA directed), iota Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:70722848-70723181 Neighboring gene STARR-seq mESC enhancer starr_44965 Neighboring gene predicted gene, 31671 Neighboring gene methyl-CpG binding domain protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. StAR-like activity and molten globule behavior of StARD6, a male germ-line protein. Bose HS, et al. Biochemistry, 2008 Feb 26. PMID 18211099
  2. Analysis of the Par2 modifier of pulmonary adenoma formation in mice. Wang M, et al. Exp Lung Res, 2005 Mar. PMID 15828125
  3. The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. Soccio RE, et al. Proc Natl Acad Sci U S A, 2002 May 14. PMID 12011452, Free PMC Article
  4. Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain. Romanowski MJ, et al. Proc Natl Acad Sci U S A, 2002 May 14. PMID 12011453, Free PMC Article
  5. Gene mapping of sperm quality parameters in recombinant inbred strains of mice. Golas A, et al. Int J Dev Biol, 2008. PMID 18311719

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC107178

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
stAR-related lipid transfer protein 6
Names
START domain containing protein 6
StAR-related lipid transfer (START) domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289648.1 → NP_001276577.1  stAR-related lipid transfer protein 6

    See identical proteins and their annotated locations for NP_001276577.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK014759, BE691268, BY085273, JF440953
    Consensus CDS
    CCDS37854.1
    UniProtKB/Swiss-Prot
    P59096
    UniProtKB/TrEMBL
    Q9CPT8, R4HJA5
    Related
    ENSMUSP00000130991.3, ENSMUST00000168249.9
    Conserved Domains (1) summary
    cl14643
    Location:1 → 204
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  2. NM_001289649.1 → NP_001276578.1  stAR-related lipid transfer protein 6

    See identical proteins and their annotated locations for NP_001276578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK014759, AK016984, BE691268, JF440953
    Consensus CDS
    CCDS37854.1
    UniProtKB/Swiss-Prot
    P59096
    UniProtKB/TrEMBL
    Q9CPT8, R4HJA5
    Related
    ENSMUSP00000126055.2, ENSMUST00000164223.8
    Conserved Domains (1) summary
    cl14643
    Location:1 → 204
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  3. NM_001289650.1 → NP_001276579.1  stAR-related lipid transfer protein 6

    See identical proteins and their annotated locations for NP_001276579.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK005873, AK014759, BE691268
    Consensus CDS
    CCDS37854.1
    UniProtKB/Swiss-Prot
    P59096
    UniProtKB/TrEMBL
    Q9CPT8, R4HJA5
    Related
    ENSMUSP00000134511.2, ENSMUST00000174118.8
    Conserved Domains (1) summary
    cl14643
    Location:1 → 204
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  4. NM_029019.4 → NP_083295.1  stAR-related lipid transfer protein 6

    See identical proteins and their annotated locations for NP_083295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC162297, AK014759, BE691268
    Consensus CDS
    CCDS37854.1
    UniProtKB/Swiss-Prot
    P59096
    UniProtKB/TrEMBL
    Q9CPT8, R4HJA5
    Related
    ENSMUSP00000110609.3, ENSMUST00000114959.9
    Conserved Domains (1) summary
    cl14643
    Location:1 → 204
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    70605525..70638325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161003.1 → XP_036016896.1  stAR-related lipid transfer protein 6 isoform X1

    UniProtKB/TrEMBL
    R4HJA5
    Conserved Domains (1) summary
    cl14643
    Location:1 → 202
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  2. XM_011246853.1 → XP_011245155.1  stAR-related lipid transfer protein 6 isoform X2

    Conserved Domains (1) summary
    cl14643
    Location:3 → 117
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59096.1 GenPept UniProtKB/Swiss-Prot:P59096

Gene LinkOut

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