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Stard4 StAR related lipid transfer domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 170459, updated on 5-Mar-2024

Summary

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Official Symbol
Stard4provided by MGI
Official Full Name
StAR related lipid transfer domain containing 4provided by MGI
Primary source
MGI:MGI:2156764
See related
Ensembl:ENSMUSG00000024378 AllianceGenome:MGI:2156764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4632419C16Rik; 9030213J02Rik
Summary
Predicted to enable cholesterol binding activity and cholesterol transfer activity. Involved in cholesterol esterification. Located in cytosol and endoplasmic reticulum. Is expressed in gut and urinary system. Orthologous to human STARD4 (StAR related lipid transfer domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 12.6), large intestine adult (RPKM 11.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stard4 in Genome Data Viewer
Location:
18 B1; 18 18.18 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (33332191..33346937, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (33199138..33213862, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310026I22 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:33100529-33100712 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:33105060-33105243 Neighboring gene STARR-seq mESC enhancer starr_44161 Neighboring gene calcium/calmodulin-dependent protein kinase IV Neighboring gene STARR-seq mESC enhancer starr_44162 Neighboring gene STARR-seq mESC enhancer starr_44163 Neighboring gene STARR-seq mESC enhancer starr_44164 Neighboring gene STARR-seq mESC enhancer starr_44165 Neighboring gene predicted gene, 54015 Neighboring gene STARR-positive B cell enhancer ABC_E775 Neighboring gene predicted gene, 41683 Neighboring gene VISTA enhancer mm76 Neighboring gene predicted gene, 46640 Neighboring gene O-sialoglycoprotein endopeptidase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. STARD4 Membrane Interactions and Sterol Binding. Iaea DB, et al. Biochemistry, 2015 Aug 4. PMID 26168008, Free PMC Article
  2. Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolism. Riegelhaupt JJ, et al. J Lipid Res, 2010 May. PMID 19965609, Free PMC Article
  3. Subcellular localization and regulation of StarD4 protein in macrophages and fibroblasts. Rodriguez-Agudo D, et al. Biochim Biophys Acta, 2011 Oct. PMID 21767660, Free PMC Article
  4. Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress. Soccio RE, et al. J Biol Chem, 2005 May 13. PMID 15760897
  5. Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation. Rodriguez-Agudo D, et al. J Lipid Res, 2008 Jul. PMID 18403318, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a model of STARD4 membrane interaction and sterol binding and release that requires dynamic movement of both the Omega1 loop and membrane insertion of the C-terminal alpha-helix.
    Title: STARD4 Membrane Interactions and Sterol Binding.
  2. StARD4's role can largely be compensated for by other intracellular cholesterol transporters.
    Title: Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolism.
  3. StarD4 plays an important role as a directional cholesterol transporter in the maintenance of cellular cholesterol homeostasis
    Title: Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation.
  4. StarD4 is regulated by sterols via SREBP-2, and StarD5 is activated by ER stress cholesterol metabolism; they serve different functions
    Title: Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables cholesterol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cholesterol import IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol import ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol transport involved in cholesterol storage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol transport involved in cholesterol storage ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
stAR-related lipid transfer protein 4
Names
START domain-containing protein 4
StAR-related lipid transfer (START) domain containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347624.1 → NP_001334553.1  stAR-related lipid transfer protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and contains an alternate exon, resulting in a frameshift compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC114919
    Consensus CDS
    CCDS84369.1
    UniProtKB/TrEMBL
    D3YW30
    Related
    ENSMUSP00000114109.2, ENSMUST00000119991.8

  2. NM_133774.5 → NP_598535.1  stAR-related lipid transfer protein 4 isoform 1

    See identical proteins and their annotated locations for NP_598535.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC114919, AK085331, BB850053
    Consensus CDS
    CCDS29123.1
    UniProtKB/Swiss-Prot
    Q99JV5
    UniProtKB/TrEMBL
    Q80SX0
    Related
    ENSMUSP00000025236.3, ENSMUST00000025236.9
    Conserved Domains (1) summary
    cd08902
    Location:21 → 222
    START_STARD4-like; Lipid-binding START domain of mammalian STARD4 and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    33332191..33346937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161001.1 → XP_036016894.1  stAR-related lipid transfer protein 4 isoform X1

    UniProtKB/TrEMBL
    D3YW24
    Related
    ENSMUSP00000114131.2, ENSMUST00000118990.2
    Conserved Domains (1) summary
    cl14643
    Location:21 → 110
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_180986.1: Suppressed sequence

    Description
    NM_180986.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JV5.1 GenPept UniProtKB/Swiss-Prot:Q99JV5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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